ENSG00000121741

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382871 ENSG00000121741 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM2 protein_coding protein_coding 9.314604 1.81976 16.85484 0.5194302 0.4548709 3.204292 1.24281556 0.12464855 2.7022616 0.12464855 0.5148101 4.3322258 0.10357083 0.12433333 0.16016667 0.03583333 4.674182e-01 2.052779e-07 FALSE TRUE
ENST00000382881 ENSG00000121741 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM2 protein_coding retained_intron 9.314604 1.81976 16.85484 0.5194302 0.4548709 3.204292 1.76850160 0.08974447 3.1259331 0.08974447 0.2999953 4.9745141 0.12822500 0.03223333 0.18480000 0.15256667 3.045997e-02 2.052779e-07 FALSE TRUE
ENST00000494061 ENSG00000121741 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM2 protein_coding retained_intron 9.314604 1.81976 16.85484 0.5194302 0.4548709 3.204292 3.07839937 0.79569243 5.2516651 0.45698350 0.3528381 2.7072183 0.38209167 0.34973333 0.31130000 -0.03843333 1.000000e+00 2.052779e-07   FALSE
ENST00000610343 ENSG00000121741 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM2 protein_coding protein_coding 9.314604 1.81976 16.85484 0.5194302 0.4548709 3.204292 0.96609235 0.23173298 1.1720845 0.11898667 0.6324039 2.2898470 0.10950000 0.10713333 0.06860000 -0.03853333 8.922678e-01 2.052779e-07 FALSE TRUE
ENST00000620447 ENSG00000121741 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM2 protein_coding protein_coding 9.314604 1.81976 16.85484 0.5194302 0.4548709 3.204292 1.05595098 0.00000000 2.2143467 0.00000000 0.1564744 7.7972378 0.07213333 0.00000000 0.13106667 0.13106667 2.052779e-07 2.052779e-07 FALSE TRUE
MSTRG.8393.1 ENSG00000121741 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM2 protein_coding   9.314604 1.81976 16.85484 0.5194302 0.4548709 3.204292 0.05289908 0.18140054 0.0000000 0.18140054 0.0000000 -4.2585230 0.03648750 0.18096667 0.00000000 -0.18096667 4.874586e-01 2.052779e-07 FALSE TRUE
MSTRG.8393.10 ENSG00000121741 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM2 protein_coding   9.314604 1.81976 16.85484 0.5194302 0.4548709 3.204292 0.35194576 0.23829309 0.4007246 0.14002788 0.2191269 0.7261271 0.06840833 0.10390000 0.02346667 -0.08043333 5.831208e-01 2.052779e-07 FALSE TRUE
MSTRG.8393.9 ENSG00000121741 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM2 protein_coding   9.314604 1.81976 16.85484 0.5194302 0.4548709 3.204292 0.09776494 0.10017812 0.0000000 0.10017812 0.0000000 -3.4617659 0.02060417 0.05986667 0.00000000 -0.05986667 3.486639e-01 2.052779e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121741 E001 0.1451727 0.0431172898 8.699478e-01   13 19958677 19958707 31 + 0.050 0.000 -8.279
ENSG00000121741 E002 0.4482035 0.0263327182 1.000000e+00 1.000000e+00 13 19958708 19958726 19 + 0.136 0.000 -10.958
ENSG00000121741 E003 1.0436561 0.0152611643 3.386302e-01 4.825067e-01 13 19958727 19958744 18 + 0.269 0.000 -12.110
ENSG00000121741 E004 2.5354020 0.0383872067 5.887466e-02 1.247038e-01 13 19958745 19958771 27 + 0.490 0.000 -13.357
ENSG00000121741 E005 2.5396684 0.0751301564 7.030537e-02 1.438632e-01 13 19958772 19958782 11 + 0.490 0.000 -13.401
ENSG00000121741 E006 9.6632380 0.0934299416 1.970345e-01 3.225097e-01 13 19958783 19958838 56 + 0.924 0.648 -1.103
ENSG00000121741 E007 8.9109569 0.0974318490 6.854767e-01 7.881984e-01 13 19958839 19958841 3 + 0.870 0.795 -0.294
ENSG00000121741 E008 2.0724472 0.0084233879 3.579350e-01 5.023463e-01 13 19958842 19958904 63 + 0.348 0.556 1.081
ENSG00000121741 E009 2.5016226 0.0235726070 5.672463e-01 6.940774e-01 13 19958905 19958959 55 + 0.414 0.556 0.705
ENSG00000121741 E010 4.1454250 0.0614065322 1.081256e-01 2.027624e-01 13 19958960 19959135 176 + 0.634 0.271 -1.933
ENSG00000121741 E011 1.0329332 0.1644715731 4.053435e-01 5.490334e-01 13 19959859 19959957 99 + 0.269 0.000 -12.236
ENSG00000121741 E012 26.4857836 0.0007566518 7.746256e-02 1.553885e-01 13 19959958 19960026 69 + 1.309 1.171 -0.486
ENSG00000121741 E013 1.3487633 0.1210757565 2.698336e-01 4.083881e-01 13 19965220 19965281 62 + 0.324 0.000 -12.579
ENSG00000121741 E014 8.6488865 0.0019127183 2.661362e-01 4.042859e-01 13 19970025 19970071 47 + 0.868 0.726 -0.561
ENSG00000121741 E015 110.7591602 0.0002852688 4.220297e-06 3.052779e-05 13 19993063 19993564 502 + 1.922 1.723 -0.670
ENSG00000121741 E016 26.0689685 0.0025380282 2.774937e-02 6.751648e-02 13 19993565 19993825 261 + 1.312 1.117 -0.689
ENSG00000121741 E017 45.3422470 0.0004707283 6.313777e-02 1.319354e-01 13 19993826 19993919 94 + 1.531 1.430 -0.347
ENSG00000121741 E018 73.7824127 0.0006064051 1.344171e-02 3.694477e-02 13 20002850 20003135 286 + 1.738 1.628 -0.372
ENSG00000121741 E019 45.9828553 0.0004598551 6.638178e-03 2.028490e-02 13 20005074 20005239 166 + 1.545 1.370 -0.601
ENSG00000121741 E020 61.3590711 0.0004349180 1.424561e-01 2.513775e-01 13 20006374 20006586 213 + 1.653 1.601 -0.179
ENSG00000121741 E021 39.6188019 0.0005570298 7.679686e-02 1.543654e-01 13 20019547 20019618 72 + 1.474 1.370 -0.359
ENSG00000121741 E022 1.6984293 0.0081617012 6.550933e-01 7.650535e-01 13 20019619 20019963 345 + 0.347 0.271 -0.504
ENSG00000121741 E023 3.4709676 0.0070221292 6.100567e-01 7.294348e-01 13 20024394 20025306 913 + 0.522 0.649 0.568
ENSG00000121741 E024 1.4727177 0.0088680088 1.814354e-01 3.030460e-01 13 20025307 20025375 69 + 0.347 0.000 -12.580
ENSG00000121741 E025 5.2812864 0.0094818364 3.726921e-01 5.171155e-01 13 20025376 20026518 1143 + 0.692 0.555 -0.597
ENSG00000121741 E026 1.2274368 0.0166791821 9.621653e-01 9.801334e-01 13 20026519 20026611 93 + 0.269 0.270 0.010
ENSG00000121741 E027 61.3229091 0.0024594553 8.109137e-05 4.331496e-04 13 20026612 20026762 151 + 1.676 1.416 -0.891
ENSG00000121741 E028 60.8133279 0.0009274162 1.543443e-03 5.776612e-03 13 20027203 20027318 116 + 1.665 1.483 -0.623
ENSG00000121741 E029 0.5202097 0.0206633617 3.507342e-01 4.949167e-01 13 20027985 20028064 80 + 0.095 0.271 1.819
ENSG00000121741 E030 50.1998414 0.0004883453 5.400056e-01 6.712053e-01 13 20031319 20031435 117 + 1.561 1.561 0.000
ENSG00000121741 E031 0.1482932 0.0416863838 5.616362e-02   13 20031436 20031439 4 + 0.000 0.270 13.826
ENSG00000121741 E032 47.4656929 0.0037144967 3.876173e-01 5.317546e-01 13 20034254 20034404 151 + 1.523 1.628 0.356
ENSG00000121741 E033 61.2220811 0.0026495229 2.707643e-01 4.094136e-01 13 20036737 20036909 173 + 1.652 1.619 -0.112
ENSG00000121741 E034 0.1817044 0.0403872426 5.577996e-02   13 20036910 20036913 4 + 0.000 0.271 13.839
ENSG00000121741 E035 25.5604457 0.0063427330 1.894291e-01 3.130252e-01 13 20051433 20051440 8 + 1.295 1.195 -0.353
ENSG00000121741 E036 64.5734352 0.0020688839 1.565738e-01 2.705391e-01 13 20051441 20051598 158 + 1.678 1.628 -0.173
ENSG00000121741 E037 42.5707036 0.0005384104 9.021084e-02 1.754476e-01 13 20052277 20052311 35 + 1.507 1.416 -0.314
ENSG00000121741 E038 67.2874666 0.0008688911 2.961440e-02 7.120196e-02 13 20058575 20058704 130 + 1.698 1.601 -0.331
ENSG00000121741 E039 64.0329322 0.0040888115 7.766436e-02 1.557109e-01 13 20059447 20059562 116 + 1.675 1.592 -0.282
ENSG00000121741 E040 77.6751460 0.0003661849 6.102890e-01 7.296224e-01 13 20061053 20061224 172 + 1.743 1.757 0.049
ENSG00000121741 E041 53.8059814 0.0005451534 6.912037e-01 7.927262e-01 13 20062846 20062971 126 + 1.577 1.646 0.233
ENSG00000121741 E042 49.7708176 0.0012084620 2.259127e-01 3.574853e-01 13 20064451 20064545 95 + 1.539 1.662 0.420
ENSG00000121741 E043 0.3686942 0.0297326614 1.807116e-01 3.020803e-01 13 20066578 20066850 273 + 0.050 0.271 2.820
ENSG00000121741 E044 60.5347474 0.0036692987 4.205013e-01 5.637078e-01 13 20066851 20066978 128 + 1.626 1.723 0.328
ENSG00000121741 E045 35.4798251 0.0041413914 4.980236e-01 6.345347e-01 13 20066979 20067019 41 + 1.419 1.401 -0.061
ENSG00000121741 E046 72.9452153 0.0003851040 7.905317e-01 8.660101e-01 13 20067239 20067390 152 + 1.716 1.744 0.094
ENSG00000121741 E047 0.2214452 0.0380599769 5.562499e-02   13 20068089 20068349 261 + 0.000 0.271 13.857
ENSG00000121741 E048 69.0741676 0.0004231620 2.009152e-02 5.168132e-02 13 20082016 20082130 115 + 1.665 1.835 0.575
ENSG00000121741 E049 94.6437108 0.0003281456 1.834531e-03 6.709649e-03 13 20082781 20083009 229 + 1.795 1.983 0.631
ENSG00000121741 E050 38.9378588 0.0005394931 2.259883e-02 5.691829e-02 13 20083010 20083032 23 + 1.415 1.619 0.700
ENSG00000121741 E051 0.2987644 0.0272923931 1.000000e+00   13 20083631 20083655 25 + 0.095 0.000 -10.387
ENSG00000121741 E052 71.4035879 0.0003545763 1.217002e-02 3.393694e-02 13 20083656 20083776 121 + 1.680 1.856 0.597
ENSG00000121741 E053 242.0247470 0.0241080599 6.676543e-05 3.644579e-04 13 20085822 20091829 6008 + 2.169 2.502 1.114