ENSG00000122033

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381120 ENSG00000122033 HEK293_OSMI2_2hA HEK293_TMG_2hB MTIF3 protein_coding protein_coding 29.00637 19.33872 38.55295 1.500869 1.135896 0.9949776 20.224354 15.4137060 23.756059 1.0066323 0.7961398 0.6237532 0.7057542 0.79923333 0.61723333 -0.1820 0.000495868 0.000495868 FALSE TRUE
ENST00000405591 ENSG00000122033 HEK293_OSMI2_2hA HEK293_TMG_2hB MTIF3 protein_coding protein_coding 29.00637 19.33872 38.55295 1.500869 1.135896 0.9949776 2.338382 0.2225543 3.508374 0.2225543 1.1699361 3.9192695 0.0738250 0.01056667 0.08946667 0.0789 0.069665624 0.000495868 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122033 E001 6.237550 0.0362947958 6.533799e-01 0.7638736163 13 27435643 27435649 7 - 0.896 0.839 -0.217
ENSG00000122033 E002 17.880604 0.0244732801 5.649326e-01 0.6921525393 13 27435650 27435683 34 - 1.247 1.317 0.246
ENSG00000122033 E003 164.735292 0.0002128399 2.627649e-02 0.0645038339 13 27435684 27435858 175 - 2.191 2.249 0.194
ENSG00000122033 E004 133.909792 0.0002329060 1.136229e-01 0.2108153118 13 27435859 27435893 35 - 2.108 2.153 0.153
ENSG00000122033 E005 83.176161 0.0003126534 7.499923e-02 0.1515317975 13 27437116 27437116 1 - 1.893 1.960 0.223
ENSG00000122033 E006 118.039568 0.0002510837 1.240023e-01 0.2256814274 13 27437117 27437144 28 - 2.051 2.099 0.159
ENSG00000122033 E007 108.972200 0.0003215535 6.831342e-01 0.7864279381 13 27437145 27437149 5 - 2.033 2.044 0.039
ENSG00000122033 E008 198.850687 0.0002132765 5.052411e-01 0.6410497003 13 27437150 27437268 119 - 2.291 2.306 0.048
ENSG00000122033 E009 92.391734 0.0004013817 5.621043e-01 0.6897713267 13 27437269 27437273 5 - 1.976 1.952 -0.080
ENSG00000122033 E010 233.013588 0.0011833009 2.036096e-01 0.3307259482 13 27439989 27440205 217 - 2.381 2.343 -0.126
ENSG00000122033 E011 146.656127 0.0010709926 6.909544e-02 0.1418777469 13 27440206 27440275 70 - 2.193 2.133 -0.200
ENSG00000122033 E012 95.123849 0.0004032813 1.014098e-01 0.1926108820 13 27440276 27440280 5 - 2.007 1.946 -0.206
ENSG00000122033 E013 189.680091 0.0002289046 7.986356e-02 0.1593511223 13 27440281 27440449 169 - 2.298 2.251 -0.154
ENSG00000122033 E014 3.123928 0.0068209450 1.775191e-01 0.2980234715 13 27440450 27440475 26 - 0.696 0.478 -0.985
ENSG00000122033 E015 16.454180 0.0125724997 3.124458e-02 0.0743766501 13 27441017 27441077 61 - 1.319 1.102 -0.768
ENSG00000122033 E016 6.794136 0.0150486346 8.298332e-05 0.0004421578 13 27441078 27441245 168 - 1.064 0.477 -2.403
ENSG00000122033 E017 92.285071 0.0003597648 5.316868e-01 0.6641072084 13 27445088 27445137 50 - 1.957 1.978 0.071
ENSG00000122033 E018 71.000752 0.0004200933 2.780854e-01 0.4177124329 13 27445138 27445156 19 - 1.837 1.880 0.146
ENSG00000122033 E019 4.709664 0.0459375102 1.275889e-01 0.2307916965 13 27449852 27449918 67 - 0.850 0.582 -1.107
ENSG00000122033 E020 3.581592 0.0044252856 9.031170e-01 0.9423744976 13 27449919 27450041 123 - 0.647 0.663 0.070
ENSG00000122033 E021 9.512018 0.0085192932 9.751423e-01 0.9885206249 13 27450064 27450141 78 - 1.011 1.010 -0.001
ENSG00000122033 E022 7.886854 0.0068628843 3.298217e-01 0.4733723969 13 27450142 27450199 58 - 0.881 0.993 0.420
ENSG00000122033 E023 58.934966 0.0005879706 4.901422e-01 0.6274984172 13 27450509 27450591 83 - 1.764 1.794 0.102