ENSG00000121486

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367506 ENSG00000121486 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT1L protein_coding protein_coding 10.56365 3.720469 14.68459 0.3546735 0.8226194 1.977857 7.008214 3.1271414 9.608253 0.3155534 0.2719266 1.616324 0.74644167 0.8458 0.6579000 -0.187900000 1.436014e-01 1.743801e-09 FALSE TRUE
ENST00000458395 ENSG00000121486 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT1L protein_coding protein_coding 10.56365 3.720469 14.68459 0.3546735 0.8226194 1.977857 1.739923 0.5933274 2.156982 0.2654505 0.4141742 1.844674 0.14162083 0.1542 0.1474333 -0.006766667 1.000000e+00 1.743801e-09 FALSE FALSE
ENST00000487028 ENSG00000121486 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT1L protein_coding processed_transcript 10.56365 3.720469 14.68459 0.3546735 0.8226194 1.977857 1.737467 0.0000000 2.919359 0.0000000 0.7268610 8.194441 0.09845833 0.0000 0.1946667 0.194666667 1.743801e-09 1.743801e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121486 E001 221.6646937 0.0106553564 6.504616e-08 6.850948e-07 1 185118101 185120052 1952 - 2.189 2.495 1.019
ENSG00000121486 E002 78.8608096 0.0037974980 2.295308e-01 3.618745e-01 1 185120053 185120271 219 - 1.816 1.918 0.342
ENSG00000121486 E003 74.7213086 0.0003956863 9.750537e-01 9.884538e-01 1 185120383 185120509 127 - 1.814 1.852 0.130
ENSG00000121486 E004 0.1472490 0.0436373547 1.000000e+00   1 185120510 185120869 360 - 0.071 0.000 -7.969
ENSG00000121486 E005 58.0481988 0.0033708498 7.949881e-01 8.690385e-01 1 185123857 185123919 63 - 1.711 1.732 0.070
ENSG00000121486 E006 1.9550688 0.0872696290 3.089758e-04 1.416067e-03 1 185124840 185124943 104 - 0.132 0.835 4.037
ENSG00000121486 E007 92.0708136 0.0032381918 3.075881e-01 4.498084e-01 1 185124944 185125110 167 - 1.892 1.977 0.285
ENSG00000121486 E008 57.0827429 0.0031281967 1.515095e-01 2.637223e-01 1 185128669 185128747 79 - 1.680 1.797 0.397
ENSG00000121486 E009 78.8554578 0.0018156015 3.488989e-01 4.931130e-01 1 185137606 185137796 191 - 1.851 1.845 -0.022
ENSG00000121486 E010 83.0671820 0.0003340563 4.089418e-01 5.525523e-01 1 185139367 185139579 213 - 1.868 1.870 0.006
ENSG00000121486 E011 111.1060693 0.0013775713 8.259214e-01 8.904260e-01 1 185139973 185140222 250 - 1.984 2.013 0.098
ENSG00000121486 E012 67.5385865 0.0016386814 5.925434e-03 1.841312e-02 1 185143357 185143436 80 - 1.807 1.697 -0.369
ENSG00000121486 E013 39.6342463 0.0013246453 2.065348e-01 3.343822e-01 1 185143906 185143919 14 - 1.566 1.520 -0.157
ENSG00000121486 E014 63.7516599 0.0004441817 1.718232e-01 2.905829e-01 1 185143920 185144029 110 - 1.763 1.732 -0.107
ENSG00000121486 E015 70.5702652 0.0004140824 6.722895e-04 2.797102e-03 1 185145439 185145568 130 - 1.829 1.697 -0.446
ENSG00000121486 E016 53.7356396 0.0033054486 4.907324e-03 1.567198e-02 1 185147182 185147246 65 - 1.713 1.573 -0.475
ENSG00000121486 E017 62.5622287 0.0004496153 1.299387e-04 6.586176e-04 1 185150379 185150492 114 - 1.786 1.617 -0.570
ENSG00000121486 E018 50.8862713 0.0242949129 2.973641e-03 1.018472e-02 1 185151825 185151935 111 - 1.714 1.466 -0.845
ENSG00000121486 E019 70.0161211 0.0013811860 4.197458e-05 2.407277e-04 1 185156478 185156953 476 - 1.839 1.659 -0.609
ENSG00000121486 E020 0.4502799 0.0273375077 4.420807e-01 5.837436e-01 1 185156984 185157072 89 - 0.186 0.000 -9.555