ENSG00000121440

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263666 ENSG00000121440 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZRN3 protein_coding protein_coding 3.488103 3.376221 4.531237 0.2588731 0.2281648 0.4234091 1.8133036 1.5123856 2.7469498 0.2517905 0.10032232 0.8567392 0.519287500 0.46556667 0.6086000 0.14303333 5.689325e-01 1.336069e-15 FALSE TRUE
ENST00000462146 ENSG00000121440 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZRN3 protein_coding protein_coding 3.488103 3.376221 4.531237 0.2588731 0.2281648 0.4234091 0.0240729 0.1925832 0.0000000 0.1925832 0.00000000 -4.3404427 0.006641667 0.05313333 0.0000000 -0.05313333 7.332646e-01 1.336069e-15 FALSE TRUE
ENST00000466780 ENSG00000121440 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZRN3 protein_coding protein_coding 3.488103 3.376221 4.531237 0.2588731 0.2281648 0.4234091 0.7171183 0.0000000 1.2770086 0.0000000 0.06431802 7.0078778 0.188670833 0.00000000 0.2845667 0.28456667 1.336069e-15 1.336069e-15 FALSE TRUE
ENST00000494559 ENSG00000121440 HEK293_OSMI2_2hA HEK293_TMG_2hB PDZRN3 protein_coding protein_coding 3.488103 3.376221 4.531237 0.2588731 0.2281648 0.4234091 0.7007019 1.4403257 0.1946487 0.2906384 0.19464868 -2.8251557 0.217466667 0.41793333 0.0421000 -0.37583333 2.909019e-02 1.336069e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121440 E001 0.0000000       3 73382431 73382432 2 -      
ENSG00000121440 E002 60.8507046 0.0005678087 3.421803e-13 9.017253e-12 3 73382433 73382898 466 - 1.613 1.932 1.078
ENSG00000121440 E003 34.8447591 0.0029904522 4.718486e-11 8.798258e-10 3 73382899 73383078 180 - 1.314 1.729 1.422
ENSG00000121440 E004 15.3767073 0.0174570058 1.394422e-02 3.809500e-02 3 73383079 73383135 57 - 1.075 1.328 0.899
ENSG00000121440 E005 90.1344653 0.0073625055 3.893483e-01 5.334536e-01 3 73383136 73383805 670 - 1.938 1.980 0.142
ENSG00000121440 E006 45.4655463 0.0008360462 5.492583e-01 6.790085e-01 3 73383806 73384182 377 - 1.646 1.675 0.099
ENSG00000121440 E007 30.7106116 0.0068944557 3.872896e-01 5.314379e-01 3 73384183 73384469 287 - 1.523 1.459 -0.222
ENSG00000121440 E008 28.1476561 0.0007824726 9.175797e-01 9.519186e-01 3 73384470 73384648 179 - 1.463 1.468 0.019
ENSG00000121440 E009 45.3514811 0.0008228247 3.672610e-01 5.116371e-01 3 73384649 73384930 282 - 1.682 1.634 -0.163
ENSG00000121440 E010 13.6364031 0.0024671699 5.095727e-02 1.108691e-01 3 73385669 73385697 29 - 1.232 1.046 -0.665
ENSG00000121440 E011 19.4035354 0.0011159695 3.451775e-01 4.892514e-01 3 73385698 73385785 88 - 1.342 1.267 -0.259
ENSG00000121440 E012 11.4195629 0.0022246209 8.880558e-01 9.324571e-01 3 73387968 73387986 19 - 1.104 1.089 -0.053
ENSG00000121440 E013 15.9100493 0.0287161948 3.454631e-01 4.895573e-01 3 73387987 73388069 83 - 1.279 1.171 -0.380
ENSG00000121440 E014 0.2965864 0.1351850418 1.430219e-01   3 73388070 73388146 77 - 0.000 0.247 10.995
ENSG00000121440 E015 14.8151274 0.1059517778 4.026388e-01 5.464091e-01 3 73389816 73389878 63 - 1.253 1.137 -0.412
ENSG00000121440 E016 21.1979735 0.0017697144 1.850329e-02 4.823845e-02 3 73391018 73391083 66 - 1.420 1.239 -0.631
ENSG00000121440 E017 18.2377418 0.0135722753 4.266409e-02 9.593002e-02 3 73391084 73391101 18 - 1.363 1.165 -0.695
ENSG00000121440 E018 16.4924863 0.0014926228 3.148081e-02 7.484590e-02 3 73391102 73391116 15 - 1.314 1.129 -0.654
ENSG00000121440 E019 26.8250407 0.0013256923 9.072527e-02 1.762798e-01 3 73400922 73401009 88 - 1.494 1.379 -0.396
ENSG00000121440 E020 0.1451727 0.0462139337 6.789697e-01   3 73401010 73401082 73 - 0.105 0.000 -9.259
ENSG00000121440 E021 0.8847512 0.1754081487 9.812353e-01 9.922976e-01 3 73401769 73401913 145 - 0.259 0.254 -0.035
ENSG00000121440 E022 0.0000000       3 73402444 73402503 60 -      
ENSG00000121440 E023 39.2281188 0.0051920327 8.495186e-02 1.673273e-01 3 73404148 73404395 248 - 1.654 1.546 -0.369
ENSG00000121440 E024 0.4481018 0.0927603054 4.072862e-01 5.508678e-01 3 73404396 73404563 168 - 0.105 0.248 1.500
ENSG00000121440 E025 0.0000000       3 73408058 73408260 203 -      
ENSG00000121440 E026 0.0000000       3 73433639 73433904 266 -      
ENSG00000121440 E027 0.0000000       3 73474455 73474632 178 -      
ENSG00000121440 E028 0.0000000       3 73556700 73556938 239 -      
ENSG00000121440 E029 0.0000000       3 73561451 73561618 168 -      
ENSG00000121440 E030 0.0000000       3 73569151 73569461 311 -      
ENSG00000121440 E031 16.7448293 0.0153102027 1.970093e-02 5.085408e-02 3 73602354 73602461 108 - 1.347 1.113 -0.826
ENSG00000121440 E032 10.3385029 0.0017289633 3.645450e-04 1.636772e-03 3 73608598 73608684 87 - 1.196 0.809 -1.432
ENSG00000121440 E033 18.8799389 0.0152045588 6.658074e-04 2.773483e-03 3 73624103 73624941 839 - 1.420 1.077 -1.213