ENSG00000122126

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357121 ENSG00000122126 HEK293_OSMI2_2hA HEK293_TMG_2hB OCRL protein_coding protein_coding 24.20556 27.79616 19.92155 1.796192 0.2918725 -0.4803504 10.037377 7.130870 10.5706192 1.3806857 0.64097335 0.56725239 0.4244792 0.2534667 0.53036667 0.27690000 1.756495e-04 1.317e-10 FALSE TRUE
ENST00000371113 ENSG00000122126 HEK293_OSMI2_2hA HEK293_TMG_2hB OCRL protein_coding protein_coding 24.20556 27.79616 19.92155 1.796192 0.2918725 -0.4803504 3.437403 3.994895 4.1969184 0.7431856 0.04936297 0.07099929 0.1505833 0.1426000 0.21070000 0.06810000 1.185838e-01 1.317e-10 FALSE TRUE
ENST00000463271 ENSG00000122126 HEK293_OSMI2_2hA HEK293_TMG_2hB OCRL protein_coding processed_transcript 24.20556 27.79616 19.92155 1.796192 0.2918725 -0.4803504 5.100987 11.690643 0.4002478 2.4170585 0.10793773 -4.83394832 0.1838958 0.4207000 0.01993333 -0.40076667 1.317000e-10 1.317e-10   FALSE
MSTRG.34858.3 ENSG00000122126 HEK293_OSMI2_2hA HEK293_TMG_2hB OCRL protein_coding   24.20556 27.79616 19.92155 1.796192 0.2918725 -0.4803504 4.418677 4.424836 3.8543603 0.9288303 0.69448523 -0.19865130 0.1908875 0.1631000 0.19386667 0.03076667 8.337272e-01 1.317e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122126 E001 0.0000000       X 129539849 129539939 91 +      
ENSG00000122126 E002 0.1515154 0.0433136980 4.470576e-01   X 129540171 129540226 56 + 0.116 0.000 -21.731
ENSG00000122126 E003 4.0492619 0.0067840004 2.166004e-01 3.463072e-01 X 129540227 129540258 32 + 0.746 0.651 -0.395
ENSG00000122126 E004 8.6470576 0.0692554372 6.090294e-01 7.285933e-01 X 129540259 129540274 16 + 0.965 0.982 0.064
ENSG00000122126 E005 19.8973005 0.0217026701 1.638097e-02 4.356890e-02 X 129540275 129540299 25 + 1.383 1.236 -0.516
ENSG00000122126 E006 66.2403022 0.0267047759 1.654351e-03 6.135826e-03 X 129540300 129540478 179 + 1.904 1.737 -0.566
ENSG00000122126 E007 31.9085268 0.0192720394 5.954282e-03 1.848699e-02 X 129540744 129540747 4 + 1.582 1.441 -0.483
ENSG00000122126 E008 62.9189108 0.0107553275 4.540783e-06 3.263916e-05 X 129540748 129540823 76 + 1.896 1.695 -0.680
ENSG00000122126 E009 0.1515154 0.0433136980 4.470576e-01   X 129543469 129543978 510 + 0.116 0.000 -21.736
ENSG00000122126 E010 44.4740241 0.0087194838 2.657823e-06 2.013341e-05 X 129544958 129544972 15 + 1.757 1.537 -0.747
ENSG00000122126 E011 62.6570356 0.0039279882 2.842845e-06 2.139129e-05 X 129544973 129545037 65 + 1.872 1.726 -0.493
ENSG00000122126 E012 55.7265456 0.0063298061 2.113536e-05 1.303310e-04 X 129548563 129548601 39 + 1.825 1.672 -0.517
ENSG00000122126 E013 0.0000000       X 129549648 129549917 270 +      
ENSG00000122126 E014 1.2597882 0.2882608389 6.537539e-01 7.641394e-01 X 129553236 129553273 38 + 0.347 0.321 -0.156
ENSG00000122126 E015 10.1700406 0.0020000546 5.431116e-03 1.710144e-02 X 129553274 129554393 1120 + 1.130 0.937 -0.708
ENSG00000122126 E016 1.7413037 0.0079612023 1.955267e-02 5.052351e-02 X 129554394 129554446 53 + 0.573 0.229 -1.980
ENSG00000122126 E017 0.2955422 0.0290621502 9.372621e-01   X 129555675 129555743 69 + 0.116 0.129 0.187
ENSG00000122126 E018 92.5189857 0.0011192783 1.431312e-09 2.060626e-08 X 129557325 129557435 111 + 2.035 1.899 -0.455
ENSG00000122126 E019 67.9875401 0.0003834004 9.067328e-08 9.276762e-07 X 129557861 129557950 90 + 1.899 1.774 -0.424
ENSG00000122126 E020 94.2879814 0.0036321540 2.830348e-04 1.310716e-03 X 129558633 129558753 121 + 2.010 1.946 -0.216
ENSG00000122126 E021 134.7082793 0.0007052904 2.609837e-04 1.220563e-03 X 129558840 129559001 162 + 2.138 2.123 -0.051
ENSG00000122126 E022 117.4443263 0.0002820642 7.062198e-07 6.058837e-06 X 129560550 129560651 102 + 2.103 2.045 -0.197
ENSG00000122126 E023 109.8440820 0.0002763429 2.090707e-07 1.996865e-06 X 129561179 129561243 65 + 2.080 2.008 -0.242
ENSG00000122126 E024 98.4385754 0.0003243772 5.098618e-06 3.622011e-05 X 129561244 129561293 50 + 2.026 1.966 -0.202
ENSG00000122126 E025 150.5867749 0.0002773476 2.504611e-08 2.863901e-07 X 129562384 129562500 117 + 2.209 2.149 -0.198
ENSG00000122126 E026 162.4308551 0.0022410388 5.945859e-05 3.287584e-04 X 129562599 129562786 188 + 2.232 2.192 -0.131
ENSG00000122126 E027 115.8577029 0.0003928645 3.588689e-03 1.197870e-02 X 129565772 129565883 112 + 2.063 2.069 0.019
ENSG00000122126 E028 131.2606426 0.0002606293 3.547042e-03 1.185959e-02 X 129567254 129567363 110 + 2.114 2.126 0.042
ENSG00000122126 E029 149.7515390 0.0025029133 7.138979e-02 1.456417e-01 X 129569264 129569399 136 + 2.158 2.195 0.122
ENSG00000122126 E030 165.8464508 0.0032553998 6.624548e-02 1.371316e-01 X 129575140 129575250 111 + 2.204 2.238 0.113
ENSG00000122126 E031 0.3289534 0.0288141954 9.379273e-01   X 129575654 129575719 66 + 0.116 0.130 0.190
ENSG00000122126 E032 210.1197811 0.0013484790 1.043374e-03 4.108926e-03 X 129575897 129576062 166 + 2.321 2.328 0.024
ENSG00000122126 E033 254.7920106 0.0014127834 2.120192e-03 7.596915e-03 X 129576317 129576552 236 + 2.399 2.419 0.066
ENSG00000122126 E034 2.5872696 0.0077941316 4.806860e-01 6.189139e-01 X 129576553 129576765 213 + 0.573 0.536 -0.174
ENSG00000122126 E035 24.4116710 0.0009406088 9.545291e-01 9.754913e-01 X 129584344 129584367 24 + 1.355 1.459 0.360
ENSG00000122126 E036 145.6739363 0.0016819020 7.342410e-01 8.252418e-01 X 129587002 129587118 117 + 2.118 2.211 0.311
ENSG00000122126 E037 124.2010986 0.0002781744 3.346417e-01 4.783875e-01 X 129588179 129588263 85 + 2.025 2.159 0.449
ENSG00000122126 E038 154.8472451 0.0002231599 6.387199e-01 7.523086e-01 X 129588886 129589013 128 + 2.131 2.247 0.390
ENSG00000122126 E039 4.5037951 0.0039396169 7.639486e-02 1.537384e-01 X 129589237 129589364 128 + 0.812 0.651 -0.658
ENSG00000122126 E040 3.3914819 0.0044800170 1.860304e-01 3.087745e-01 X 129589589 129589844 256 + 0.696 0.578 -0.511
ENSG00000122126 E041 153.3146222 0.0002526253 7.502526e-01 8.369922e-01 X 129589845 129589956 112 + 2.139 2.234 0.315
ENSG00000122126 E042 1709.0453148 0.0116804725 8.995810e-10 1.345090e-08 X 129590146 129592561 2416 + 3.038 3.360 1.071