ENSG00000121579

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000240922 ENSG00000121579 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA50 protein_coding protein_coding 100.5335 37.59331 190.6916 1.514145 4.548836 2.342385 32.34948 17.624975 56.65966 2.2103729 3.256250 1.684137 0.3785125 0.4670000 0.2966667 -0.1703333 0.014219572 0.002558102 FALSE TRUE
ENST00000477813 ENSG00000121579 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA50 protein_coding protein_coding 100.5335 37.59331 190.6916 1.514145 4.548836 2.342385 33.35697 6.902951 67.15477 0.8228642 2.446515 3.280331 0.2748042 0.1857000 0.3521000 0.1664000 0.002558102 0.002558102 FALSE FALSE
ENST00000493900 ENSG00000121579 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA50 protein_coding protein_coding 100.5335 37.59331 190.6916 1.514145 4.548836 2.342385 34.17921 13.019547 66.22290 1.2843600 1.871945 2.345761 0.3389583 0.3459667 0.3477667 0.0018000 1.000000000 0.002558102 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121579 E001 3346.4691364 6.556364e-03 7.594750e-06 5.184127e-05 3 113716458 113720314 3857 - 3.402 3.581 0.595
ENSG00000121579 E002 1740.0410558 8.817806e-05 4.758203e-04 2.067636e-03 3 113720315 113720929 615 - 3.167 3.171 0.013
ENSG00000121579 E003 1631.2998268 4.199039e-04 2.708652e-13 7.244755e-12 3 113720930 113721428 499 - 3.153 3.090 -0.209
ENSG00000121579 E004 391.0818348 1.474237e-04 1.217982e-05 7.932313e-05 3 113721429 113721456 28 - 2.533 2.475 -0.194
ENSG00000121579 E005 550.6539269 1.606707e-03 1.699438e-03 6.282007e-03 3 113721457 113721589 133 - 2.678 2.630 -0.161
ENSG00000121579 E006 287.7538154 6.303525e-03 6.143831e-01 7.328705e-01 3 113721590 113721655 66 - 2.385 2.392 0.025
ENSG00000121579 E007 479.1789781 7.129219e-04 4.344244e-02 9.736467e-02 3 113721656 113721759 104 - 2.587 2.672 0.282
ENSG00000121579 E008 424.4656275 2.004255e-04 2.542338e-04 1.192794e-03 3 113721760 113721816 57 - 2.528 2.643 0.384
ENSG00000121579 E009 640.0141676 1.737111e-04 1.643072e-05 1.039177e-04 3 113721817 113721937 121 - 2.706 2.819 0.375
ENSG00000121579 E010 480.2824977 1.299723e-04 3.086810e-01 4.509527e-01 3 113722906 113722972 67 - 2.595 2.655 0.200
ENSG00000121579 E011 576.6203827 1.632057e-03 2.667346e-01 4.049782e-01 3 113723422 113723486 65 - 2.686 2.693 0.023
ENSG00000121579 E012 538.3783020 1.852634e-03 3.535060e-02 8.232410e-02 3 113723487 113723517 31 - 2.663 2.640 -0.075
ENSG00000121579 E013 389.8609320 2.386852e-03 8.084463e-02 1.608614e-01 3 113723518 113723518 1 - 2.523 2.503 -0.066
ENSG00000121579 E014 445.8909817 1.947554e-03 1.535382e-02 4.129262e-02 3 113723519 113723541 23 - 2.584 2.549 -0.117
ENSG00000121579 E015 2.7743507 5.502197e-03 2.569617e-01 3.939932e-01 3 113723542 113723596 55 - 0.556 0.363 -0.988
ENSG00000121579 E016 480.6486097 1.570202e-03 3.745224e-03 1.242508e-02 3 113723959 113723980 22 - 2.618 2.576 -0.142
ENSG00000121579 E017 778.1600771 4.630587e-04 8.821242e-09 1.098434e-07 3 113723981 113724092 112 - 2.833 2.766 -0.223
ENSG00000121579 E018 271.3905662 1.585673e-03 3.027891e-06 2.263266e-05 3 113724093 113724095 3 - 2.387 2.270 -0.392
ENSG00000121579 E019 2.1497664 1.720458e-02 5.110161e-01 6.461323e-01 3 113724593 113724597 5 - 0.469 0.363 -0.574
ENSG00000121579 E020 3.1011260 4.883344e-03 7.037584e-01 8.024137e-01 3 113739426 113739587 162 - 0.535 0.630 0.426
ENSG00000121579 E021 0.5869198 1.890503e-01 4.373640e-01 5.793284e-01 3 113745742 113745941 200 - 0.217 0.000 -9.472
ENSG00000121579 E022 838.4646588 1.437627e-03 6.710196e-06 4.640360e-05 3 113745942 113746300 359 - 2.865 2.799 -0.222