ENSG00000122359

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000463340 ENSG00000122359 HEK293_OSMI2_2hA HEK293_TMG_2hB ANXA11 protein_coding processed_transcript 96.72271 208.5896 44.86279 4.383072 1.086949 -2.216824 3.563068 12.74837 0.3420703 7.398327 0.3420703 -5.179436 0.0260375 0.05986667 0.0079000 -0.05196667 0.139954496 6.487871e-05   FALSE
MSTRG.4269.6 ENSG00000122359 HEK293_OSMI2_2hA HEK293_TMG_2hB ANXA11 protein_coding   96.72271 208.5896 44.86279 4.383072 1.086949 -2.216824 54.840861 105.20113 29.7607294 4.163112 1.3024598 -1.821321 0.6072708 0.50506667 0.6632333 0.15816667 0.004264605 6.487871e-05 FALSE TRUE
MSTRG.4269.9 ENSG00000122359 HEK293_OSMI2_2hA HEK293_TMG_2hB ANXA11 protein_coding   96.72271 208.5896 44.86279 4.383072 1.086949 -2.216824 27.236231 67.15230 8.3744906 2.420792 0.8911794 -3.001857 0.2390542 0.32233333 0.1861000 -0.13623333 0.000197707 6.487871e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122359 E001 215.8946432 5.213227e-03 3.061385e-20 2.009599e-18 10 80150889 80155123 4235 - 2.507 2.107 -1.334
ENSG00000122359 E002 121.7683654 2.571180e-04 3.666896e-02 8.484463e-02 10 80155124 80155587 464 - 2.020 1.935 -0.286
ENSG00000122359 E003 104.8707184 1.044198e-03 3.267768e-01 4.702242e-01 10 80155588 80155611 24 - 1.846 1.895 0.164
ENSG00000122359 E004 251.4651521 4.125886e-03 3.402723e-01 4.842407e-01 10 80155612 80155639 28 - 2.228 2.270 0.141
ENSG00000122359 E005 1526.0598057 2.913960e-03 2.475286e-03 8.689461e-03 10 80155640 80155912 273 - 2.970 3.056 0.286
ENSG00000122359 E006 17.3598303 4.756501e-03 4.133408e-01 5.568492e-01 10 80156378 80156498 121 - 1.210 1.126 -0.300
ENSG00000122359 E007 1349.3461066 1.072690e-03 1.342465e-03 5.118045e-03 10 80157641 80157763 123 - 2.934 2.999 0.216
ENSG00000122359 E008 1004.7509494 3.811335e-04 2.122533e-05 1.308135e-04 10 80157967 80158025 59 - 2.797 2.873 0.252
ENSG00000122359 E009 1222.2007889 9.481486e-05 2.396854e-09 3.312495e-08 10 80159100 80159195 96 - 2.873 2.958 0.285
ENSG00000122359 E010 1128.8656775 1.623086e-04 2.873566e-04 1.328522e-03 10 80161935 80162028 94 - 2.863 2.919 0.184
ENSG00000122359 E011 842.3262804 3.402597e-04 1.822656e-01 3.040440e-01 10 80163349 80163405 57 - 2.762 2.787 0.082
ENSG00000122359 E012 978.6255811 9.419734e-04 8.496055e-01 9.066723e-01 10 80163534 80163613 80 - 2.845 2.850 0.016
ENSG00000122359 E013 991.8236333 4.474517e-04 3.618942e-01 5.063072e-01 10 80164053 80164143 91 - 2.867 2.852 -0.051
ENSG00000122359 E014 903.9143808 1.147902e-04 2.671906e-02 6.540613e-02 10 80166084 80166197 114 - 2.843 2.809 -0.115
ENSG00000122359 E015 8.6970361 6.877131e-03 1.839436e-01 3.061691e-01 10 80166399 80166889 491 - 1.000 0.824 -0.665
ENSG00000122359 E016 801.5910584 8.872852e-05 4.276215e-05 2.448590e-04 10 80166890 80166984 95 - 2.818 2.752 -0.219
ENSG00000122359 E017 585.1835965 1.633494e-04 4.823915e-06 3.447939e-05 10 80167226 80167313 88 - 2.698 2.611 -0.291
ENSG00000122359 E018 657.8819546 2.079627e-03 3.216738e-01 4.649292e-01 10 80168969 80169079 111 - 2.700 2.673 -0.090
ENSG00000122359 E019 1004.9113621 8.755211e-04 8.564772e-01 9.112531e-01 10 80169080 80169358 279 - 2.857 2.862 0.014
ENSG00000122359 E020 593.5404336 1.822290e-03 1.678783e-01 2.854274e-01 10 80170800 80170915 116 - 2.664 2.628 -0.120
ENSG00000122359 E021 1.9050346 6.368423e-02 1.945596e-01 3.194523e-01 10 80171613 80171881 269 - 0.576 0.318 -1.357
ENSG00000122359 E022 345.2326066 9.318365e-04 1.189537e-02 3.328187e-02 10 80172807 80172833 27 - 2.456 2.386 -0.234
ENSG00000122359 E023 368.9164009 2.425412e-03 1.151593e-02 3.238660e-02 10 80172834 80172869 36 - 2.495 2.413 -0.274
ENSG00000122359 E024 0.9211812 1.369686e-02 3.471641e-01 4.913486e-01 10 80172870 80173021 152 - 0.000 0.247 10.448
ENSG00000122359 E025 221.0212795 1.739555e-03 5.871277e-02 1.244248e-01 10 80176107 80176155 49 - 2.261 2.193 -0.227
ENSG00000122359 E026 26.4991466 4.293499e-02 9.576192e-01 9.774366e-01 10 80180941 80181023 83 - 1.323 1.301 -0.076
ENSG00000122359 E027 20.3477347 4.083737e-02 9.188587e-01 9.527499e-01 10 80181024 80181101 78 - 1.191 1.195 0.016
ENSG00000122359 E028 13.1531357 3.241863e-02 3.680761e-01 5.124768e-01 10 80181102 80181136 35 - 0.898 1.033 0.501
ENSG00000122359 E029 32.7236669 1.538483e-02 8.336698e-01 8.958298e-01 10 80181137 80181455 319 - 1.364 1.389 0.085
ENSG00000122359 E030 0.0000000       10 80195731 80195832 102 -      
ENSG00000122359 E031 8.7950164 3.437714e-03 9.345959e-01 9.628030e-01 10 80201259 80201393 135 - 0.859 0.871 0.046
ENSG00000122359 E032 0.1817044 3.989779e-02 1.000000e+00   10 80204826 80204919 94 - 0.000 0.062 7.616
ENSG00000122359 E033 350.0805858 8.748244e-03 5.111366e-04 2.201368e-03 10 80205343 80205572 230 - 2.544 2.373 -0.570