ENSG00000121680

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378750 ENSG00000121680 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX16 protein_coding protein_coding 30.15493 52.19406 14.40332 3.755831 0.9147195 -1.856759 7.521645 15.705798 1.710171 1.5494858 0.1293925 -3.191592 0.2237958 0.2999667 0.1185667 -0.18140000 1.429556e-15 1.429556e-15 FALSE TRUE
ENST00000527371 ENSG00000121680 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX16 protein_coding retained_intron 30.15493 52.19406 14.40332 3.755831 0.9147195 -1.856759 6.259316 7.826023 2.584588 1.2949854 0.7223785 -1.594616 0.2187083 0.1483000 0.1750333 0.02673333 8.366342e-01 1.429556e-15 FALSE FALSE
ENST00000532681 ENSG00000121680 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX16 protein_coding protein_coding 30.15493 52.19406 14.40332 3.755831 0.9147195 -1.856759 3.542862 6.413587 2.238941 0.6047082 0.3212684 -1.514133 0.1199542 0.1225667 0.1588000 0.03623333 6.420069e-01 1.429556e-15 FALSE TRUE
MSTRG.5440.3 ENSG00000121680 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX16 protein_coding   30.15493 52.19406 14.40332 3.755831 0.9147195 -1.856759 5.812219 10.037306 3.760814 0.8858272 0.1339383 -1.413861 0.1993708 0.1939000 0.2621667 0.06826667 1.743946e-01 1.429556e-15 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121680 E001 1.690849 0.0081333665 3.571679e-01 5.015744e-01 11 45909663 45909668 6 - 0.490 0.314 -0.977
ENSG00000121680 E002 75.315042 0.0003640654 9.933591e-02 1.894735e-01 11 45909669 45910169 501 - 1.659 1.752 0.313
ENSG00000121680 E003 18.400505 0.0010408900 4.940736e-01 6.310731e-01 11 45910170 45910177 8 - 1.085 1.157 0.261
ENSG00000121680 E004 26.911550 0.0007660261 2.689039e-02 6.576435e-02 11 45910178 45910204 27 - 1.109 1.327 0.770
ENSG00000121680 E005 129.115322 0.0002548705 9.848199e-01 9.945809e-01 11 45910205 45910312 108 - 1.969 1.969 0.000
ENSG00000121680 E006 167.290837 0.0002514511 1.885128e-01 3.118634e-01 11 45910898 45910962 65 - 2.041 2.089 0.161
ENSG00000121680 E007 6.163340 0.0026946480 7.527568e-01 8.388628e-01 11 45911899 45912015 117 - 0.770 0.720 -0.199
ENSG00000121680 E008 152.187021 0.0002261283 1.290690e-01 2.328826e-01 11 45913819 45913844 26 - 1.991 2.049 0.196
ENSG00000121680 E009 216.219432 0.0006685455 5.806650e-01 7.053591e-01 11 45913845 45913938 94 - 2.179 2.197 0.061
ENSG00000121680 E010 10.033090 0.0017284611 6.687902e-06 4.627511e-05 11 45914123 45914130 8 - 1.282 0.790 -1.812
ENSG00000121680 E011 172.000837 0.0006237001 1.508877e-02 4.068839e-02 11 45914131 45914203 73 - 2.015 2.109 0.314
ENSG00000121680 E012 11.179881 0.0015947881 4.424899e-04 1.937960e-03 11 45914264 45914315 52 - 1.249 0.868 -1.392
ENSG00000121680 E013 242.055311 0.0001794088 1.593324e-02 4.258193e-02 11 45914316 45914468 153 - 2.177 2.251 0.247
ENSG00000121680 E014 260.191474 0.0001796723 2.141033e-01 3.433638e-01 11 45914604 45914684 81 - 2.300 2.265 -0.119
ENSG00000121680 E015 146.726465 0.0002387062 1.813424e-01 3.029281e-01 11 45915468 45915468 1 - 2.067 2.016 -0.171
ENSG00000121680 E016 181.201565 0.0001972309 3.044212e-01 4.464305e-01 11 45915469 45915495 27 - 2.145 2.110 -0.119
ENSG00000121680 E017 239.176094 0.0002021957 8.175530e-01 8.846424e-01 11 45915496 45915568 73 - 2.228 2.234 0.021
ENSG00000121680 E018 325.695872 0.0005475487 1.435655e-01 2.528665e-01 11 45915703 45915836 134 - 2.333 2.373 0.134
ENSG00000121680 E019 275.105233 0.0001727635 3.517894e-01 4.960031e-01 11 45916227 45916303 77 - 2.317 2.290 -0.088
ENSG00000121680 E020 11.052019 0.0016280893 4.248342e-01 5.677741e-01 11 45916974 45917141 168 - 1.032 0.934 -0.363
ENSG00000121680 E021 192.694499 0.0002102656 4.780726e-01 6.165212e-01 11 45917458 45917493 36 - 2.162 2.138 -0.081
ENSG00000121680 E022 8.747438 0.0042201955 1.439528e-03 5.437971e-03 11 45917588 45917699 112 - 1.154 0.768 -1.445
ENSG00000121680 E023 186.184805 0.0002253963 8.532449e-01 9.091428e-01 11 45917700 45917773 74 - 2.132 2.125 -0.024
ENSG00000121680 E024 210.991955 0.0033514322 8.667618e-01 9.182465e-01 11 45917774 45918121 348 - 2.188 2.180 -0.027
ENSG00000121680 E025 69.671930 0.0022255023 1.036948e-05 6.868526e-05 11 45918122 45918812 691 - 1.894 1.657 -0.804