ENSG00000122515

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265346 ENSG00000122515 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ2 protein_coding protein_coding 32.99189 41.03649 23.68747 2.394329 0.3567407 -0.7925259 7.5314965 11.6942315 3.4985997 1.3558237 0.5119177 -1.7380630 0.21328750 0.288633333 0.148200000 -0.140433333 5.178474e-02 6.323172e-10 FALSE  
ENST00000309315 ENSG00000122515 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ2 protein_coding protein_coding 32.99189 41.03649 23.68747 2.394329 0.3567407 -0.7925259 3.2307804 1.7771845 4.3247082 1.7771845 0.2947946 1.2782463 0.09875417 0.045733333 0.183000000 0.137266667 9.690346e-02 6.323172e-10 FALSE  
ENST00000441627 ENSG00000122515 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ2 protein_coding protein_coding 32.99189 41.03649 23.68747 2.394329 0.3567407 -0.7925259 0.9851727 3.1082971 0.2103457 1.5890005 0.2103457 -3.8229178 0.03075833 0.073566667 0.008633333 -0.064933333 4.777583e-01 6.323172e-10 FALSE  
ENST00000463931 ENSG00000122515 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ2 protein_coding processed_transcript 32.99189 41.03649 23.68747 2.394329 0.3567407 -0.7925259 3.8849541 8.5406609 0.7004005 3.0159350 0.3009145 -3.5893314 0.10456667 0.208433333 0.029500000 -0.178933333 6.386323e-02 6.323172e-10 FALSE  
ENST00000478045 ENSG00000122515 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ2 protein_coding retained_intron 32.99189 41.03649 23.68747 2.394329 0.3567407 -0.7925259 2.5171921 1.4833016 2.4782786 0.1960696 0.2545870 0.7366424 0.08244167 0.035833333 0.104433333 0.068600000 3.033205e-07 6.323172e-10 FALSE  
ENST00000482322 ENSG00000122515 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ2 protein_coding retained_intron 32.99189 41.03649 23.68747 2.394329 0.3567407 -0.7925259 1.1226115 0.1814048 1.5814128 0.1044697 0.3249418 3.0556089 0.03902083 0.004466667 0.066533333 0.062066667 1.159745e-03 6.323172e-10 FALSE  
MSTRG.29816.10 ENSG00000122515 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ2 protein_coding   32.99189 41.03649 23.68747 2.394329 0.3567407 -0.7925259 2.3996871 4.1247405 2.5574331 1.4205515 0.1337981 -0.6874701 0.07142917 0.097333333 0.108166667 0.010833333 8.378127e-01 6.323172e-10 FALSE  
MSTRG.29816.7 ENSG00000122515 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMIZ2 protein_coding   32.99189 41.03649 23.68747 2.394329 0.3567407 -0.7925259 3.8595415 4.1588429 2.6420752 0.2524803 0.5489636 -0.6525253 0.12252083 0.101600000 0.111266667 0.009666667 9.518623e-01 6.323172e-10 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122515 E001 0.0000000       7 44748544 44748564 21 +      
ENSG00000122515 E002 0.6717251 0.0254545415 1.157308e-01 2.138572e-01 7 44748565 44748567 3 + 0.355 0.098 -2.328
ENSG00000122515 E003 1.1834270 0.0112249506 7.000518e-01 7.996266e-01 7 44748568 44748571 4 + 0.355 0.302 -0.330
ENSG00000122515 E004 2.7323260 0.0063045410 8.833673e-01 9.293898e-01 7 44748572 44748580 9 + 0.548 0.546 -0.008
ENSG00000122515 E005 6.4046106 0.1068759062 7.908905e-01 8.662752e-01 7 44748581 44748631 51 + 0.840 0.840 0.002
ENSG00000122515 E006 0.2903454 0.3054136171 1.331779e-01   7 44748847 44748854 8 + 0.265 0.000 -19.374
ENSG00000122515 E007 0.8836079 0.0136968632 9.182698e-04 3.678497e-03 7 44748855 44748861 7 + 0.548 0.000 -20.963
ENSG00000122515 E008 8.5698507 0.0084447211 1.897955e-09 2.669353e-08 7 44748862 44748932 71 + 1.281 0.604 -2.584
ENSG00000122515 E009 24.0551337 0.0007957804 8.470533e-06 5.721733e-05 7 44748933 44748961 29 + 1.535 1.252 -0.982
ENSG00000122515 E010 38.9168907 0.0081711304 2.185669e-03 7.797311e-03 7 44748962 44748991 30 + 1.683 1.501 -0.623
ENSG00000122515 E011 7.9879427 0.0021572771 1.563203e-01 2.702217e-01 7 44749815 44749980 166 + 1.012 0.877 -0.504
ENSG00000122515 E012 4.0774857 0.0046985994 5.545862e-01 6.835476e-01 7 44750972 44751091 120 + 0.717 0.655 -0.258
ENSG00000122515 E013 1.1501176 0.0124721994 5.823895e-02 1.236115e-01 7 44756179 44756187 9 + 0.492 0.177 -2.066
ENSG00000122515 E014 50.8263571 0.0191300324 4.958020e-02 1.084183e-01 7 44756188 44756204 17 + 1.763 1.640 -0.415
ENSG00000122515 E015 114.3534667 0.0136570483 1.143065e-02 3.218835e-02 7 44756205 44756299 95 + 2.114 1.988 -0.423
ENSG00000122515 E016 168.1142378 0.0055017840 4.471968e-03 1.446328e-02 7 44756425 44756539 115 + 2.259 2.168 -0.306
ENSG00000122515 E017 5.9203919 0.0055974514 4.858166e-13 1.253220e-11 7 44756540 44756946 407 + 1.209 0.244 -4.330
ENSG00000122515 E018 97.7361708 0.0075437311 1.163632e-01 2.147640e-01 7 44756947 44756974 28 + 2.002 1.950 -0.174
ENSG00000122515 E019 122.9023298 0.0083325302 1.849618e-01 3.074398e-01 7 44756975 44757042 68 + 2.090 2.054 -0.122
ENSG00000122515 E020 164.9862149 0.0044261600 4.572843e-02 1.015343e-01 7 44757043 44757149 107 + 2.223 2.174 -0.163
ENSG00000122515 E021 177.6118158 0.0034551629 9.709687e-02 1.860363e-01 7 44757378 44757561 184 + 2.240 2.211 -0.097
ENSG00000122515 E022 224.4287882 0.0002169328 9.078377e-02 1.763721e-01 7 44757848 44758108 261 + 2.327 2.316 -0.037
ENSG00000122515 E023 206.0293480 0.0049979868 1.149415e-01 2.127535e-01 7 44759281 44759460 180 + 2.304 2.276 -0.095
ENSG00000122515 E024 14.4758969 0.0012538069 9.020424e-07 7.562140e-06 7 44759734 44759950 217 + 1.383 0.980 -1.439
ENSG00000122515 E025 17.3345510 0.0010458228 6.155591e-13 1.563215e-11 7 44759951 44760150 200 + 1.519 0.957 -1.992
ENSG00000122515 E026 39.7758751 0.0095868716 1.157846e-02 3.253298e-02 7 44760151 44760228 78 + 1.671 1.523 -0.506
ENSG00000122515 E027 17.7525721 0.0193143600 2.141575e-06 1.654831e-05 7 44760229 44760424 196 + 1.484 1.030 -1.603
ENSG00000122515 E028 253.3152353 0.0034449150 4.710736e-02 1.040182e-01 7 44760425 44760593 169 + 2.398 2.364 -0.114
ENSG00000122515 E029 12.4229212 0.0014762837 1.599254e-01 2.750158e-01 7 44761422 44761448 27 + 1.161 1.054 -0.387
ENSG00000122515 E030 242.7255221 0.0003120216 6.872322e-02 1.412497e-01 7 44761449 44761593 145 + 2.365 2.351 -0.044
ENSG00000122515 E031 18.0504008 0.0148823680 2.190281e-04 1.045379e-03 7 44761594 44761694 101 + 1.447 1.116 -1.162
ENSG00000122515 E032 243.0007737 0.0002089066 1.052897e-01 1.985351e-01 7 44761695 44761807 113 + 2.362 2.354 -0.026
ENSG00000122515 E033 204.7611165 0.0002755544 6.539343e-01 7.642699e-01 7 44761808 44761905 98 + 2.269 2.289 0.065
ENSG00000122515 E034 197.0309866 0.0004555099 8.556037e-01 9.107239e-01 7 44762881 44762986 106 + 2.238 2.275 0.123
ENSG00000122515 E035 265.5695967 0.0016764284 6.245261e-01 7.408149e-01 7 44763256 44763413 158 + 2.381 2.401 0.066
ENSG00000122515 E036 0.3299976 0.0278125541 4.112052e-01   7 44763689 44763750 62 + 0.000 0.177 17.611
ENSG00000122515 E037 195.5233587 0.0041951699 7.371314e-01 8.273829e-01 7 44764419 44764486 68 + 2.249 2.271 0.073
ENSG00000122515 E038 193.0835263 0.0006271941 3.822446e-01 5.264763e-01 7 44764941 44765009 69 + 2.218 2.276 0.192
ENSG00000122515 E039 240.5607967 0.0002001283 2.366448e-07 2.236104e-06 7 44765335 44765579 245 + 2.237 2.399 0.543
ENSG00000122515 E040 5.0499313 0.0100175241 8.158087e-06 5.530596e-05 7 44765580 44765710 131 + 1.062 0.478 -2.391
ENSG00000122515 E041 3.2410002 0.0047983626 1.056082e-03 4.153621e-03 7 44765711 44765743 33 + 0.864 0.399 -2.068
ENSG00000122515 E042 10.7319461 0.0052246172 9.427908e-10 1.404379e-08 7 44765744 44765966 223 + 1.352 0.742 -2.248
ENSG00000122515 E043 7.7972215 0.0022044569 9.837610e-06 6.551732e-05 7 44765967 44766056 90 + 1.173 0.701 -1.790
ENSG00000122515 E044 7.4374283 0.1603933126 2.669224e-03 9.280002e-03 7 44766057 44766163 107 + 1.211 0.598 -2.361
ENSG00000122515 E045 215.3682129 0.0007977170 3.338616e-02 7.854881e-02 7 44766164 44766333 170 + 2.241 2.334 0.311
ENSG00000122515 E046 391.9025509 0.0033162726 2.498859e-03 8.759715e-03 7 44766421 44766663 243 + 2.470 2.606 0.454
ENSG00000122515 E047 1306.3327983 0.0061547214 5.278842e-08 5.662858e-07 7 44767516 44768697 1182 + 2.934 3.150 0.717
ENSG00000122515 E048 127.3067959 0.0074918354 7.554740e-02 1.523907e-01 7 44768698 44769114 417 + 2.117 2.059 -0.196
ENSG00000122515 E049 78.1284270 0.0092078911 7.492732e-02 1.514140e-01 7 44769115 44769454 340 + 1.913 1.841 -0.242
ENSG00000122515 E050 132.0266836 0.0010823642 3.402016e-01 4.841667e-01 7 44769455 44769881 427 + 2.094 2.092 -0.006