ENSG00000122642

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000242209 ENSG00000122642 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP9 protein_coding protein_coding 18.0689 18.09782 19.75031 1.885206 0.8268826 0.1259929 9.2624414 7.1703382 10.132381 1.0501394 0.2902654 0.49827261 0.51580417 0.39850000 0.51370000 0.11520000 2.158138e-01 3.165509e-12 FALSE TRUE
ENST00000418354 ENSG00000122642 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP9 protein_coding protein_coding 18.0689 18.09782 19.75031 1.885206 0.8268826 0.1259929 0.4282162 0.0000000 1.704285 0.0000000 0.3904860 7.42146303 0.02483750 0.00000000 0.08756667 0.08756667 1.703905e-11 3.165509e-12 FALSE FALSE
ENST00000468510 ENSG00000122642 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP9 protein_coding retained_intron 18.0689 18.09782 19.75031 1.885206 0.8268826 0.1259929 1.5613290 0.2218042 2.667079 0.2218042 1.0674700 3.52968094 0.08471667 0.01090000 0.13120000 0.12030000 4.685821e-02 3.165509e-12 FALSE TRUE
ENST00000472007 ENSG00000122642 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP9 protein_coding processed_transcript 18.0689 18.09782 19.75031 1.885206 0.8268826 0.1259929 2.7731916 2.4825923 2.414923 0.1964141 0.3381526 -0.03970812 0.15224167 0.13800000 0.12136667 -0.01663333 7.297888e-01 3.165509e-12 FALSE FALSE
ENST00000475220 ENSG00000122642 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP9 protein_coding processed_transcript 18.0689 18.09782 19.75031 1.885206 0.8268826 0.1259929 0.7967427 1.2076784 0.000000 0.6205196 0.0000000 -6.92798929 0.04027083 0.06063333 0.00000000 -0.06063333 1.111367e-01 3.165509e-12 FALSE TRUE
ENST00000490776 ENSG00000122642 HEK293_OSMI2_2hA HEK293_TMG_2hB FKBP9 protein_coding protein_coding 18.0689 18.09782 19.75031 1.885206 0.8268826 0.1259929 1.0681321 4.2378216 0.000000 1.3338657 0.0000000 -8.73057935 0.06160000 0.23590000 0.00000000 -0.23590000 3.165509e-12 3.165509e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122642 E001 2.1222916 0.7184002309 3.422920e-01 4.862951e-01 7 32957404 32957424 21 + 0.633 0.312 -1.652
ENSG00000122642 E002 5.8914504 0.2857224797 9.294860e-01 9.596042e-01 7 32957425 32957437 13 + 0.899 0.773 -0.492
ENSG00000122642 E003 6.0397436 0.2612923289 9.827140e-01 9.932628e-01 7 32957438 32957439 2 + 0.899 0.793 -0.412
ENSG00000122642 E004 6.0397436 0.2612923289 9.827140e-01 9.932628e-01 7 32957440 32957440 1 + 0.899 0.793 -0.412
ENSG00000122642 E005 58.9589631 0.0202921915 3.500237e-02 8.165768e-02 7 32957441 32957794 354 + 1.861 1.689 -0.579
ENSG00000122642 E006 1.5584654 0.0097058714 4.673639e-01 6.068670e-01 7 32963544 32963702 159 + 0.477 0.356 -0.653
ENSG00000122642 E007 0.3299976 0.0274424043 2.171613e-01   7 32974595 32974616 22 + 0.000 0.214 12.058
ENSG00000122642 E008 78.3727538 0.0003886066 1.486012e-02 4.017372e-02 7 32974617 32974762 146 + 1.947 1.859 -0.298
ENSG00000122642 E009 0.2944980 0.4099020037 2.850156e-01   7 32974763 32975181 419 + 0.222 0.000 -11.664
ENSG00000122642 E010 66.2012046 0.0020601567 1.413374e-03 5.351336e-03 7 32975182 32975240 59 + 1.903 1.757 -0.489
ENSG00000122642 E011 106.4801464 0.0041693655 1.085875e-02 3.082762e-02 7 32975241 32975371 131 + 2.090 1.980 -0.371
ENSG00000122642 E012 75.4149807 0.0103716007 2.561162e-01 3.930754e-01 7 32976354 32976407 54 + 1.922 1.848 -0.248
ENSG00000122642 E013 84.7725741 0.0013703068 2.106172e-02 5.372398e-02 7 32976408 32976499 92 + 1.980 1.891 -0.299
ENSG00000122642 E014 0.1482932 0.0408610231 5.116692e-01   7 32976500 32976504 5 + 0.000 0.120 10.902
ENSG00000122642 E015 0.4396707 0.0330454389 7.814722e-02 1.564886e-01 7 32979474 32979583 110 + 0.301 0.000 -13.503
ENSG00000122642 E016 85.9730557 0.0033593919 9.659204e-02 1.852489e-01 7 32980364 32980437 74 + 1.977 1.904 -0.247
ENSG00000122642 E017 135.4111522 0.0003292810 1.076622e-01 2.020871e-01 7 32980438 32980553 116 + 2.156 2.114 -0.140
ENSG00000122642 E018 122.9820958 0.0028660141 5.708875e-01 6.973064e-01 7 32988507 32988585 79 + 2.102 2.087 -0.052
ENSG00000122642 E019 107.1851106 0.0003319612 3.308939e-01 4.744654e-01 7 32988586 32988652 67 + 2.050 2.025 -0.085
ENSG00000122642 E020 12.4406462 0.0014306000 9.518289e-01 9.738350e-01 7 32988653 32989026 374 + 1.125 1.137 0.045
ENSG00000122642 E021 7.5846794 0.0047417562 9.309702e-01 9.605507e-01 7 32992722 32993074 353 + 0.920 0.936 0.060
ENSG00000122642 E022 3.3043928 0.0070904723 1.517942e-02 4.089501e-02 7 32994991 32995105 115 + 0.368 0.761 1.841
ENSG00000122642 E023 130.8030143 0.0016492212 8.140857e-02 1.617626e-01 7 32996163 32996349 187 + 2.151 2.098 -0.177
ENSG00000122642 E024 0.0000000       7 32998539 32998598 60 +      
ENSG00000122642 E025 111.1669928 0.0063816157 1.887377e-01 3.121549e-01 7 33000115 33000260 146 + 2.082 2.023 -0.196
ENSG00000122642 E026 0.1451727 0.0429129057 4.701525e-01   7 33000261 33000261 1 + 0.125 0.000 -11.805
ENSG00000122642 E027 82.4560275 0.0003837314 4.865601e-01 6.242668e-01 7 33002676 33002761 86 + 1.904 1.939 0.114
ENSG00000122642 E028 78.8409192 0.0003668841 1.575180e-01 2.718110e-01 7 33002762 33002839 78 + 1.871 1.934 0.212
ENSG00000122642 E029 2.9967514 0.0055071448 8.327430e-02 1.646909e-01 7 33002840 33002917 78 + 0.727 0.464 -1.182
ENSG00000122642 E030 0.7406253 0.0153789198 1.457205e-02 3.952682e-02 7 33002918 33002928 11 + 0.426 0.000 -14.543
ENSG00000122642 E031 512.7862762 0.0011920873 8.007481e-21 5.656201e-19 7 33005175 33006930 1756 + 2.602 2.782 0.601