ENSG00000122483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000447456 ENSG00000122483 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC18 protein_coding retained_intron 9.478456 4.733268 14.82383 0.5875837 0.8243879 1.644937 2.2120812 2.2696878 2.4711474 0.07340809 0.2914034 0.12217116 0.27718750 0.49540000 0.16766667 -0.32773333 1.043386e-04 5.36406e-07 FALSE FALSE
ENST00000455267 ENSG00000122483 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC18 protein_coding protein_coding 9.478456 4.733268 14.82383 0.5875837 0.8243879 1.644937 0.7977641 0.1394969 1.2323436 0.13949692 0.2112638 3.05487654 0.07478333 0.02970000 0.08420000 0.05450000 2.660694e-01 5.36406e-07 FALSE TRUE
ENST00000688770 ENSG00000122483 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC18 protein_coding nonsense_mediated_decay 9.478456 4.733268 14.82383 0.5875837 0.8243879 1.644937 0.7199245 0.3847001 0.7825348 0.23018524 0.6177658 1.00571729 0.08136667 0.07140000 0.04883333 -0.02256667 8.774839e-01 5.36406e-07 FALSE TRUE
MSTRG.1630.10 ENSG00000122483 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC18 protein_coding   9.478456 4.733268 14.82383 0.5875837 0.8243879 1.644937 1.6454517 0.4689898 3.6349962 0.23719733 0.2120321 2.92785055 0.14957917 0.09136667 0.24826667 0.15690000 3.651373e-01 5.36406e-07 FALSE TRUE
MSTRG.1630.14 ENSG00000122483 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC18 protein_coding   9.478456 4.733268 14.82383 0.5875837 0.8243879 1.644937 0.5751012 0.1618307 1.0854836 0.08567116 0.1235329 2.67250843 0.05798750 0.03723333 0.07356667 0.03633333 4.228920e-01 5.36406e-07 FALSE TRUE
MSTRG.1630.15 ENSG00000122483 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC18 protein_coding   9.478456 4.733268 14.82383 0.5875837 0.8243879 1.644937 0.5373661 0.0000000 1.3704702 0.00000000 0.2420588 7.10901591 0.04215417 0.00000000 0.09386667 0.09386667 5.364060e-07 5.36406e-07 FALSE TRUE
MSTRG.1630.21 ENSG00000122483 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC18 protein_coding   9.478456 4.733268 14.82383 0.5875837 0.8243879 1.644937 1.0148403 0.7079441 0.7418448 0.20637396 0.1875663 0.06656331 0.12707083 0.15196667 0.04976667 -0.10220000 7.655828e-02 5.36406e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122483 E001 0.5922303 0.0180119894 7.503456e-01 8.370473e-01 1 93179919 93179929 11 + 0.168 0.223 0.513
ENSG00000122483 E002 3.3946831 0.0046896120 4.007061e-02 9.116000e-02 1 93179930 93180041 112 + 0.649 0.224 -2.360
ENSG00000122483 E003 4.4245079 0.0043648579 5.827989e-02 1.236776e-01 1 93180042 93180279 238 + 0.732 0.370 -1.708
ENSG00000122483 E004 0.9557277 0.0138155420 9.108105e-01 9.473343e-01 1 93180280 93180362 83 + 0.252 0.224 -0.221
ENSG00000122483 E005 0.8042123 0.1006099942 9.656325e-01 9.824028e-01 1 93180363 93180393 31 + 0.212 0.225 0.112
ENSG00000122483 E006 0.8042123 0.1006099942 9.656325e-01 9.824028e-01 1 93180394 93180418 25 + 0.212 0.225 0.112
ENSG00000122483 E007 1.2189160 0.0113105280 2.210041e-01 3.516289e-01 1 93180419 93180611 193 + 0.252 0.480 1.361
ENSG00000122483 E008 1.8102039 0.0076972757 3.126144e-01 4.551392e-01 1 93180612 93180702 91 + 0.436 0.224 -1.360
ENSG00000122483 E009 1.3577340 0.0136263065 5.369940e-01 6.686484e-01 1 93180703 93180707 5 + 0.354 0.224 -0.900
ENSG00000122483 E010 3.2251822 0.0705314064 6.507130e-01 7.617271e-01 1 93180708 93180715 8 + 0.582 0.482 -0.472
ENSG00000122483 E011 3.3724312 0.0805258750 6.016742e-01 7.227861e-01 1 93180716 93180723 8 + 0.600 0.482 -0.549
ENSG00000122483 E012 13.7619109 0.0225821740 7.028898e-01 8.016445e-01 1 93180724 93180758 35 + 1.101 1.048 -0.191
ENSG00000122483 E013 14.7721558 0.0072335741 4.427702e-01 5.843363e-01 1 93180759 93180768 10 + 1.138 1.046 -0.330
ENSG00000122483 E014 22.4359623 0.0008484761 9.525313e-01 9.742800e-01 1 93180769 93180852 84 + 1.291 1.283 -0.028
ENSG00000122483 E015 8.9293431 0.0019663232 3.995790e-02 9.095818e-02 1 93180853 93180882 30 + 0.853 1.095 0.902
ENSG00000122483 E016 34.9647248 0.0029279203 2.873665e-01 4.278637e-01 1 93180883 93182449 1567 + 1.457 1.532 0.255
ENSG00000122483 E017 6.1800323 0.0689774292 6.779536e-01 7.825458e-01 1 93182450 93182482 33 + 0.804 0.704 -0.404
ENSG00000122483 E018 31.2742587 0.0006727661 8.293727e-02 1.641460e-01 1 93183360 93183495 136 + 1.455 1.313 -0.493
ENSG00000122483 E019 34.0425514 0.0005854853 8.369917e-04 3.391341e-03 1 93183978 93184146 169 + 1.513 1.235 -0.967
ENSG00000122483 E020 36.5903542 0.0015973942 3.073741e-03 1.048340e-02 1 93186345 93186503 159 + 1.538 1.298 -0.827
ENSG00000122483 E021 29.7046501 0.0025405879 4.585865e-05 2.607769e-04 1 93192000 93192106 107 + 1.467 1.071 -1.391
ENSG00000122483 E022 24.5244311 0.0034030019 2.062449e-04 9.907637e-04 1 93193616 93193654 39 + 1.385 0.990 -1.408
ENSG00000122483 E023 30.9207312 0.0728494508 2.223941e-02 5.617287e-02 1 93193655 93193744 90 + 1.472 1.161 -1.086
ENSG00000122483 E024 30.0753061 0.0250713608 1.063554e-02 3.029789e-02 1 93201892 93201988 97 + 1.460 1.166 -1.028
ENSG00000122483 E025 0.7749669 0.1445271019 9.350073e-01 9.630895e-01 1 93203037 93203139 103 + 0.212 0.224 0.102
ENSG00000122483 E026 18.4725415 0.0009841946 7.160549e-03 2.163893e-02 1 93205510 93205554 45 + 1.258 0.958 -1.083
ENSG00000122483 E027 22.2714038 0.0008616311 2.119442e-02 5.400454e-02 1 93205555 93205631 77 + 1.325 1.095 -0.812
ENSG00000122483 E028 50.8517712 0.0004701507 1.145896e-01 2.122453e-01 1 93207107 93207398 292 + 1.650 1.549 -0.346
ENSG00000122483 E029 0.0000000       1 93207399 93207402 4 +      
ENSG00000122483 E030 17.2504127 0.0010239290 1.275436e-01 2.307345e-01 1 93210802 93210849 48 + 1.211 1.046 -0.593
ENSG00000122483 E031 28.8311471 0.0035455254 2.807509e-01 4.206301e-01 1 93210850 93210926 77 + 1.407 1.314 -0.323
ENSG00000122483 E032 50.5706514 0.0044997392 7.548706e-02 1.522917e-01 1 93212101 93212261 161 + 1.651 1.525 -0.427
ENSG00000122483 E033 20.7011613 0.0025171847 5.806758e-02 1.233224e-01 1 93214743 93214745 3 + 1.291 1.096 -0.695
ENSG00000122483 E034 60.6720296 0.0062426259 9.455165e-02 1.822156e-01 1 93214746 93214961 216 + 1.727 1.614 -0.386
ENSG00000122483 E035 18.1759765 0.0009709078 2.076334e-01 3.356360e-01 1 93214962 93214966 5 + 1.227 1.095 -0.471
ENSG00000122483 E036 33.9729894 0.0006296727 2.371485e-01 3.708813e-01 1 93216636 93216746 111 + 1.483 1.391 -0.318
ENSG00000122483 E037 38.6984837 0.0005554332 1.259681e-01 2.285303e-01 1 93217738 93217869 132 + 1.538 1.425 -0.387
ENSG00000122483 E038 3.3289009 0.0046359201 2.842368e-01 4.244543e-01 1 93218503 93218652 150 + 0.526 0.703 0.778
ENSG00000122483 E039 3.1075810 0.0587159518 2.374062e-01 3.711679e-01 1 93220311 93220470 160 + 0.484 0.706 0.997
ENSG00000122483 E040 33.3246135 0.0054460874 4.050019e-03 1.328067e-02 1 93221609 93221664 56 + 1.496 1.236 -0.903
ENSG00000122483 E041 35.5904434 0.0090953282 6.167633e-02 1.294455e-01 1 93221665 93221743 79 + 1.512 1.343 -0.584
ENSG00000122483 E042 38.3196634 0.0012576959 5.323729e-02 1.149060e-01 1 93221859 93221936 78 + 1.538 1.391 -0.504
ENSG00000122483 E043 0.0000000       1 93221937 93221940 4 +      
ENSG00000122483 E044 24.8149787 0.0007969730 5.260786e-01 6.593498e-01 1 93226333 93226337 5 + 1.341 1.283 -0.200
ENSG00000122483 E045 44.1708610 0.0004904529 2.826453e-01 4.226728e-01 1 93226338 93226449 112 + 1.588 1.514 -0.252
ENSG00000122483 E046 36.7488768 0.0006378127 2.299873e-01 3.624494e-01 1 93232426 93232495 70 + 1.515 1.425 -0.311
ENSG00000122483 E047 46.9090493 0.0029332069 1.147483e-01 2.124623e-01 1 93232496 93232593 98 + 1.619 1.506 -0.385
ENSG00000122483 E048 58.6265954 0.0004214893 2.756247e-01 4.149616e-01 1 93236248 93236390 143 + 1.703 1.638 -0.222
ENSG00000122483 E049 1.9543299 0.0072438620 6.015321e-01 7.226602e-01 1 93237262 93237380 119 + 0.383 0.480 0.516
ENSG00000122483 E050 62.3294941 0.0006967518 6.363164e-01 7.503547e-01 1 93239310 93239473 164 + 1.711 1.735 0.078
ENSG00000122483 E051 73.0364902 0.0007985398 4.572715e-01 5.976248e-01 1 93239683 93239896 214 + 1.779 1.813 0.116
ENSG00000122483 E052 48.0652565 0.0005597966 1.099468e-02 3.114909e-02 1 93246105 93246204 100 + 1.566 1.712 0.497
ENSG00000122483 E053 51.7234955 0.0006414526 8.012664e-04 3.264184e-03 1 93246838 93246954 117 + 1.586 1.771 0.627
ENSG00000122483 E054 38.2587383 0.0100330921 1.560361e-01 2.698438e-01 1 93254471 93254516 46 + 1.485 1.597 0.383
ENSG00000122483 E055 59.4541368 0.0069448305 2.631842e-04 1.229641e-03 1 93254517 93254614 98 + 1.639 1.865 0.762
ENSG00000122483 E056 81.4199750 0.0004650203 5.783270e-14 1.700486e-12 1 93256335 93256538 204 + 1.740 2.055 1.062
ENSG00000122483 E057 59.0138841 0.0004886732 1.056685e-11 2.192135e-10 1 93258748 93258885 138 + 1.593 1.927 1.130
ENSG00000122483 E058 48.6418894 0.0027492517 2.975624e-09 4.039578e-08 1 93264701 93264901 201 + 1.509 1.853 1.167
ENSG00000122483 E059 3.3559944 0.0051827570 4.168232e-02 9.415723e-02 1 93264902 93264947 46 + 0.483 0.805 1.399
ENSG00000122483 E060 14.4614168 0.0051129756 4.883795e-02 1.070919e-01 1 93270347 93270814 468 + 1.050 1.253 0.726
ENSG00000122483 E061 9.2086414 0.0019024069 1.074495e-01 2.017791e-01 1 93278463 93278518 56 + 0.881 1.071 0.708
ENSG00000122483 E062 6.9729765 0.0142772317 2.966161e-02 7.129936e-02 1 93278519 93278730 212 + 0.757 1.044 1.095
ENSG00000122483 E063 0.2944980 0.3507682491 1.000000e+00   1 93286959 93287028 70 + 0.119 0.000 -8.530
ENSG00000122483 E064 0.2987644 0.0271631140 1.000000e+00   1 93287138 93287252 115 + 0.119 0.000 -8.532