ENSG00000121417

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000240731 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding protein_coding 3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.3917259 0.12402776 0.2509436 0.12402776 0.2509436 0.96120632 0.12131667 0.07660000 0.07803333 0.001433333 0.95217747 0.01615586 FALSE TRUE
ENST00000299871 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding protein_coding 3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.1960935 0.06105601 0.2822913 0.06105601 0.1951905 2.04037814 0.05645000 0.02893333 0.06600000 0.037066667 0.79351916 0.01615586 FALSE TRUE
ENST00000347302 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding protein_coding 3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.2896252 0.28555409 0.4581216 0.10014532 0.2918016 0.66346116 0.10211667 0.15883333 0.10733333 -0.051500000 0.79548064 0.01615586 FALSE TRUE
ENST00000391703 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding protein_coding 3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.1190768 0.00000000 0.3405823 0.00000000 0.3405823 5.13168105 0.02850833 0.00000000 0.08230000 0.082300000 0.92593679 0.01615586 FALSE TRUE
ENST00000407202 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding protein_coding 3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.2453002 0.37578811 0.0000000 0.19383754 0.0000000 -5.26973678 0.08648333 0.17873333 0.00000000 -0.178733333 0.05606142 0.01615586 FALSE TRUE
ENST00000535785 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding nonsense_mediated_decay 3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.1699249 0.18363516 0.1515932 0.18363516 0.1515932 -0.26097461 0.05084583 0.08773333 0.04713333 -0.040600000 0.90870737 0.01615586 FALSE TRUE
ENST00000541072 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding retained_intron 3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.3098246 0.13245365 0.2350775 0.09298778 0.1667085 0.78274524 0.08649167 0.06290000 0.05630000 -0.006600000 0.94318357 0.01615586   FALSE
ENST00000541801 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding protein_coding 3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.4167501 0.00000000 0.4809807 0.00000000 0.2270369 5.61759448 0.12784583 0.00000000 0.13683333 0.136833333 0.01615586 0.01615586 FALSE TRUE
ENST00000542008 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding retained_intron 3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.4299671 0.09099216 0.4074469 0.09099216 0.2335327 2.04734924 0.12500833 0.04313333 0.10526667 0.062133333 0.71534505 0.01615586   FALSE
MSTRG.17805.1 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding   3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.3068527 0.54523889 0.5167673 0.12815844 0.2037164 -0.07594285 0.10867917 0.27553333 0.13310000 -0.142433333 0.25627183 0.01615586 FALSE TRUE
MSTRG.17805.10 ENSG00000121417 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF211 protein_coding   3.204903 1.940506 3.891715 0.160839 0.3416064 1.00026 0.0651381 0.00000000 0.2684352 0.00000000 0.2684352 4.79926954 0.02054167 0.00000000 0.06213333 0.062133333 0.91618275 0.01615586 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121417 E001 0.7394793 0.015719406 0.432368415 0.57481961 19 57630355 57630394 40 + 0.264 0.178 -0.726
ENSG00000121417 E002 0.9953799 0.012545320 0.501076193 0.63725476 19 57630395 57630494 100 + 0.211 0.401 1.276
ENSG00000121417 E003 0.0000000       19 57633167 57633167 1 +      
ENSG00000121417 E004 0.5827671 0.094510422 0.143077039 0.25221707 19 57633168 57633180 13 + 0.264 0.000 -15.478
ENSG00000121417 E005 1.7661690 0.113209913 0.286569344 0.42698437 19 57633181 57633185 5 + 0.459 0.307 -0.870
ENSG00000121417 E006 2.0649335 0.055617310 0.134647235 0.24061232 19 57633186 57633196 11 + 0.518 0.306 -1.172
ENSG00000121417 E007 2.6863086 0.080016909 0.176702223 0.29695898 19 57633197 57633198 2 + 0.594 0.404 -0.928
ENSG00000121417 E008 3.6356936 0.155632295 0.200596858 0.32694237 19 57633199 57633215 17 + 0.695 0.490 -0.923
ENSG00000121417 E009 4.2236575 0.108244423 0.174949058 0.29460693 19 57633216 57633224 9 + 0.747 0.553 -0.834
ENSG00000121417 E010 5.9877753 0.041011692 0.197999371 0.32371566 19 57633225 57633246 22 + 0.848 0.748 -0.398
ENSG00000121417 E011 11.1236579 0.002158529 0.025047141 0.06197244 19 57633247 57633436 190 + 1.090 0.983 -0.391
ENSG00000121417 E012 3.2244245 0.006153674 0.442144341 0.58378695 19 57633713 57633785 73 + 0.519 0.745 0.986
ENSG00000121417 E013 4.4704090 0.003671308 0.489900264 0.62726694 19 57633786 57633905 120 + 0.638 0.850 0.860
ENSG00000121417 E014 2.7971753 0.085412877 0.675098400 0.78046846 19 57633906 57634022 117 + 0.490 0.661 0.775
ENSG00000121417 E015 6.4985483 0.038402145 0.176321537 0.29645842 19 57634023 57634061 39 + 0.885 0.783 -0.398
ENSG00000121417 E016 3.9419692 0.019803472 0.804935435 0.87588082 19 57634062 57634283 222 + 0.638 0.705 0.283
ENSG00000121417 E017 15.1124681 0.002296130 0.062226498 0.13039215 19 57634629 57634755 127 + 1.200 1.166 -0.120
ENSG00000121417 E018 9.8859192 0.001808693 0.009171641 0.02671289 19 57639912 57640067 156 + 1.067 0.908 -0.590
ENSG00000121417 E019 192.0043738 0.051583076 0.046237613 0.10247516 19 57640704 57644041 3338 + 2.181 2.386 0.685