ENSG00000122545

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350320 ENSG00000122545 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN7 protein_coding protein_coding 58.7672 14.10459 110.1919 2.928754 2.039514 2.96489 15.8865646 4.2301114 28.095821 0.5958423 1.4184431 2.728695 0.30498333 0.31100000 0.2548000 -0.05620000 0.497005145 0.001036586 FALSE TRUE
ENST00000399035 ENSG00000122545 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN7 protein_coding protein_coding 58.7672 14.10459 110.1919 2.928754 2.039514 2.96489 0.1940892 0.6483122 0.000000 0.6483122 0.0000000 -6.040700 0.01780833 0.06656667 0.0000000 -0.06656667 0.525024465 0.001036586 FALSE TRUE
ENST00000485569 ENSG00000122545 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN7 protein_coding protein_coding 58.7672 14.10459 110.1919 2.928754 2.039514 2.96489 17.3187722 4.7501740 36.680762 2.3585054 2.3150184 2.946331 0.28977500 0.29786667 0.3331000 0.03523333 0.851696593 0.001036586 FALSE FALSE
ENST00000634600 ENSG00000122545 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN7 protein_coding protein_coding 58.7672 14.10459 110.1919 2.928754 2.039514 2.96489 19.3346086 1.8081729 35.635250 0.9198942 2.0846179 4.293149 0.25111667 0.11860000 0.3230667 0.20446667 0.452925018 0.001036586 FALSE FALSE
MSTRG.29726.4 ENSG00000122545 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN7 protein_coding   58.7672 14.10459 110.1919 2.928754 2.039514 2.96489 3.2240391 1.9665865 4.766615 0.2846708 0.2682885 1.272978 0.07820000 0.15156667 0.0433000 -0.10826667 0.001036586 0.001036586 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122545 E001 0.0000000       7 35800932 35801038 107 +      
ENSG00000122545 E002 0.1515154 0.0422540451 1.000000e+00   7 35801039 35801056 18 + 0.053 0.000 -7.151
ENSG00000122545 E003 2.2313244 0.0454577440 9.137603e-01 9.494016e-01 7 35801057 35801185 129 + 0.407 0.424 0.092
ENSG00000122545 E004 10.1541294 0.0209979648 5.534764e-01 6.826106e-01 7 35801186 35801215 30 + 0.895 1.037 0.531
ENSG00000122545 E005 9.6995831 0.0143278248 4.431775e-01 5.847410e-01 7 35801216 35801217 2 + 0.872 1.037 0.614
ENSG00000122545 E006 10.0285365 0.0150998259 3.366781e-01 4.805525e-01 7 35801218 35801218 1 + 0.880 1.068 0.702
ENSG00000122545 E007 44.5736809 0.0005575645 2.562595e-02 6.317682e-02 7 35801219 35801231 13 + 1.542 1.436 -0.364
ENSG00000122545 E008 119.5347274 0.0006325141 6.998358e-03 2.121886e-02 7 35801232 35801270 39 + 1.956 1.893 -0.210
ENSG00000122545 E009 0.7447779 0.1096087506 4.806982e-01 6.189255e-01 7 35831353 35831424 72 + 0.216 0.000 -9.455
ENSG00000122545 E010 14.1042633 0.0012585402 9.777322e-02 1.871070e-01 7 35831425 35831491 67 + 1.078 0.924 -0.570
ENSG00000122545 E011 93.8064769 0.0040839068 3.555790e-03 1.188507e-02 7 35831492 35831496 5 + 1.859 1.743 -0.393
ENSG00000122545 E012 0.8878743 0.0131377767 3.465371e-01 4.906608e-01 7 35831497 35832034 538 + 0.249 0.000 -9.717
ENSG00000122545 E013 0.0000000       7 35832669 35832674 6 +      
ENSG00000122545 E014 124.9096826 0.0002631745 1.561987e-03 5.836218e-03 7 35832798 35832803 6 + 1.977 1.898 -0.266
ENSG00000122545 E015 245.4072863 0.0023584901 1.290665e-03 4.944845e-03 7 35832804 35832893 90 + 2.266 2.203 -0.211
ENSG00000122545 E016 153.6225840 0.0010578155 5.761338e-03 1.798461e-02 7 35832894 35832900 7 + 2.063 2.009 -0.182
ENSG00000122545 E017 2.3551902 0.0140344281 2.742296e-01 4.133602e-01 7 35838564 35838657 94 + 0.384 0.632 1.211
ENSG00000122545 E018 0.0000000       7 35846760 35846813 54 +      
ENSG00000122545 E019 0.0000000       7 35846814 35846844 31 +      
ENSG00000122545 E020 0.0000000       7 35846845 35846911 67 +      
ENSG00000122545 E021 0.0000000       7 35846912 35847047 136 +      
ENSG00000122545 E022 0.0000000       7 35847915 35848004 90 +      
ENSG00000122545 E023 325.0731314 0.0001918960 3.588084e-07 3.266938e-06 7 35863552 35863658 107 + 2.390 2.311 -0.263
ENSG00000122545 E024 294.0443429 0.0002322300 1.674405e-03 6.200856e-03 7 35872666 35872766 101 + 2.339 2.313 -0.089
ENSG00000122545 E025 1.6232115 0.0155546408 6.512498e-02 1.352436e-01 7 35872767 35873640 874 + 0.249 0.632 2.085
ENSG00000122545 E026 335.8572238 0.0003023799 4.986569e-03 1.589238e-02 7 35873641 35873775 135 + 2.394 2.382 -0.040
ENSG00000122545 E027 10.7826304 0.0015635793 7.537711e-01 8.395856e-01 7 35873776 35879476 5701 + 0.948 0.964 0.060
ENSG00000122545 E028 2.6176359 0.0249956930 3.336381e-01 4.773742e-01 7 35879596 35879719 124 + 0.406 0.634 1.093
ENSG00000122545 E029 298.6505110 0.0002113778 1.280752e-02 3.546215e-02 7 35879823 35879940 118 + 2.341 2.335 -0.021
ENSG00000122545 E030 282.7522778 0.0011626520 1.212944e-02 3.384571e-02 7 35882484 35882576 93 + 2.320 2.301 -0.062
ENSG00000122545 E031 288.5446951 0.0009615697 1.614095e-01 2.769269e-01 7 35883891 35883987 97 + 2.322 2.342 0.067
ENSG00000122545 E032 247.4409879 0.0002223445 4.444397e-01 5.860131e-01 7 35885828 35885879 52 + 2.252 2.293 0.136
ENSG00000122545 E033 1.6651450 0.2177745310 6.670155e-01 7.743610e-01 7 35890518 35890667 150 + 0.360 0.261 -0.650
ENSG00000122545 E034 286.6760418 0.0002634294 1.385398e-02 3.789428e-02 7 35890668 35890743 76 + 2.324 2.316 -0.025
ENSG00000122545 E035 251.5289667 0.0001808982 1.509265e-01 2.629299e-01 7 35890744 35890793 50 + 2.263 2.284 0.069
ENSG00000122545 E036 2.8839221 0.0051192010 5.368730e-01 6.685402e-01 7 35898215 35898247 33 + 0.504 0.422 -0.418
ENSG00000122545 E037 466.9157076 0.0005249823 6.513454e-01 7.622225e-01 7 35898248 35898383 136 + 2.525 2.579 0.180
ENSG00000122545 E038 54.3348893 0.0115874696 9.291269e-02 1.796834e-01 7 35898384 35903075 4692 + 1.623 1.540 -0.284
ENSG00000122545 E039 463.6652030 0.0004141558 9.903781e-01 9.981159e-01 7 35903076 35903215 140 + 2.521 2.585 0.214
ENSG00000122545 E040 1021.3624312 0.0246160452 4.461542e-04 1.952068e-03 7 35904254 35907110 2857 + 2.813 3.106 0.974