ENSG00000122512

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265849 ENSG00000122512 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS2 protein_coding protein_coding 8.096024 5.640083 10.61035 0.4039163 0.1957609 0.910487 6.2407235 5.40946464 7.4544340 0.46658759 0.09823774 0.4618825 0.81756250 0.957266667 0.70336667 -0.2539000 6.559161e-08 3.717285e-09 FALSE TRUE
ENST00000642456 ENSG00000122512 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS2 protein_coding protein_coding 8.096024 5.640083 10.61035 0.4039163 0.1957609 0.910487 0.7560054 0.01503666 1.5547538 0.01503666 0.29579195 5.9657500 0.07365417 0.002800000 0.14743333 0.1446333 3.717285e-09 3.717285e-09 FALSE TRUE
ENST00000643595 ENSG00000122512 HEK293_OSMI2_2hA HEK293_TMG_2hB PMS2 protein_coding nonsense_mediated_decay 8.096024 5.640083 10.61035 0.4039163 0.1957609 0.910487 0.3916554 0.01675242 0.9266075 0.01675242 0.46401457 5.1297031 0.03581250 0.003133333 0.08613333 0.0830000 4.122702e-01 3.717285e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122512 E001 1.5961430 0.0439918608 7.053292e-01 8.037250e-01 7 5970925 5971714 790 - 0.377 0.453 0.409
ENSG00000122512 E002 0.8995276 0.2580515034 4.700396e-01 6.092598e-01 7 5971715 5971770 56 - 0.334 0.162 -1.352
ENSG00000122512 E003 68.7740932 0.0113662570 3.425788e-07 3.132416e-06 7 5971771 5973192 1422 - 1.673 2.013 1.147
ENSG00000122512 E004 17.2485069 0.0011070442 6.494289e-02 1.349409e-01 7 5973193 5973241 49 - 1.184 1.345 0.566
ENSG00000122512 E005 14.5086933 0.0017514266 4.200562e-01 5.632791e-01 7 5973242 5973246 5 - 1.150 1.233 0.293
ENSG00000122512 E006 22.7639497 0.0008791087 3.905110e-03 1.287771e-02 7 5973247 5973273 27 - 1.273 1.490 0.752
ENSG00000122512 E007 39.2331516 0.0034833728 2.065776e-02 5.286430e-02 7 5973274 5973360 87 - 1.528 1.680 0.519
ENSG00000122512 E008 24.8925394 0.0124008677 9.281847e-02 1.795312e-01 7 5973361 5973398 38 - 1.337 1.494 0.540
ENSG00000122512 E009 44.2522373 0.0005557171 1.776988e-02 4.664482e-02 7 5973399 5973542 144 - 1.589 1.724 0.460
ENSG00000122512 E010 41.0617239 0.0069218052 9.200700e-02 1.782423e-01 7 5977588 5977673 86 - 1.562 1.681 0.404
ENSG00000122512 E011 49.1154821 0.0006686261 1.621654e-01 2.779272e-01 7 5977674 5977714 41 - 1.658 1.739 0.275
ENSG00000122512 E012 59.9105246 0.0004313530 1.203666e-01 2.204993e-01 7 5977715 5977757 43 - 1.743 1.824 0.274
ENSG00000122512 E013 52.5135695 0.0005825528 1.742762e-01 2.937428e-01 7 5978596 5978696 101 - 1.683 1.760 0.261
ENSG00000122512 E014 16.0997986 0.0090469117 2.579693e-01 3.951735e-01 7 5982824 5982874 51 - 1.171 1.288 0.413
ENSG00000122512 E015 13.2657270 0.0037967754 6.740815e-01 7.796098e-01 7 5982875 5982905 31 - 1.121 1.170 0.177
ENSG00000122512 E016 26.6021823 0.0167121095 8.128942e-01 8.813720e-01 7 5982906 5982991 86 - 1.435 1.414 -0.073
ENSG00000122512 E017 81.2343864 0.0008412010 8.148070e-02 1.618745e-01 7 5986759 5987086 328 - 1.926 1.864 -0.208
ENSG00000122512 E018 116.7757455 0.0003532890 8.520479e-02 1.677453e-01 7 5987087 5987620 534 - 2.077 2.030 -0.157
ENSG00000122512 E019 42.0683391 0.0089212583 7.916322e-01 8.667319e-01 7 5989800 5989955 156 - 1.613 1.636 0.080
ENSG00000122512 E020 33.6037836 0.0007155135 4.016502e-01 5.453438e-01 7 5991973 5992057 85 - 1.500 1.561 0.209
ENSG00000122512 E021 37.1364329 0.0052393719 8.996285e-01 9.399466e-01 7 5995534 5995633 100 - 1.567 1.567 -0.002
ENSG00000122512 E022 32.5619609 0.0214201774 3.346836e-01 4.784223e-01 7 5997326 5997423 98 - 1.545 1.465 -0.277
ENSG00000122512 E023 41.4048374 0.0005079988 2.323694e-02 5.823976e-02 7 5999108 5999226 119 - 1.658 1.539 -0.405
ENSG00000122512 E024 25.6019855 0.0039247547 2.964740e-01 4.376954e-01 7 5999227 5999275 49 - 1.435 1.364 -0.248
ENSG00000122512 E025 0.1817044 0.0395663599 2.503838e-01   7 6001966 6002452 487 - 0.000 0.164 11.223
ENSG00000122512 E026 47.4794886 0.0005750874 1.380177e-04 6.948223e-04 7 6002453 6002636 184 - 1.738 1.539 -0.677
ENSG00000122512 E027 2.2906702 0.0065911293 8.863447e-01 9.313163e-01 7 6003310 6003689 380 - 0.488 0.519 0.150
ENSG00000122512 E028 41.4261214 0.0005944220 8.341497e-04 3.380983e-03 7 6003690 6003792 103 - 1.675 1.490 -0.631
ENSG00000122512 E029 0.2987644 0.0293813366 4.574972e-01   7 6003793 6003971 179 - 0.165 0.000 -10.744
ENSG00000122512 E030 49.0798522 0.0006114453 3.897199e-02 8.914127e-02 7 6003972 6004058 87 - 1.725 1.627 -0.331
ENSG00000122512 E031 48.1755357 0.0009652144 1.735744e-02 4.572947e-02 7 6005892 6005992 101 - 1.725 1.608 -0.398
ENSG00000122512 E032 31.4741174 0.0006630913 1.522366e-04 7.568762e-04 7 6005993 6006026 34 - 1.581 1.336 -0.842
ENSG00000122512 E033 21.0648786 0.0044223357 1.140910e-02 3.213877e-02 7 6006027 6006031 5 - 1.401 1.196 -0.719
ENSG00000122512 E034 0.1515154 0.0428463776 1.000000e+00   7 6006032 6006066 35 - 0.090 0.000 -9.758
ENSG00000122512 E035 27.7314523 0.0019612927 2.739829e-03 9.491853e-03 7 6008997 6009106 110 - 1.516 1.308 -0.720