ENSG00000121644

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302550 ENSG00000121644 HEK293_OSMI2_2hA HEK293_TMG_2hB DESI2 protein_coding protein_coding 36.79126 23.83869 53.309 4.8373 1.983115 1.160739 17.309720 5.158812 27.5778419 0.2940523 1.7197437 2.416128 0.40857083 0.23636667 0.516800000 0.28043333 3.316276e-03 2.991899e-23 FALSE TRUE
MSTRG.3389.15 ENSG00000121644 HEK293_OSMI2_2hA HEK293_TMG_2hB DESI2 protein_coding   36.79126 23.83869 53.309 4.8373 1.983115 1.160739 2.879306 2.792065 1.3557145 1.2188193 0.7158622 -1.036834 0.09471250 0.10713333 0.025966667 -0.08116667 3.960160e-01 2.991899e-23 FALSE TRUE
MSTRG.3389.17 ENSG00000121644 HEK293_OSMI2_2hA HEK293_TMG_2hB DESI2 protein_coding   36.79126 23.83869 53.309 4.8373 1.983115 1.160739 5.116999 9.885361 0.0000000 4.1594609 0.0000000 -9.950609 0.17402917 0.38270000 0.000000000 -0.38270000 2.991899e-23 2.991899e-23   FALSE
MSTRG.3389.2 ENSG00000121644 HEK293_OSMI2_2hA HEK293_TMG_2hB DESI2 protein_coding   36.79126 23.83869 53.309 4.8373 1.983115 1.160739 1.174105 2.631061 0.4819197 0.2023641 0.2597352 -2.424623 0.05440833 0.12106667 0.008766667 -0.11230000 3.058464e-02 2.991899e-23 TRUE FALSE
MSTRG.3389.4 ENSG00000121644 HEK293_OSMI2_2hA HEK293_TMG_2hB DESI2 protein_coding   36.79126 23.83869 53.309 4.8373 1.983115 1.160739 4.991374 1.324768 13.3793526 0.3059798 0.3266522 3.326426 0.11585417 0.06276667 0.251266667 0.18850000 1.257262e-03 2.991899e-23 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121644 E001 0.5891098 0.0182862205 1.911462e-01 3.151658e-01 1 244653057 244653065 9 + 0.227 0.000 -25.932
ENSG00000121644 E002 0.4439371 0.0215722317 3.177113e-01 4.605991e-01 1 244653066 244653068 3 + 0.181 0.000 -25.515
ENSG00000121644 E003 0.5911862 0.0172671820 1.904402e-01 3.143095e-01 1 244653069 244653074 6 + 0.227 0.000 -25.930
ENSG00000121644 E004 1.3275450 0.0095966680 2.059766e-02 5.274124e-02 1 244653075 244653079 5 + 0.406 0.000 -27.100
ENSG00000121644 E005 1.6263095 0.0084305888 9.023537e-03 2.633741e-02 1 244653080 244653081 2 + 0.461 0.000 -27.390
ENSG00000121644 E006 13.1955255 0.0020386894 6.423423e-09 8.212297e-08 1 244653082 244653102 21 + 1.184 0.611 -2.212
ENSG00000121644 E007 27.1783591 0.0010647532 4.077098e-11 7.674058e-10 1 244653103 244653125 23 + 1.460 1.082 -1.329
ENSG00000121644 E008 36.4096835 0.0050081341 2.205440e-11 4.344988e-10 1 244653126 244653140 15 + 1.581 1.215 -1.270
ENSG00000121644 E009 162.2327456 0.0257567546 3.467463e-03 1.163191e-02 1 244653141 244653355 215 + 2.170 2.093 -0.259
ENSG00000121644 E010 16.0937768 0.0509320025 3.724202e-03 1.236725e-02 1 244653356 244653750 395 + 0.958 1.511 1.961
ENSG00000121644 E011 8.6466688 0.1490514089 9.633015e-02 1.848720e-01 1 244653751 244653794 44 + 0.751 1.232 1.790
ENSG00000121644 E012 13.9085134 0.0693109646 1.031477e-02 2.954315e-02 1 244653795 244653912 118 + 0.905 1.449 1.944
ENSG00000121644 E013 16.9470492 0.0261090492 1.222867e-07 1.221751e-06 1 244653913 244653938 26 + 0.857 1.617 2.706
ENSG00000121644 E014 26.9361301 0.0130121080 5.770592e-12 1.247827e-10 1 244653939 244654025 87 + 1.040 1.811 2.677
ENSG00000121644 E015 4.3468172 0.0051914525 5.787308e-03 1.805408e-02 1 244654026 244654037 12 + 0.486 1.035 2.252
ENSG00000121644 E016 25.4032674 0.0368406024 2.385287e-17 1.106478e-15 1 244656296 244656549 254 + 0.695 1.883 4.253
ENSG00000121644 E017 1.8907428 0.0087167759 2.647303e-01 4.027170e-01 1 244672404 244672418 15 + 0.435 0.349 -0.481
ENSG00000121644 E018 2.4882717 0.0132729312 9.303933e-02 1.798775e-01 1 244672419 244672461 43 + 0.533 0.349 -0.966
ENSG00000121644 E019 7.9754519 0.0066374114 1.147396e-06 9.407545e-06 1 244681868 244681932 65 + 0.990 0.349 -2.832
ENSG00000121644 E020 136.7859096 0.0070171860 7.617440e-10 1.154481e-08 1 244686597 244686669 73 + 2.113 1.958 -0.518
ENSG00000121644 E021 126.0862891 0.0002972054 6.089228e-17 2.688385e-15 1 244689249 244689342 94 + 2.069 1.964 -0.351
ENSG00000121644 E022 81.7653333 0.0003626528 3.893150e-11 7.358531e-10 1 244691879 244691880 2 + 1.881 1.783 -0.328
ENSG00000121644 E023 80.6149496 0.0009996203 8.396407e-10 1.261739e-08 1 244691881 244691883 3 + 1.874 1.783 -0.305
ENSG00000121644 E024 191.7249053 0.0042305163 4.731046e-07 4.204148e-06 1 244691884 244692020 137 + 2.231 2.206 -0.086
ENSG00000121644 E025 4.6342998 0.0225378073 1.807605e-03 6.623061e-03 1 244699861 244700033 173 + 0.777 0.349 -2.016
ENSG00000121644 E026 3147.6504004 0.0259058736 1.571939e-02 4.210425e-02 1 244705556 244709033 3478 + 3.363 3.603 0.798