ENSG00000122257

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319715 ENSG00000122257 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP6 protein_coding protein_coding 31.03403 19.79076 44.6988 0.9397156 0.9327861 1.175003 14.899227 8.384122 22.98782937 1.1463722 1.15737417 1.4540464 0.47730000 0.42766667 0.5144333333 0.08676667 6.036517e-01 9.06623e-16 FALSE TRUE
ENST00000348022 ENSG00000122257 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP6 protein_coding protein_coding 31.03403 19.79076 44.6988 0.9397156 0.9327861 1.175003 7.324426 1.810452 13.62656627 0.9080630 0.90579002 2.9051119 0.20530833 0.09370000 0.3049333333 0.21123333 4.453216e-01 9.06623e-16 FALSE TRUE
ENST00000381039 ENSG00000122257 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP6 protein_coding protein_coding 31.03403 19.79076 44.6988 0.9397156 0.9327861 1.175003 1.410907 3.924615 0.03549973 0.7902390 0.03549973 -6.4342207 0.06904583 0.19643333 0.0008333333 -0.19560000 9.066230e-16 9.06623e-16 FALSE TRUE
ENST00000452655 ENSG00000122257 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP6 protein_coding protein_coding 31.03403 19.79076 44.6988 0.9397156 0.9327861 1.175003 1.973960 1.288375 2.34851385 0.3682533 0.20105455 0.8611706 0.06591667 0.06403333 0.0525000000 -0.01153333 8.375721e-01 9.06623e-16 FALSE TRUE
ENST00000562683 ENSG00000122257 HEK293_OSMI2_2hA HEK293_TMG_2hB RBBP6 protein_coding protein_coding 31.03403 19.79076 44.6988 0.9397156 0.9327861 1.175003 2.112748 1.843299 2.03388405 0.5520201 0.37370158 0.1412174 0.07062500 0.09083333 0.0453333333 -0.04550000 3.290150e-01 9.06623e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122257 E001 0.0000000       16 24537693 24537711 19 +      
ENSG00000122257 E002 0.0000000       16 24537712 24537739 28 +      
ENSG00000122257 E003 4.7650484 0.0935469095 4.988893e-01 6.352846e-01 16 24537740 24537933 194 + 0.704 0.821 0.469
ENSG00000122257 E004 5.4177413 0.0031851257 1.122577e-02 3.170653e-02 16 24539556 24539565 10 + 0.648 0.971 1.276
ENSG00000122257 E005 10.5313945 0.0019257175 4.378400e-04 1.919992e-03 16 24539566 24539576 11 + 0.886 1.235 1.273
ENSG00000122257 E006 20.5915013 0.0042396538 5.195341e-03 1.646164e-02 16 24539577 24539584 8 + 1.215 1.434 0.763
ENSG00000122257 E007 37.0372365 0.0005875715 1.830301e-03 6.696303e-03 16 24539585 24539598 14 + 1.483 1.657 0.593
ENSG00000122257 E008 72.8148655 0.0003850622 1.001888e-07 1.016956e-06 16 24539599 24539623 25 + 1.754 1.970 0.728
ENSG00000122257 E009 134.3595699 0.0009646853 1.376589e-07 1.361973e-06 16 24539624 24539759 136 + 2.037 2.207 0.567
ENSG00000122257 E010 158.6394212 0.0032863101 1.775459e-04 8.677452e-04 16 24539760 24540001 242 + 2.123 2.260 0.458
ENSG00000122257 E011 101.9502856 0.0039987441 1.986762e-03 7.185134e-03 16 24540002 24540145 144 + 1.935 2.068 0.447
ENSG00000122257 E012 256.9548224 0.0047231183 2.830522e-03 9.765686e-03 16 24540146 24540495 350 + 2.344 2.451 0.358
ENSG00000122257 E013 66.5225447 0.0003934596 5.250143e-01 6.584253e-01 16 24540496 24540519 24 + 1.794 1.811 0.055
ENSG00000122257 E014 77.0874446 0.0004115790 6.059664e-01 7.262475e-01 16 24540520 24540573 54 + 1.874 1.838 -0.123
ENSG00000122257 E015 44.7777827 0.0006348797 4.821497e-03 1.543405e-02 16 24540574 24540582 9 + 1.680 1.495 -0.631
ENSG00000122257 E016 61.7792593 0.0003662649 4.522894e-03 1.460704e-02 16 24540583 24540611 29 + 1.811 1.652 -0.539
ENSG00000122257 E017 154.4845642 0.0002165221 2.062024e-04 9.906027e-04 16 24540612 24540792 181 + 2.198 2.064 -0.450
ENSG00000122257 E018 135.6461624 0.0012141825 1.193086e-02 3.336629e-02 16 24546163 24546262 100 + 2.137 2.029 -0.361
ENSG00000122257 E019 119.4786846 0.0060238526 1.779210e-02 4.669085e-02 16 24548945 24548981 37 + 2.091 1.954 -0.459
ENSG00000122257 E020 26.1224025 0.0746343923 9.878877e-02 1.886352e-01 16 24548982 24549401 420 + 1.303 1.572 0.928
ENSG00000122257 E021 8.9306948 0.1813076670 7.545255e-01 8.401469e-01 16 24552993 24553255 263 + 0.979 0.972 -0.030
ENSG00000122257 E022 5.9642352 0.1178420804 3.567875e-01 5.011702e-01 16 24553256 24553512 257 + 0.875 0.701 -0.690
ENSG00000122257 E023 115.7031149 0.0002703596 2.745925e-04 1.276425e-03 16 24553513 24553557 45 + 2.078 1.927 -0.507
ENSG00000122257 E024 39.9097429 0.0818892685 5.190640e-02 1.125618e-01 16 24553558 24554476 919 + 1.453 1.778 1.108
ENSG00000122257 E025 26.1704752 0.0955231654 1.590913e-01 2.738971e-01 16 24554477 24555614 1138 + 1.303 1.573 0.933
ENSG00000122257 E026 150.1372048 0.0002146130 6.423825e-07 5.559245e-06 16 24555615 24555703 89 + 2.197 2.016 -0.605
ENSG00000122257 E027 89.0584672 0.0005135114 1.018632e-05 6.757600e-05 16 24555821 24555829 9 + 1.980 1.770 -0.706
ENSG00000122257 E028 150.8035139 0.0004053363 1.663401e-04 8.194893e-04 16 24555830 24555917 88 + 2.190 2.050 -0.470
ENSG00000122257 E029 162.1556744 0.0005006512 2.507314e-03 8.785291e-03 16 24556308 24556447 140 + 2.214 2.101 -0.375
ENSG00000122257 E030 0.4418608 0.0267574256 3.701884e-01 5.146254e-01 16 24558421 24558534 114 + 0.206 0.000 -9.661
ENSG00000122257 E031 164.9909866 0.0002396456 5.804685e-05 3.218857e-04 16 24559505 24559677 173 + 2.228 2.087 -0.472
ENSG00000122257 E032 11.8695657 0.0534634621 5.092971e-04 2.194333e-03 16 24559678 24559805 128 + 0.851 1.351 1.816
ENSG00000122257 E033 118.7812921 0.0002630199 1.087373e-14 3.557070e-13 16 24561612 24561715 104 + 2.126 1.804 -1.083
ENSG00000122257 E034 206.5719158 0.0066109886 1.099005e-11 2.273954e-10 16 24561824 24562161 338 + 2.370 2.019 -1.176
ENSG00000122257 E035 62.6189704 0.0049546428 1.399040e-06 1.125165e-05 16 24563199 24563279 81 + 1.850 1.525 -1.102
ENSG00000122257 E036 44.5160887 0.0127528018 7.839093e-03 2.337808e-02 16 24563280 24563295 16 + 1.684 1.455 -0.779
ENSG00000122257 E037 0.0000000       16 24563296 24563422 127 +      
ENSG00000122257 E038 78.0675647 0.0132533546 5.402735e-04 2.310888e-03 16 24563423 24563501 79 + 1.932 1.670 -0.882
ENSG00000122257 E039 79.1870019 0.0381166799 9.153317e-03 2.666526e-02 16 24563610 24563664 55 + 1.940 1.675 -0.893
ENSG00000122257 E040 99.4162475 0.0547485477 5.422066e-02 1.166338e-01 16 24564797 24564865 69 + 2.025 1.822 -0.682
ENSG00000122257 E041 274.6610067 0.0295269653 1.092060e-03 4.277098e-03 16 24567143 24567505 363 + 2.478 2.211 -0.893
ENSG00000122257 E042 68.4651135 0.0182822710 1.301230e-02 3.593920e-02 16 24567792 24567893 102 + 1.863 1.657 -0.696
ENSG00000122257 E043 1295.1325889 0.0058235624 4.965135e-03 1.583316e-02 16 24568745 24570499 1755 + 3.109 3.017 -0.307
ENSG00000122257 E044 1648.7603898 0.0004180610 2.954711e-76 5.434575e-73 16 24570876 24572863 1988 + 3.116 3.303 0.619