ENSG00000122692

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397149 ENSG00000122692 HEK293_OSMI2_2hA HEK293_TMG_2hB SMU1 protein_coding protein_coding 60.57019 38.43516 87.55558 4.438548 2.132071 1.187562 5.458861 4.930783 7.016114 0.6434858 0.2155309 0.5079873 0.1046042 0.1284000 0.08013333 -0.04826667 2.637005e-04 1.192803e-10 FALSE TRUE
MSTRG.32519.3 ENSG00000122692 HEK293_OSMI2_2hA HEK293_TMG_2hB SMU1 protein_coding   60.57019 38.43516 87.55558 4.438548 2.132071 1.187562 20.097659 19.180551 24.951855 2.6676272 1.0362843 0.3793290 0.3576583 0.4974333 0.28486667 -0.21256667 1.192803e-10 1.192803e-10 FALSE TRUE
MSTRG.32519.4 ENSG00000122692 HEK293_OSMI2_2hA HEK293_TMG_2hB SMU1 protein_coding   60.57019 38.43516 87.55558 4.438548 2.132071 1.187562 9.967530 2.084668 16.694905 1.0432985 1.8607961 2.9954784 0.1415333 0.0501000 0.19073333 0.14063333 3.612979e-01 1.192803e-10 FALSE TRUE
MSTRG.32519.6 ENSG00000122692 HEK293_OSMI2_2hA HEK293_TMG_2hB SMU1 protein_coding   60.57019 38.43516 87.55558 4.438548 2.132071 1.187562 24.946506 12.239163 38.726114 0.5911766 2.5517587 1.6609961 0.3943125 0.3241333 0.44233333 0.11820000 7.787979e-02 1.192803e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122692 E001 618.7753275 0.0004704975 1.116475e-14 3.646143e-13 9 33041765 33045953 4189 - 2.731 2.863 0.441
ENSG00000122692 E002 1235.0149313 0.0005300412 1.772122e-53 1.311913e-50 9 33045954 33047391 1438 - 2.993 3.197 0.676
ENSG00000122692 E003 572.0953435 0.0001209462 1.621159e-02 4.319115e-02 9 33048106 33048258 153 - 2.741 2.781 0.134
ENSG00000122692 E004 581.3873201 0.0001028339 2.888602e-01 4.295019e-01 9 33053123 33053290 168 - 2.756 2.776 0.065
ENSG00000122692 E005 467.1167750 0.0003445358 8.730338e-01 9.223997e-01 9 33056113 33056239 127 - 2.667 2.674 0.021
ENSG00000122692 E006 495.4979946 0.0001614781 3.606368e-03 1.202844e-02 9 33056837 33056964 128 - 2.713 2.668 -0.150
ENSG00000122692 E007 447.1735593 0.0001716020 6.875386e-06 4.743340e-05 9 33057598 33057714 117 - 2.680 2.603 -0.254
ENSG00000122692 E008 331.3771951 0.0014273023 2.144689e-03 7.674385e-03 9 33060465 33060541 77 - 2.552 2.471 -0.271
ENSG00000122692 E009 246.1182075 0.0021197958 4.807236e-02 1.057558e-01 9 33060542 33060584 43 - 2.417 2.356 -0.204
ENSG00000122692 E010 435.4421519 0.0001964106 2.874375e-05 1.717689e-04 9 33062049 33062177 129 - 2.668 2.597 -0.237
ENSG00000122692 E011 392.7961580 0.0001308126 3.025286e-08 3.402382e-07 9 33068824 33068934 111 - 2.633 2.533 -0.330
ENSG00000122692 E012 421.6046668 0.0001795079 1.575414e-13 4.355771e-12 9 33071740 33071892 153 - 2.674 2.541 -0.443
ENSG00000122692 E013 547.9305298 0.0023101577 2.130256e-09 2.968522e-08 9 33073596 33073806 211 - 2.798 2.630 -0.560
ENSG00000122692 E014 312.5865554 0.0073102347 8.075198e-05 4.314827e-04 9 33076583 33076729 147 - 2.562 2.373 -0.629
ENSG00000122692 E015 1.1040209 0.0117564585 6.192309e-01 7.367004e-01 9 33076730 33076798 69 - 0.354 0.265 -0.579
ENSG00000122692 E016 0.1451727 0.0436861792 8.142261e-01   9 33081315 33081369 55 - 0.097 0.001 -7.691