ENSG00000122085

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000391980 ENSG00000122085 HEK293_OSMI2_2hA HEK293_TMG_2hB MTERF4 protein_coding protein_coding 36.40819 35.98281 39.5386 2.353096 0.7614951 0.135918 11.053379 10.074492 13.102112 1.9362691 0.4799750 0.3787617 0.30021250 0.2769000 0.3317333 0.05483333 0.5829532 0.0006516574 FALSE  
ENST00000406593 ENSG00000122085 HEK293_OSMI2_2hA HEK293_TMG_2hB MTERF4 protein_coding protein_coding 36.40819 35.98281 39.5386 2.353096 0.7614951 0.135918 6.615145 5.476980 9.445825 1.2277028 0.2118360 0.7851910 0.17757500 0.1489333 0.2390667 0.09013333 0.1780696 0.0006516574 FALSE  
ENST00000455202 ENSG00000122085 HEK293_OSMI2_2hA HEK293_TMG_2hB MTERF4 protein_coding processed_transcript 36.40819 35.98281 39.5386 2.353096 0.7614951 0.135918 4.552450 5.824500 3.985233 0.5082808 0.1231504 -0.5463293 0.12974583 0.1632000 0.1008667 -0.06233333 0.0243017 0.0006516574    
MSTRG.20177.8 ENSG00000122085 HEK293_OSMI2_2hA HEK293_TMG_2hB MTERF4 protein_coding   36.40819 35.98281 39.5386 2.353096 0.7614951 0.135918 3.135191 4.789797 2.794257 0.3396417 0.7773148 -0.7753550 0.08724583 0.1330667 0.0700000 -0.06306667 0.1688368 0.0006516574    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122085 E001 48.3958359 0.0477300772 3.739983e-02 8.622401e-02 2 241072169 241075053 2885 - 1.517 1.772 0.866
ENSG00000122085 E002 41.1943089 0.0005804258 3.580075e-02 8.319648e-02 2 241075054 241075649 596 - 1.549 1.661 0.380
ENSG00000122085 E003 24.5121055 0.0007915015 1.939458e-02 5.018775e-02 2 241075650 241075657 8 - 1.297 1.459 0.562
ENSG00000122085 E004 30.6389351 0.0006606198 7.803314e-02 1.563163e-01 2 241075658 241075682 25 - 1.430 1.537 0.368
ENSG00000122085 E005 0.1482932 0.0406725996 5.572518e-01   2 241087094 241087098 5 - 0.001 0.113 7.843
ENSG00000122085 E006 7.3267250 0.0023336191 3.317245e-01 4.753651e-01 2 241087099 241087203 105 - 0.847 0.957 0.418
ENSG00000122085 E007 6.6301096 0.0025459623 4.519110e-01 5.928233e-01 2 241087204 241087224 21 - 0.825 0.912 0.336
ENSG00000122085 E008 294.5693285 0.0034914936 1.407622e-06 1.131635e-05 2 241087225 241088904 1680 - 2.371 2.519 0.495
ENSG00000122085 E009 48.0438909 0.0025517391 1.146429e-03 4.459064e-03 2 241088905 241089040 136 - 1.570 1.748 0.602
ENSG00000122085 E010 41.9084025 0.0043138595 2.385624e-02 5.951009e-02 2 241089041 241089168 128 - 1.545 1.679 0.457
ENSG00000122085 E011 18.7787570 0.0273907649 5.240810e-01 6.577120e-01 2 241089169 241089187 19 - 1.256 1.311 0.191
ENSG00000122085 E012 59.5806040 0.0026008145 5.691014e-02 1.213062e-01 2 241089188 241089224 37 - 1.723 1.813 0.307
ENSG00000122085 E013 79.8811640 0.0042562527 1.022301e-02 2.931579e-02 2 241089225 241089266 42 - 1.828 1.950 0.408
ENSG00000122085 E014 61.5013690 0.0065867275 5.378110e-02 1.158712e-01 2 241089267 241089272 6 - 1.726 1.832 0.360
ENSG00000122085 E015 106.3295300 0.0044515598 1.843226e-01 3.066518e-01 2 241089273 241089365 93 - 1.994 2.045 0.172
ENSG00000122085 E016 79.2247325 0.0034964917 1.051548e-01 1.983281e-01 2 241089980 241090005 26 - 1.855 1.923 0.229
ENSG00000122085 E017 80.2528618 0.0025274818 2.577004e-01 3.948638e-01 2 241090006 241090044 39 - 1.878 1.921 0.145
ENSG00000122085 E018 1.6856526 0.0115575019 7.044335e-01 8.029783e-01 2 241090278 241090302 25 - 0.384 0.446 0.337
ENSG00000122085 E019 4.3363971 0.0041102889 5.477104e-01 6.777096e-01 2 241090303 241090449 147 - 0.776 0.688 -0.356
ENSG00000122085 E020 4.1468559 0.0038881131 1.860350e-02 4.846157e-02 2 241091895 241092114 220 - 0.868 0.530 -1.419
ENSG00000122085 E021 79.1486840 0.0029034026 5.002434e-02 1.092168e-01 2 241094277 241094405 129 - 1.848 1.932 0.283
ENSG00000122085 E022 43.0842899 0.0063807757 2.669053e-02 6.534641e-02 2 241094406 241094429 24 - 1.553 1.690 0.466
ENSG00000122085 E023 29.4422688 0.0010832465 7.999123e-02 1.595448e-01 2 241094430 241094432 3 - 1.412 1.521 0.376
ENSG00000122085 E024 7.3219459 0.1567302409 4.572875e-01 5.976417e-01 2 241094433 241094596 164 - 0.978 0.861 -0.444
ENSG00000122085 E025 33.9850726 0.0390599610 2.053179e-02 5.260883e-02 2 241094597 241095129 533 - 1.670 1.408 -0.898
ENSG00000122085 E026 32.3565498 0.0006021041 1.013293e-03 4.004618e-03 2 241095130 241095570 441 - 1.628 1.426 -0.694
ENSG00000122085 E027 126.2121964 0.0086324461 3.726536e-01 5.170898e-01 2 241095571 241095868 298 - 2.129 2.083 -0.152
ENSG00000122085 E028 261.4739960 0.0074311695 1.113867e-02 3.149863e-02 2 241095869 241096139 271 - 2.477 2.366 -0.372
ENSG00000122085 E029 243.7728965 0.0059240831 1.981561e-04 9.559257e-04 2 241096140 241096392 253 - 2.469 2.316 -0.511
ENSG00000122085 E030 93.8154264 0.0050579796 4.806087e-04 2.085860e-03 2 241096393 241096438 46 - 2.070 1.897 -0.581
ENSG00000122085 E031 3.8405777 0.0314462532 2.908306e-02 7.016418e-02 2 241096601 241096713 113 - 0.847 0.491 -1.524
ENSG00000122085 E032 6.3214110 0.0027273274 1.736175e-02 4.573955e-02 2 241096926 241097186 261 - 1.010 0.714 -1.143
ENSG00000122085 E033 3.8847249 0.0109055699 1.908224e-02 4.951681e-02 2 241097187 241097242 56 - 0.847 0.491 -1.527
ENSG00000122085 E034 218.1012389 0.0001994311 9.544696e-02 1.835564e-01 2 241097243 241097427 185 - 2.364 2.320 -0.147
ENSG00000122085 E035 3.6858677 0.0044170898 1.526479e-02 4.108702e-02 2 241099168 241099395 228 - 0.847 0.490 -1.530
ENSG00000122085 E036 48.5222909 0.0004674551 1.487803e-01 2.600302e-01 2 241099396 241099398 3 - 1.737 1.660 -0.259
ENSG00000122085 E037 210.1515281 0.0008540797 6.373118e-05 3.496982e-04 2 241099399 241099894 496 - 2.386 2.275 -0.369
ENSG00000122085 E038 1.2951885 0.0101888051 8.210243e-01 8.871749e-01 2 241101164 241101221 58 - 0.384 0.341 -0.250
ENSG00000122085 E039 0.7061804 0.0200319972 8.787169e-01 9.261001e-01 2 241102140 241102252 113 - 0.233 0.204 -0.247
ENSG00000122085 E040 103.3497934 0.0003922765 4.554664e-01 5.959893e-01 2 241102253 241102332 80 - 2.003 2.024 0.071