ENSG00000122026

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311549 ENSG00000122026 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL21 protein_coding protein_coding 1522.664 1734.181 2054.69 319.5937 40.35758 0.2446651 1371.82653 1614.982008 1812.60360 295.150132 38.430235 0.1665444 0.86145000 0.931833333 0.88230000 -0.04953333 2.448379e-02 4.124374e-06 FALSE  
ENST00000473558 ENSG00000122026 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL21 protein_coding retained_intron 1522.664 1734.181 2054.69 319.5937 40.35758 0.2446651 60.08155 86.363566 54.16819 23.197833 3.310325 -0.6728775 0.06190000 0.048833333 0.02643333 -0.02240000 8.680470e-02 4.124374e-06    
ENST00000493317 ENSG00000122026 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL21 protein_coding protein_coding 1522.664 1734.181 2054.69 319.5937 40.35758 0.2446651 61.72587 8.530342 150.27037 3.107817 32.285807 4.1372190 0.04246667 0.004866667 0.07290000 0.06803333 4.124374e-06 4.124374e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000122026 E001 687.32955 0.0200258457 5.746317e-05 3.188976e-04 13 27251362 27251557 196 + 2.637 2.947 1.032
ENSG00000122026 E002 355.40130 0.0178210231 1.300030e-05 8.407990e-05 13 27251558 27251560 3 + 2.343 2.666 1.077
ENSG00000122026 E003 5547.74021 0.0012268148 9.806868e-01 9.919018e-01 13 27251561 27251578 18 + 3.741 3.743 0.008
ENSG00000122026 E004 5744.01660 0.0013897404 8.210735e-01 8.872090e-01 13 27251579 27251582 4 + 3.759 3.756 -0.010
ENSG00000122026 E005 5984.07125 0.0012152983 9.255510e-01 9.571274e-01 13 27251583 27251585 3 + 3.775 3.775 0.001
ENSG00000122026 E006 35.65562 0.0017127209 6.098608e-03 1.886923e-02 13 27251586 27251596 11 + 1.642 1.499 -0.488
ENSG00000122026 E007 95.79389 0.0107700737 1.113413e-01 2.075190e-01 13 27251597 27251656 60 + 2.039 1.938 -0.339
ENSG00000122026 E008 42.80127 0.0006725279 3.620645e-02 8.397653e-02 13 27251657 27251699 43 + 1.692 1.604 -0.297
ENSG00000122026 E009 35.87507 0.0548234445 4.799608e-01 6.182995e-01 13 27251700 27251850 151 + 1.617 1.512 -0.360
ENSG00000122026 E010 21.11529 0.0038931957 2.690365e-08 3.057661e-07 13 27253705 27253764 60 + 1.530 1.096 -1.518
ENSG00000122026 E011 9775.01477 0.0000773860 1.953171e-03 7.081362e-03 13 27253765 27253843 79 + 3.993 3.993 0.002
ENSG00000122026 E012 10235.91684 0.0002527363 1.570353e-02 4.207249e-02 13 27254220 27254281 62 + 4.014 4.007 -0.023
ENSG00000122026 E013 53.15707 0.0126372122 2.235419e-10 3.711274e-09 13 27254282 27254467 186 + 1.932 1.458 -1.611
ENSG00000122026 E014 36.39045 0.0005602886 9.667286e-10 1.437324e-08 13 27254944 27255063 120 + 1.728 1.396 -1.134
ENSG00000122026 E015 56.13361 0.0004080550 1.895778e-06 1.482585e-05 13 27255064 27255241 178 + 1.860 1.662 -0.668
ENSG00000122026 E016 12175.09309 0.0003617553 1.264460e-01 2.292019e-01 13 27255242 27255349 108 + 4.085 4.085 -0.001
ENSG00000122026 E017 6812.70487 0.0005853619 9.080794e-01 9.456462e-01 13 27255350 27255354 5 + 3.825 3.839 0.045
ENSG00000122026 E018 27.29657 0.0066481850 3.581761e-07 3.261651e-06 13 27255355 27255400 46 + 1.622 1.251 -1.282
ENSG00000122026 E019 69.20710 0.0259774899 3.975930e-05 2.292802e-04 13 27255401 27255856 456 + 2.012 1.638 -1.261
ENSG00000122026 E020 9367.84156 0.0009661850 3.709841e-01 5.153950e-01 13 27256184 27256334 151 + 3.956 3.981 0.085
ENSG00000122026 E021 2930.00934 0.0035628105 6.729816e-03 2.052091e-02 13 27256436 27256691 256 + 3.410 3.505 0.313