ENSG00000121892

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303538 ENSG00000121892 HEK293_OSMI2_2hA HEK293_TMG_2hB PDS5A protein_coding protein_coding 16.65847 4.111629 30.50111 0.1371837 0.9684636 2.888048 8.309208 3.800568 14.90272 0.1773103 0.5357366 1.968466 0.6669333 0.9235667 0.4888000 -0.4347667 7.482200e-26 5.472334e-41 FALSE TRUE
MSTRG.24762.2 ENSG00000121892 HEK293_OSMI2_2hA HEK293_TMG_2hB PDS5A protein_coding   16.65847 4.111629 30.50111 0.1371837 0.9684636 2.888048 7.278691 0.000000 13.28366 0.0000000 0.2742127 10.376523 0.2600542 0.0000000 0.4360333 0.4360333 5.472334e-41 5.472334e-41 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121892 E001 564.6688290 0.0162393866 2.989120e-15 1.064036e-13 4 39822863 39825020 2158 - 2.469 2.995 1.749
ENSG00000121892 E002 120.2460622 0.0003021100 8.047638e-06 5.460605e-05 4 39825021 39825178 158 - 1.874 2.136 0.878
ENSG00000121892 E003 207.6340781 0.0017483902 1.595292e-01 2.744914e-01 4 39825179 39825488 310 - 2.135 2.269 0.446
ENSG00000121892 E004 4.9987883 0.0196775644 1.568016e-02 4.202294e-02 4 39837012 39837855 844 - 0.555 0.999 1.792
ENSG00000121892 E005 209.5511680 0.0001995269 5.403628e-01 6.715206e-01 4 39837856 39838208 353 - 2.144 2.244 0.333
ENSG00000121892 E006 124.5077015 0.0003216657 3.628498e-01 5.072638e-01 4 39841948 39842056 109 - 1.933 1.971 0.126
ENSG00000121892 E007 137.8236049 0.0002636933 2.510507e-01 3.871926e-01 4 39844656 39844801 146 - 1.978 2.007 0.098
ENSG00000121892 E008 88.9324137 0.0044500487 8.941385e-01 9.363218e-01 4 39845818 39845880 63 - 1.783 1.852 0.232
ENSG00000121892 E009 3.2495224 0.0143869517 9.982587e-01 1.000000e+00 4 39845881 39848561 2681 - 0.511 0.567 0.263
ENSG00000121892 E010 116.1305184 0.0017282833 8.849979e-01 9.304896e-01 4 39848851 39848970 120 - 1.896 1.967 0.237
ENSG00000121892 E011 150.0921410 0.0037844844 6.180939e-02 1.296687e-01 4 39849520 39849652 133 - 2.019 2.001 -0.060
ENSG00000121892 E012 128.2991454 0.0002344484 1.041410e-01 1.968039e-01 4 39862219 39862333 115 - 1.949 1.954 0.018
ENSG00000121892 E013 102.1934503 0.0002811725 4.361978e-02 9.768238e-02 4 39862869 39862985 117 - 1.854 1.829 -0.085
ENSG00000121892 E014 81.3749524 0.0003074343 1.196453e-01 2.194620e-01 4 39862986 39863073 88 - 1.757 1.747 -0.035
ENSG00000121892 E015 91.5217276 0.0013012660 3.407776e-03 1.146023e-02 4 39863336 39863459 124 - 1.818 1.725 -0.313
ENSG00000121892 E016 121.2435537 0.0002587572 1.861115e-03 6.792582e-03 4 39866861 39866997 137 - 1.935 1.863 -0.242
ENSG00000121892 E017 0.0000000       4 39866998 39867015 18 -      
ENSG00000121892 E018 0.0000000       4 39868670 39868735 66 -      
ENSG00000121892 E019 99.3322843 0.0002868789 4.415858e-03 1.430770e-02 4 39869394 39869462 69 - 1.848 1.774 -0.250
ENSG00000121892 E020 0.0000000       4 39872792 39872985 194 -      
ENSG00000121892 E021 132.0224179 0.0003083135 1.687550e-04 8.298721e-04 4 39872986 39873144 159 - 1.973 1.873 -0.335
ENSG00000121892 E022 124.4682395 0.0002540984 5.160142e-05 2.897201e-04 4 39874289 39874412 124 - 1.950 1.829 -0.406
ENSG00000121892 E023 129.6054138 0.0002550930 2.252397e-06 1.732199e-05 4 39876993 39877153 161 - 1.971 1.817 -0.517
ENSG00000121892 E024 118.4361617 0.0002811846 4.041542e-05 2.326733e-04 4 39879728 39879833 106 - 1.929 1.799 -0.437
ENSG00000121892 E025 125.5023227 0.0003554414 3.637365e-07 3.307516e-06 4 39890249 39890364 116 - 1.961 1.780 -0.607
ENSG00000121892 E026 17.2053300 0.0088964892 1.363516e-03 5.187967e-03 4 39898014 39898388 375 - 1.028 1.431 1.427
ENSG00000121892 E027 136.8187021 0.0018129915 4.885251e-04 2.116194e-03 4 39898389 39898528 140 - 1.990 1.894 -0.323
ENSG00000121892 E028 89.9563799 0.0003049306 1.887003e-02 4.904877e-02 4 39898777 39898825 49 - 1.805 1.753 -0.174
ENSG00000121892 E029 75.5035419 0.0004163550 3.213840e-02 7.612619e-02 4 39900426 39900454 29 - 1.730 1.679 -0.174
ENSG00000121892 E030 88.7690392 0.0003015498 5.857480e-01 7.093883e-01 4 39900455 39900507 53 - 1.785 1.835 0.167
ENSG00000121892 E031 100.2233400 0.0004345079 7.615201e-01 8.453714e-01 4 39902347 39902460 114 - 1.835 1.898 0.213
ENSG00000121892 E032 44.3304642 0.0051713081 2.375409e-01 3.713008e-01 4 39904040 39904041 2 - 1.470 1.637 0.569
ENSG00000121892 E033 125.1054928 0.0037244643 9.310130e-01 9.605682e-01 4 39904042 39904191 150 - 1.928 2.001 0.246
ENSG00000121892 E034 136.1157775 0.0005303713 2.899061e-02 6.998642e-02 4 39908395 39908540 146 - 1.978 1.958 -0.066
ENSG00000121892 E035 0.0000000       4 39908541 39908884 344 -      
ENSG00000121892 E036 0.1515154 0.0421188060 8.774727e-01   4 39910065 39910243 179 - 0.048 0.000 -7.524
ENSG00000121892 E037 118.8532673 0.0002627422 8.556394e-05 4.543114e-04 4 39910244 39910338 95 - 1.930 1.812 -0.400
ENSG00000121892 E038 117.2525880 0.0004586019 4.173384e-04 1.840827e-03 4 39913611 39913726 116 - 1.923 1.823 -0.336
ENSG00000121892 E039 104.7571559 0.0003040190 1.746345e-02 4.596275e-02 4 39917048 39917188 141 - 1.867 1.823 -0.147
ENSG00000121892 E040 94.2969907 0.0005721968 2.114821e-06 1.636294e-05 4 39920319 39920399 81 - 1.841 1.636 -0.693
ENSG00000121892 E041 106.7394492 0.0071085483 2.487396e-04 1.169827e-03 4 39922622 39922748 127 - 1.892 1.718 -0.587
ENSG00000121892 E042 75.0315314 0.0031925128 1.701074e-03 6.286962e-03 4 39925836 39925933 98 - 1.738 1.598 -0.474
ENSG00000121892 E043 54.4096753 0.0007154147 2.782633e-02 6.767244e-02 4 39926775 39926861 87 - 1.593 1.511 -0.280
ENSG00000121892 E044 139.6125948 0.0002279013 1.069301e-02 3.043691e-02 4 39927961 39928164 204 - 1.992 1.958 -0.113
ENSG00000121892 E045 0.2924217 0.0290785164 1.000000e+00   4 39976113 39976439 327 - 0.092 0.000 -8.523
ENSG00000121892 E046 111.6976559 0.0011157869 9.954928e-01 1.000000e+00 4 39976440 39976617 178 - 1.879 1.958 0.265
ENSG00000121892 E047 0.7675920 0.0161941281 1.466446e-01 2.571235e-01 4 39977248 39977252 5 - 0.132 0.446 2.344
ENSG00000121892 E048 1.6533899 0.0091372957 6.736986e-01 7.793163e-01 4 39977253 39977456 204 - 0.314 0.446 0.759
ENSG00000121892 E049 62.1278455 0.0121497910 2.121808e-01 3.411007e-01 4 39977457 39977956 500 - 1.645 1.617 -0.097