ENSG00000122203

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298569 ENSG00000122203 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1191 protein_coding protein_coding 81.74356 92.97336 88.73534 8.547267 0.8420707 -0.06730127 36.179913 38.417965 43.276059 4.5855635 1.9787922 0.1717459 0.44257917 0.41106667 0.48760000 0.07653333 1.576357e-01 4.685265e-07 FALSE TRUE
ENST00000393725 ENSG00000122203 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1191 protein_coding protein_coding 81.74356 92.97336 88.73534 8.547267 0.8420707 -0.06730127 12.414582 14.396073 17.101085 2.5990711 1.0465123 0.2482541 0.14975000 0.15440000 0.19296667 0.03856667 5.152291e-01 4.685265e-07 FALSE TRUE
ENST00000393728 ENSG00000122203 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1191 protein_coding processed_transcript 81.74356 92.97336 88.73534 8.547267 0.8420707 -0.06730127 11.673321 19.226658 5.020155 3.2074104 0.8538035 -1.9351834 0.14357500 0.20580000 0.05643333 -0.14936667 4.685265e-07 4.685265e-07 TRUE FALSE
ENST00000620366 ENSG00000122203 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1191 protein_coding protein_coding 81.74356 92.97336 88.73534 8.547267 0.8420707 -0.06730127 5.563766 8.103209 3.153138 1.5579042 0.1950504 -1.3589163 0.06892917 0.08990000 0.03560000 -0.05430000 4.611290e-02 4.685265e-07 FALSE TRUE
MSTRG.27351.10 ENSG00000122203 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1191 protein_coding   81.74356 92.97336 88.73534 8.547267 0.8420707 -0.06730127 4.796109 3.493822 7.340404 0.2714195 0.3892589 1.0688940 0.05833333 0.03883333 0.08280000 0.04396667 4.022484e-03 4.685265e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122203 E001 8.656988 0.0031107708 6.702938e-10 1.027305e-08 5 176346062 176346064 3 - 0.300 1.204 3.911
ENSG00000122203 E002 2943.097376 0.0035714449 1.111265e-11 2.297565e-10 5 176346065 176347205 1141 - 3.345 3.544 0.658
ENSG00000122203 E003 201.831697 0.0005356472 4.511490e-16 1.782086e-14 5 176347206 176347224 19 - 2.133 2.412 0.933
ENSG00000122203 E004 624.934040 0.0013236007 1.677522e-05 1.058633e-04 5 176347225 176347493 269 - 2.711 2.854 0.476
ENSG00000122203 E005 964.518640 0.0006263485 9.990897e-02 1.903500e-01 5 176347494 176347808 315 - 2.972 2.995 0.077
ENSG00000122203 E006 495.205329 0.0008342730 2.009871e-03 7.256795e-03 5 176347921 176347968 48 - 2.704 2.689 -0.047
ENSG00000122203 E007 563.520001 0.0003328974 3.533764e-02 8.229795e-02 5 176347969 176348063 95 - 2.743 2.759 0.054
ENSG00000122203 E008 512.754712 0.0006627585 2.401130e-04 1.133788e-03 5 176348250 176348356 107 - 2.722 2.701 -0.070
ENSG00000122203 E009 476.561318 0.0017192001 6.011075e-05 3.319842e-04 5 176350613 176350727 115 - 2.707 2.655 -0.172
ENSG00000122203 E010 278.972355 0.0005041805 8.779874e-11 1.565037e-09 5 176350728 176350737 10 - 2.501 2.403 -0.326
ENSG00000122203 E011 378.576637 0.0010565159 9.555917e-11 1.691116e-09 5 176352622 176352688 67 - 2.634 2.533 -0.334
ENSG00000122203 E012 257.285878 0.0045278711 3.542387e-04 1.596530e-03 5 176352689 176352702 14 - 2.459 2.372 -0.292
ENSG00000122203 E013 338.552819 0.0017842248 6.409940e-05 3.515263e-04 5 176352703 176352748 46 - 2.564 2.507 -0.189
ENSG00000122203 E014 5.436659 0.0082841552 1.068032e-01 2.008332e-01 5 176352749 176352777 29 - 0.901 0.737 -0.646
ENSG00000122203 E015 10.498512 0.0016719041 6.755044e-01 7.807758e-01 5 176353196 176353428 233 - 1.065 1.073 0.030
ENSG00000122203 E016 504.089570 0.0002745797 1.620930e-12 3.834670e-11 5 176355571 176355749 179 - 2.742 2.674 -0.224
ENSG00000122203 E017 4.097637 0.0069656567 3.186297e-02 7.558753e-02 5 176357176 176357273 98 - 0.822 0.551 -1.141
ENSG00000122203 E018 7.548173 0.0022364885 9.694531e-01 9.849094e-01 5 176359462 176359480 19 - 0.901 0.953 0.195
ENSG00000122203 E019 229.711611 0.0001985215 6.828720e-05 3.718862e-04 5 176359481 176359519 39 - 2.388 2.348 -0.135
ENSG00000122203 E020 160.785464 0.0002750169 1.340947e-03 5.112928e-03 5 176359520 176359524 5 - 2.232 2.195 -0.125
ENSG00000122203 E021 213.778898 0.0001982924 2.912540e-04 1.344232e-03 5 176359525 176359567 43 - 2.353 2.317 -0.119
ENSG00000122203 E022 14.725241 0.0215634307 2.106346e-01 3.392888e-01 5 176359568 176359810 243 - 1.246 1.156 -0.321
ENSG00000122203 E023 415.978046 0.0021473335 1.900703e-04 9.215397e-04 5 176359811 176359918 108 - 2.649 2.594 -0.183
ENSG00000122203 E024 3.171996 0.0050540821 4.301457e-01 5.727844e-01 5 176361174 176361601 428 - 0.522 0.684 0.721
ENSG00000122203 E025 426.676584 0.0038876063 3.189233e-02 7.564580e-02 5 176361602 176361812 211 - 2.645 2.616 -0.096