ENSG00000121957

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264126 ENSG00000121957 HEK293_OSMI2_2hA HEK293_TMG_2hB GPSM2 protein_coding protein_coding 7.448472 2.549784 11.84165 0.0971267 0.0820014 2.210994 0.7713702 0.27695355 1.4279575 0.06501118 0.4563383 2.325132 0.09120000 0.11020000 0.1210333 0.01083333 9.835264e-01 2.257501e-09 FALSE TRUE
ENST00000435987 ENSG00000121957 HEK293_OSMI2_2hA HEK293_TMG_2hB GPSM2 protein_coding protein_coding 7.448472 2.549784 11.84165 0.0971267 0.0820014 2.210994 0.6202249 0.00000000 1.8266431 0.00000000 0.1865042 7.520928 0.05836667 0.00000000 0.1543000 0.15430000 2.257501e-09 2.257501e-09 FALSE FALSE
ENST00000441735 ENSG00000121957 HEK293_OSMI2_2hA HEK293_TMG_2hB GPSM2 protein_coding protein_coding 7.448472 2.549784 11.84165 0.0971267 0.0820014 2.210994 2.1608062 0.84728562 2.9444662 0.12825884 0.3481728 1.785050 0.27573750 0.32950000 0.2483667 -0.08113333 4.531975e-01 2.257501e-09 FALSE TRUE
ENST00000642355 ENSG00000121957 HEK293_OSMI2_2hA HEK293_TMG_2hB GPSM2 protein_coding protein_coding 7.448472 2.549784 11.84165 0.0971267 0.0820014 2.210994 0.6170329 0.03461483 0.6962919 0.03461483 0.3607236 3.984669 0.08746667 0.01296667 0.0584000 0.04543333 7.163819e-01 2.257501e-09 FALSE TRUE
ENST00000676404 ENSG00000121957 HEK293_OSMI2_2hA HEK293_TMG_2hB GPSM2 protein_coding nonsense_mediated_decay 7.448472 2.549784 11.84165 0.0971267 0.0820014 2.210994 0.2318149 0.00000000 0.6316452 0.00000000 0.3469288 6.003704 0.02289583 0.00000000 0.0536000 0.05360000 7.630632e-02 2.257501e-09 TRUE TRUE
MSTRG.1743.14 ENSG00000121957 HEK293_OSMI2_2hA HEK293_TMG_2hB GPSM2 protein_coding   7.448472 2.549784 11.84165 0.0971267 0.0820014 2.210994 2.3216054 1.22214156 3.2058591 0.08327947 0.3388996 1.384036 0.32706250 0.48323333 0.2707333 -0.21250000 1.745681e-02 2.257501e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121957 E001 0.0000000       1 108875350 108875382 33 +      
ENSG00000121957 E002 0.0000000       1 108876737 108876959 223 +      
ENSG00000121957 E003 0.1472490 0.0437616680 1.000000e+00   1 108876960 108876978 19 + 0.069 0.000 -9.611
ENSG00000121957 E004 0.1472490 0.0437616680 1.000000e+00   1 108876979 108876980 2 + 0.069 0.000 -10.805
ENSG00000121957 E005 0.1472490 0.0437616680 1.000000e+00   1 108876981 108876981 1 + 0.069 0.000 -10.805
ENSG00000121957 E006 0.1472490 0.0437616680 1.000000e+00   1 108876982 108876984 3 + 0.069 0.000 -10.805
ENSG00000121957 E007 0.2924217 0.0272619680 1.000000e+00   1 108876985 108876987 3 + 0.128 0.000 -11.770
ENSG00000121957 E008 0.2924217 0.0272619680 1.000000e+00   1 108876988 108876992 5 + 0.128 0.000 -11.770
ENSG00000121957 E009 1.4769841 0.0089408326 5.553880e-02 1.189022e-01 1 108876993 108877002 10 + 0.433 0.000 -13.972
ENSG00000121957 E010 9.4897337 0.0023272843 1.002460e-03 3.966854e-03 1 108877003 108877112 110 + 1.045 0.541 -2.024
ENSG00000121957 E011 7.3504732 0.0022096391 4.464808e-02 9.955444e-02 1 108877113 108877134 22 + 0.922 0.613 -1.245
ENSG00000121957 E012 7.7149156 0.0022613394 2.796480e-02 6.794550e-02 1 108877135 108877145 11 + 0.947 0.613 -1.343
ENSG00000121957 E013 7.8790147 0.0021153736 1.398309e-01 2.477929e-01 1 108877146 108877158 13 + 0.939 0.727 -0.826
ENSG00000121957 E014 15.9052690 0.0010926736 3.312409e-04 1.505761e-03 1 108877159 108877228 70 + 1.245 0.818 -1.572
ENSG00000121957 E015 0.1472490 0.0437616680 1.000000e+00   1 108877256 108877530 275 + 0.069 0.000 -10.805
ENSG00000121957 E016 2.7462381 0.0056971539 6.099437e-02 1.283070e-01 1 108877531 108877774 244 + 0.592 0.210 -2.229
ENSG00000121957 E017 0.5954526 0.0184057593 3.684206e-01 5.128339e-01 1 108882476 108882579 104 + 0.226 0.000 -12.730
ENSG00000121957 E018 1.4049754 0.0610295878 9.477109e-01 9.711113e-01 1 108882580 108882625 46 + 0.342 0.350 0.052
ENSG00000121957 E019 0.2966881 0.0270790860 1.000000e+00   1 108884821 108885274 454 + 0.128 0.000 -11.770
ENSG00000121957 E020 24.9528657 0.0007748085 4.620498e-01 6.019513e-01 1 108885275 108885474 200 + 1.369 1.306 -0.221
ENSG00000121957 E021 15.0487721 0.0050064878 7.807172e-01 8.591071e-01 1 108885475 108885506 32 + 1.140 1.165 0.089
ENSG00000121957 E022 22.2886912 0.0042509842 8.565086e-01 9.112673e-01 1 108885507 108885578 72 + 1.312 1.292 -0.068
ENSG00000121957 E023 0.0000000       1 108886079 108886172 94 +      
ENSG00000121957 E024 0.1515154 0.0433417618 1.000000e+00   1 108889620 108891064 1445 + 0.069 0.000 -10.805
ENSG00000121957 E025 66.1797646 0.0004220291 5.582182e-02 1.193827e-01 1 108896864 108897085 222 + 1.790 1.688 -0.347
ENSG00000121957 E026 0.0000000       1 108897086 108897086 1 +      
ENSG00000121957 E027 40.2572672 0.0005164343 5.237464e-02 1.133903e-01 1 108897492 108897535 44 + 1.585 1.451 -0.457
ENSG00000121957 E028 58.3715741 0.0004193264 4.358896e-02 9.762491e-02 1 108897536 108897627 92 + 1.738 1.622 -0.392
ENSG00000121957 E029 63.9366445 0.0019504053 4.288997e-02 9.633862e-02 1 108897959 108898101 143 + 1.777 1.659 -0.397
ENSG00000121957 E030 41.8258723 0.0035100432 1.831047e-01 3.050881e-01 1 108898642 108898765 124 + 1.592 1.496 -0.328
ENSG00000121957 E031 31.3276449 0.0007194480 5.345307e-01 6.665727e-01 1 108898879 108898994 116 + 1.460 1.411 -0.168
ENSG00000121957 E032 49.3896707 0.0004989359 3.925373e-01 5.365016e-01 1 108901790 108901903 114 + 1.656 1.602 -0.181
ENSG00000121957 E033 35.6713332 0.0005879048 7.979393e-01 8.710799e-01 1 108901904 108901945 42 + 1.500 1.513 0.047
ENSG00000121957 E034 0.1515154 0.0433417618 1.000000e+00   1 108901946 108903125 1180 + 0.069 0.000 -10.805
ENSG00000121957 E035 43.3688224 0.0005114519 8.452078e-02 1.666289e-01 1 108903126 108903169 44 + 1.561 1.659 0.335
ENSG00000121957 E036 44.7836920 0.0005575383 4.192733e-01 5.625160e-01 1 108903170 108903234 65 + 1.590 1.635 0.151
ENSG00000121957 E037 0.1515154 0.0433417618 1.000000e+00   1 108903235 108903287 53 + 0.069 0.000 -10.805
ENSG00000121957 E038 1.2543784 0.1511464661 5.982552e-01 7.198876e-01 1 108903288 108904124 837 + 0.342 0.211 -0.933
ENSG00000121957 E039 56.2204568 0.0034322078 1.613143e-01 2.768038e-01 1 108904125 108904254 130 + 1.676 1.754 0.263
ENSG00000121957 E040 1.5531549 0.0084005216 5.345541e-01 6.665904e-01 1 108904255 108909613 5359 + 0.342 0.456 0.636
ENSG00000121957 E041 0.0000000       1 108909614 108909981 368 +      
ENSG00000121957 E042 48.0472140 0.0036330272 4.186237e-01 5.618672e-01 1 108914338 108914408 71 + 1.618 1.665 0.160
ENSG00000121957 E043 1.9293523 0.0084295715 5.795483e-01 7.044444e-01 1 108914628 108915188 561 + 0.459 0.350 -0.603
ENSG00000121957 E044 78.0607560 0.0050764492 9.365466e-01 9.640982e-01 1 108918613 108918789 177 + 1.836 1.836 -0.001
ENSG00000121957 E045 0.4439371 0.0215671895 5.479619e-01 6.778975e-01 1 108918790 108919150 361 + 0.180 0.000 -12.333
ENSG00000121957 E046 70.4660358 0.0020753209 3.285825e-01 4.720895e-01 1 108922417 108922576 160 + 1.781 1.828 0.157
ENSG00000121957 E047 88.7126084 0.0003684346 1.578349e-03 5.888641e-03 1 108924000 108924214 215 + 1.856 1.981 0.422
ENSG00000121957 E048 6.8330075 0.0186447521 6.553939e-06 4.542915e-05 1 108924215 108924361 147 + 0.610 1.199 2.267
ENSG00000121957 E049 0.5181333 0.0206396873 6.161278e-01 7.342351e-01 1 108926275 108926890 616 + 0.128 0.210 0.861
ENSG00000121957 E050 74.4408233 0.0021330931 5.975056e-03 1.854238e-02 1 108929701 108929975 275 + 1.779 1.908 0.435
ENSG00000121957 E051 81.4470711 0.0004708555 7.226607e-04 2.979973e-03 1 108929976 108931312 1337 + 1.815 1.955 0.474
ENSG00000121957 E052 70.0638200 0.0156817617 1.312458e-01 2.358872e-01 1 108931313 108934545 3233 + 1.817 1.691 -0.426