ENSG00000122591

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409763 ENSG00000122591 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126A protein_coding protein_coding 12.96358 3.987252 20.67172 0.5070593 0.3911969 2.371276 1.1116456 1.61345029 0.8244589 0.50337351 0.6563704 -0.9601503 0.18575833 0.384933333 0.03953333 -0.3454000 5.096074e-02 1.930421e-13 FALSE TRUE
ENST00000409923 ENSG00000122591 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126A protein_coding protein_coding 12.96358 3.987252 20.67172 0.5070593 0.3911969 2.371276 4.2554667 0.48592177 6.9840507 0.32526513 0.6023501 3.8179438 0.26500833 0.147066667 0.33916667 0.1921000 4.300503e-01 1.930421e-13 FALSE TRUE
ENST00000440481 ENSG00000122591 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126A protein_coding protein_coding 12.96358 3.987252 20.67172 0.5070593 0.3911969 2.371276 1.8100688 1.29326728 3.4425290 0.17815061 0.3152468 1.4055206 0.17590417 0.324633333 0.16676667 -0.1578667 2.776604e-03 1.930421e-13 FALSE TRUE
ENST00000681237 ENSG00000122591 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126A protein_coding nonsense_mediated_decay 12.96358 3.987252 20.67172 0.5070593 0.3911969 2.371276 1.6617175 0.01034988 2.2780235 0.01034988 1.1787280 6.8129376 0.08194583 0.002633333 0.10820000 0.1055667 4.403785e-01 1.930421e-13 FALSE TRUE
ENST00000681766 ENSG00000122591 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126A protein_coding protein_coding 12.96358 3.987252 20.67172 0.5070593 0.3911969 2.371276 0.6174889 0.12811990 0.7175555 0.12811990 0.7175555 2.3971360 0.05721250 0.032700000 0.03400000 0.0013000 8.541015e-01 1.930421e-13 FALSE TRUE
MSTRG.29563.7 ENSG00000122591 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM126A protein_coding   12.96358 3.987252 20.67172 0.5070593 0.3911969 2.371276 2.3206397 0.00000000 4.5754731 0.00000000 0.5263601 8.8409268 0.12297917 0.000000000 0.22246667 0.2224667 1.930421e-13 1.930421e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122591 E001 0.5149111 0.0202068702 3.901428e-02 8.922402e-02 7 22889371 22889693 323 - 0.052 0.426 3.710
ENSG00000122591 E002 0.4449813 0.0214581917 3.821898e-01 5.264228e-01 7 22890935 22891149 215 - 0.098 0.263 1.708
ENSG00000122591 E003 0.1482932 0.0411878876 6.241719e-02   7 22920232 22920325 94 - 0.000 0.263 11.932
ENSG00000122591 E004 12.0111409 0.0961416598 2.541120e-03 8.886158e-03 7 22934211 22940971 6761 - 0.846 1.393 1.981
ENSG00000122591 E005 0.0000000       7 22940972 22941083 112 -      
ENSG00000122591 E006 0.0000000       7 22941084 22941165 82 -      
ENSG00000122591 E007 1.4079796 0.0181366533 1.611737e-04 7.971876e-04 7 22941166 22941268 103 - 0.098 0.778 4.296
ENSG00000122591 E008 14.2947071 0.0317336531 8.424598e-14 2.421139e-12 7 22941269 22941339 71 - 0.705 1.655 3.439
ENSG00000122591 E009 20.8678569 0.0457948246 7.293239e-09 9.214900e-08 7 22941340 22941367 28 - 0.955 1.739 2.747
ENSG00000122591 E010 69.0890213 0.0427801219 8.247254e-11 1.476207e-09 7 22941368 22941823 456 - 1.462 2.237 2.618
ENSG00000122591 E011 398.4865446 0.0002424047 1.698879e-12 4.008064e-11 7 22941824 22944275 2452 - 2.481 2.349 -0.440
ENSG00000122591 E012 74.3068100 0.0043206746 1.998303e-04 9.630194e-04 7 22944276 22944508 233 - 1.767 1.546 -0.749
ENSG00000122591 E013 47.9157032 0.0006908002 5.145986e-02 1.117482e-01 7 22944509 22944650 142 - 1.567 1.467 -0.342
ENSG00000122591 E014 251.8509414 0.0043777690 2.416606e-02 6.014988e-02 7 22944651 22945571 921 - 2.272 2.218 -0.180
ENSG00000122591 E015 168.0232531 0.0003539657 1.722044e-01 2.910743e-01 7 22945572 22945982 411 - 2.074 2.166 0.309
ENSG00000122591 E016 115.1924371 0.0013473298 3.845321e-01 5.286804e-01 7 22945983 22946163 181 - 1.913 1.997 0.280
ENSG00000122591 E017 34.1670498 0.0006461933 7.457597e-01 8.337136e-01 7 22946952 22947032 81 - 1.399 1.467 0.235
ENSG00000122591 E018 60.8913442 0.0120082705 6.618305e-01 7.702200e-01 7 22947033 22947247 215 - 1.643 1.715 0.245
ENSG00000122591 E019 96.1604342 0.0003356989 1.095656e-03 4.289496e-03 7 22960256 22960415 160 - 1.869 1.741 -0.433
ENSG00000122591 E020 0.0000000       7 22960926 22961048 123 -      
ENSG00000122591 E021 46.6616657 0.0004883611 7.107666e-03 2.150430e-02 7 22961235 22961268 34 - 1.564 1.400 -0.561
ENSG00000122591 E022 46.5881935 0.0056980703 1.615335e-01 2.771020e-01 7 22961269 22961322 54 - 1.552 1.479 -0.248
ENSG00000122591 E023 63.4946895 0.0004518794 2.634381e-02 6.463621e-02 7 22964415 22964531 117 - 1.684 1.585 -0.337
ENSG00000122591 E024 59.2729459 0.0004684999 9.563824e-04 3.809503e-03 7 22976210 22976305 96 - 1.666 1.479 -0.636
ENSG00000122591 E025 0.8878743 0.0131256693 3.871267e-01 5.312760e-01 7 22976306 22976692 387 - 0.246 0.000 -12.102
ENSG00000122591 E026 55.8488133 0.0003998811 8.398047e-02 1.657777e-01 7 22976693 22976768 76 - 1.628 1.556 -0.246
ENSG00000122591 E027 45.3712901 0.0004710845 5.355314e-02 1.154707e-01 7 22976769 22976808 40 - 1.544 1.442 -0.351
ENSG00000122591 E028 0.0000000       7 22976809 22976858 50 -      
ENSG00000122591 E029 61.1549575 0.0005405951 3.720152e-04 1.666087e-03 7 22977341 22977421 81 - 1.682 1.479 -0.692
ENSG00000122591 E030 2.7784110 0.0059880977 2.478088e-04 1.166086e-03 7 22978164 22978268 105 - 0.305 0.929 2.879
ENSG00000122591 E031 70.4400863 0.0035724424 7.228703e-01 8.168783e-01 7 22978269 22978404 136 - 1.707 1.772 0.220
ENSG00000122591 E032 47.4205300 0.0006776511 1.553167e-01 2.688180e-01 7 22978405 22978448 44 - 1.526 1.662 0.465
ENSG00000122591 E033 0.0000000       7 22980297 22980320 24 -      
ENSG00000122591 E034 1.2274368 0.0235597022 8.943439e-01 9.364748e-01 7 22980321 22981663 1343 - 0.277 0.263 -0.098
ENSG00000122591 E035 2.8453272 0.0052267274 2.014866e-01 3.280304e-01 7 22981664 22983943 2280 - 0.517 0.263 -1.460
ENSG00000122591 E036 36.8114785 0.0007107421 5.774718e-01 7.027224e-01 7 22983944 22983948 5 - 1.429 1.514 0.292
ENSG00000122591 E037 67.1478235 0.0008733453 1.424515e-01 2.513741e-01 7 22983949 22984045 97 - 1.676 1.802 0.426
ENSG00000122591 E038 1.6672213 0.0345836235 6.095777e-01 7.290573e-01 7 22985548 22985735 188 - 0.357 0.263 -0.612
ENSG00000122591 E039 63.2395231 0.0004221563 4.305106e-01 5.731479e-01 7 22991061 22991139 79 - 1.658 1.748 0.303
ENSG00000122591 E040 56.4108704 0.0004440042 2.251813e-01 3.566381e-01 7 23013925 23014130 206 - 1.604 1.721 0.397