ENSG00000122068

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000241502 ENSG00000122068 HEK293_OSMI2_2hA HEK293_TMG_2hB FYTTD1 protein_coding protein_coding 14.53187 2.549782 29.17893 0.3091756 1.587929 3.511329 6.5189985 2.1112573 12.207515 0.2578738 0.5003276 2.525959 0.5518458 0.8368333 0.42063333 -0.41620000 0.08814795 0.00838324 FALSE TRUE
ENST00000412924 ENSG00000122068 HEK293_OSMI2_2hA HEK293_TMG_2hB FYTTD1 protein_coding nonsense_mediated_decay 14.53187 2.549782 29.17893 0.3091756 1.587929 3.511329 0.7930140 0.0000000 2.092099 0.0000000 0.8291517 7.715687 0.0389875 0.0000000 0.06946667 0.06946667 0.01816918 0.00838324 FALSE FALSE
ENST00000418169 ENSG00000122068 HEK293_OSMI2_2hA HEK293_TMG_2hB FYTTD1 protein_coding nonsense_mediated_decay 14.53187 2.549782 29.17893 0.3091756 1.587929 3.511329 0.3910106 0.0000000 2.365091 0.0000000 1.4498082 7.891839 0.0287125 0.0000000 0.07806667 0.07806667 0.50857486 0.00838324 TRUE TRUE
ENST00000428738 ENSG00000122068 HEK293_OSMI2_2hA HEK293_TMG_2hB FYTTD1 protein_coding protein_coding 14.53187 2.549782 29.17893 0.3091756 1.587929 3.511329 6.3586696 0.2261333 11.922298 0.1666860 1.1546212 5.659126 0.3051333 0.0894000 0.41156667 0.32216667 0.04713991 0.00838324 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122068 E001 2.9829320 0.0052518258 4.144725e-04 1.829890e-03 3 197737179 197737268 90 + 0.306 1.013 3.184
ENSG00000122068 E002 0.4375944 0.0242003127 1.000000e+00 1.000000e+00 3 197749533 197749552 20 + 0.116 0.000 -10.136
ENSG00000122068 E003 0.7708142 0.0152639653 6.697758e-01 7.764330e-01 3 197749553 197749650 98 + 0.149 0.309 1.338
ENSG00000122068 E004 4.1613447 0.0065594424 2.983209e-01 4.397619e-01 3 197749878 197749882 5 + 0.564 0.487 -0.363
ENSG00000122068 E005 33.2283358 0.0006267698 1.683774e-03 6.231288e-03 3 197749883 197749937 55 + 1.344 1.218 -0.442
ENSG00000122068 E006 52.6812363 0.0043713235 3.431997e-05 2.011514e-04 3 197749938 197749976 39 + 1.541 1.357 -0.634
ENSG00000122068 E007 89.0850096 0.0014899756 1.249535e-06 1.016798e-05 3 197749977 197750074 98 + 1.760 1.638 -0.413
ENSG00000122068 E008 0.1451727 0.0429030134 8.548156e-01   3 197750167 197750346 180 + 0.042 0.000 -8.552
ENSG00000122068 E009 1.8112481 0.0074983019 7.503733e-01 8.370667e-01 3 197750390 197750822 433 + 0.306 0.487 1.015
ENSG00000122068 E010 1.1834019 0.4788780120 4.038579e-01 5.476281e-01 3 197755670 197755834 165 + 0.180 0.503 2.093
ENSG00000122068 E011 118.9724488 0.0074165203 2.629261e-02 6.453650e-02 3 197756426 197756557 132 + 1.866 1.909 0.142
ENSG00000122068 E012 1.1782197 0.0111229177 2.870147e-01 4.274793e-01 3 197763466 197763638 173 + 0.260 0.000 -11.552
ENSG00000122068 E013 138.1640398 0.0002778365 1.251604e-03 4.815152e-03 3 197768439 197768587 149 + 1.931 1.978 0.160
ENSG00000122068 E014 129.7238820 0.0004844874 5.971500e-06 4.179101e-05 3 197770132 197770244 113 + 1.913 1.884 -0.098
ENSG00000122068 E015 117.2983094 0.0018954109 4.565290e-05 2.597395e-04 3 197773403 197773499 97 + 1.869 1.835 -0.116
ENSG00000122068 E016 106.7180048 0.0053176161 1.372911e-03 5.218158e-03 3 197774149 197774210 62 + 1.826 1.808 -0.061
ENSG00000122068 E017 132.3635934 0.0031511284 1.070146e-03 4.201693e-03 3 197776927 197777001 75 + 1.916 1.929 0.042
ENSG00000122068 E018 113.3092028 0.0024326865 2.123718e-03 7.607103e-03 3 197778338 197778379 42 + 1.849 1.866 0.060
ENSG00000122068 E019 140.0032652 0.0002370006 3.939354e-06 2.869718e-05 3 197778380 197778464 85 + 1.944 1.923 -0.070
ENSG00000122068 E020 75.0989698 0.0006385578 2.476856e-05 1.504008e-04 3 197781811 197781814 4 + 1.684 1.594 -0.305
ENSG00000122068 E021 952.4545906 0.0314121021 5.228039e-05 2.931760e-04 3 197781815 197787596 5782 + 2.711 3.089 1.259