ENSG00000121879

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263967 ENSG00000121879 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3CA protein_coding protein_coding 1.286773 0.2520994 2.024449 0.03117555 0.190874 2.956452 1.05002703 0.10513050 1.73595991 0.053869387 0.052087550 3.9226785 0.61844583 0.4764667 0.87223333 0.39576667 0.24308445 0.03136606 FALSE TRUE
ENST00000477735 ENSG00000121879 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3CA protein_coding protein_coding 1.286773 0.2520994 2.024449 0.03117555 0.190874 2.956452 0.07982508 0.00000000 0.20127906 0.000000000 0.201279059 4.4010779 0.02693333 0.0000000 0.08423333 0.08423333 1.00000000 0.03136606 FALSE FALSE
ENST00000643187 ENSG00000121879 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3CA protein_coding protein_coding 1.286773 0.2520994 2.024449 0.03117555 0.190874 2.956452 0.04937796 0.01117708 0.03697287 0.011177082 0.018487991 1.1493238 0.06664167 0.0501000 0.01726667 -0.03283333 0.77074033 0.03136606 FALSE TRUE
ENST00000675467 ENSG00000121879 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3CA protein_coding retained_intron 1.286773 0.2520994 2.024449 0.03117555 0.190874 2.956452 0.02973374 0.02618015 0.01455166 0.005617875 0.005105389 -0.5593778 0.07738750 0.1065333 0.00770000 -0.09883333 0.03136606 0.03136606 FALSE TRUE
ENST00000675786 ENSG00000121879 HEK293_OSMI2_2hA HEK293_TMG_2hB PIK3CA protein_coding nonsense_mediated_decay 1.286773 0.2520994 2.024449 0.03117555 0.190874 2.956452 0.04988280 0.09611013 0.00000000 0.096110132 0.000000000 -3.4074905 0.15079167 0.3057000 0.00000000 -0.30570000 0.50767849 0.03136606 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121879 E001 0.1451727 0.0429191807 7.880361e-01   3 179148114 179148219 106 + 0.050 0.000 -7.039
ENSG00000121879 E002 2.4046243 0.0078164869 9.970415e-01 1.0000000000 3 179148357 179148573 217 + 0.435 0.434 -0.007
ENSG00000121879 E003 1.2178718 0.0105833955 3.413497e-01 0.4852520346 3 179148574 179148603 30 + 0.240 0.434 1.216
ENSG00000121879 E004 0.0000000       3 179149001 179149126 126 +      
ENSG00000121879 E005 0.0000000       3 179149527 179149716 190 +      
ENSG00000121879 E006 0.1472490 0.0432572706 7.889765e-01   3 179196019 179198749 2731 + 0.050 0.000 -9.056
ENSG00000121879 E007 18.2920096 0.0010127909 2.239554e-01 0.3551380160 3 179198750 179199177 428 + 1.163 1.019 -0.520
ENSG00000121879 E008 0.0000000       3 179199178 179199179 2 +      
ENSG00000121879 E009 13.2313517 0.0014357335 3.210902e-01 0.4642948343 3 179199690 179199899 210 + 1.031 0.896 -0.502
ENSG00000121879 E010 18.2840685 0.0010059362 3.782610e-01 0.5225347838 3 179201290 179201540 251 + 1.156 1.054 -0.368
ENSG00000121879 E011 0.4502799 0.0251594180 1.000000e+00 1.0000000000 3 179202977 179203543 567 + 0.137 0.000 -10.572
ENSG00000121879 E012 16.4674993 0.0011032423 1.276752e-02 0.0353678120 3 179203544 179203789 246 + 1.137 0.789 -1.300
ENSG00000121879 E013 10.1977525 0.0019206867 2.091478e-02 0.0534110191 3 179204503 179204588 86 + 0.955 0.554 -1.636
ENSG00000121879 E014 11.4145801 0.0018699268 3.172465e-02 0.0753141017 3 179209595 179209700 106 + 0.994 0.647 -1.368
ENSG00000121879 E015 14.6103265 0.0275430215 7.610463e-01 0.8449840897 3 179210186 179210338 153 + 1.064 1.018 -0.168
ENSG00000121879 E016 0.0000000       3 179210412 179210430 19 +      
ENSG00000121879 E017 11.6820599 0.0015604510 5.272904e-01 0.6604011783 3 179210431 179210523 93 + 0.984 0.896 -0.328
ENSG00000121879 E018 11.5581160 0.0040058087 6.173700e-01 0.7352067647 3 179210524 179210565 42 + 0.955 1.019 0.238
ENSG00000121879 E019 0.1515154 0.0421701337 7.871459e-01   3 179218209 179218209 1 + 0.050 0.000 -9.061
ENSG00000121879 E020 15.9191465 0.0020165840 3.907550e-01 0.5347136133 3 179218210 179218334 125 + 1.074 1.169 0.342
ENSG00000121879 E021 0.0000000       3 179218335 179219195 861 +      
ENSG00000121879 E022 10.7096038 0.0017036687 4.353084e-01 0.5775505402 3 179219196 179219277 82 + 0.918 1.019 0.378
ENSG00000121879 E023 0.0000000       3 179219278 179219570 293 +      
ENSG00000121879 E024 13.8641908 0.0014022282 8.522715e-01 0.9084377841 3 179219571 179219735 165 + 1.031 1.054 0.083
ENSG00000121879 E025 12.1297859 0.0017841580 1.427333e-01 0.2517470294 3 179219949 179220052 104 + 1.005 0.789 -0.823
ENSG00000121879 E026 19.4334424 0.0019759654 1.512222e-01 0.2633402021 3 179220986 179221157 172 + 1.188 1.019 -0.609
ENSG00000121879 E027 17.1414093 0.0012689341 7.854151e-01 0.8624670240 3 179224081 179224187 107 + 1.117 1.086 -0.112
ENSG00000121879 E028 17.8720448 0.0107969802 6.856856e-01 0.7883590805 3 179224700 179224821 122 + 1.137 1.087 -0.180
ENSG00000121879 E029 15.4985450 0.0016764692 5.912525e-02 0.1251365976 3 179225962 179226040 79 + 1.104 0.846 -0.961
ENSG00000121879 E030 0.1472490 0.0432572706 7.889765e-01   3 179226882 179229271 2390 + 0.050 0.000 -9.056
ENSG00000121879 E031 19.5544553 0.0010374994 2.524986e-01 0.3888590355 3 179229272 179229442 171 + 1.185 1.054 -0.471
ENSG00000121879 E032 0.1515154 0.0421701337 7.871459e-01   3 179229443 179230003 561 + 0.050 0.000 -9.061
ENSG00000121879 E033 15.9144886 0.0262494818 3.542476e-01 0.4985265077 3 179230004 179230121 118 + 1.073 1.191 0.422
ENSG00000121879 E034 19.5637069 0.0016468807 5.628918e-03 0.0176284724 3 179230225 179230376 152 + 1.125 1.384 0.912
ENSG00000121879 E035 0.6299079 0.0194297277 4.732731e-01 0.6122559929 3 179233289 179233371 83 + 0.137 0.269 1.217
ENSG00000121879 E036 86.1329320 0.0004495376 2.743493e-05 0.0001647009 3 179234094 179240093 6000 + 1.760 1.943 0.617