ENSG00000121274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000561678 ENSG00000121274 HEK293_OSMI2_2hA HEK293_TMG_2hB TENT4B protein_coding protein_coding 6.119389 1.578406 11.32488 0.243805 0.3448556 2.835117 0.4465863 0.12024871 1.1413201 0.06111038 0.006967243 3.1439481 0.06184167 0.07593333 0.10100000 0.02506667 7.531580e-01 5.513768e-12 FALSE TRUE
ENST00000562717 ENSG00000121274 HEK293_OSMI2_2hA HEK293_TMG_2hB TENT4B protein_coding processed_transcript 6.119389 1.578406 11.32488 0.243805 0.3448556 2.835117 1.6818399 0.04820672 2.9076282 0.02601057 0.425821822 5.6474666 0.20084583 0.03116667 0.25506667 0.22390000 2.348478e-05 5.513768e-12 TRUE TRUE
MSTRG.12617.2 ENSG00000121274 HEK293_OSMI2_2hA HEK293_TMG_2hB TENT4B protein_coding   6.119389 1.578406 11.32488 0.243805 0.3448556 2.835117 1.7376471 0.83923255 3.0908118 0.10814908 0.411746441 1.8684144 0.36753333 0.53780000 0.27413333 -0.26366667 1.692896e-02 5.513768e-12 FALSE TRUE
MSTRG.12617.5 ENSG00000121274 HEK293_OSMI2_2hA HEK293_TMG_2hB TENT4B protein_coding   6.119389 1.578406 11.32488 0.243805 0.3448556 2.835117 0.4397616 0.13760828 0.6235531 0.13760828 0.339189902 2.1016919 0.08118750 0.10283333 0.05693333 -0.04590000 8.894026e-01 5.513768e-12 FALSE TRUE
MSTRG.12617.6 ENSG00000121274 HEK293_OSMI2_2hA HEK293_TMG_2hB TENT4B protein_coding   6.119389 1.578406 11.32488 0.243805 0.3448556 2.835117 0.2650643 0.43310969 0.5301038 0.23810342 0.530103794 0.2855728 0.11986667 0.25223333 0.04426667 -0.20796667 3.309627e-01 5.513768e-12 FALSE TRUE
MSTRG.12617.7 ENSG00000121274 HEK293_OSMI2_2hA HEK293_TMG_2hB TENT4B protein_coding   6.119389 1.578406 11.32488 0.243805 0.3448556 2.835117 1.4897457 0.00000000 2.9786828 0.00000000 0.123866974 8.2233660 0.13796250 0.00000000 0.26386667 0.26386667 5.513768e-12 5.513768e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121274 E001 0.0000000       16 50152911 50152918 8 +      
ENSG00000121274 E002 0.1451727 0.0440640028 1.000000e+00   16 50152919 50152919 1 + 0.056 0.000 -7.491
ENSG00000121274 E003 0.1451727 0.0440640028 1.000000e+00   16 50152920 50152928 9 + 0.056 0.000 -9.249
ENSG00000121274 E004 0.9726796 0.2718484411 9.617913e-01 9.799105e-01 16 50152929 50152939 11 + 0.228 0.252 0.190
ENSG00000121274 E005 2.0013464 0.0198569248 3.144849e-01 4.571967e-01 16 50152940 50153032 93 + 0.423 0.249 -1.090
ENSG00000121274 E006 9.2021650 0.0078027770 3.843750e-01 5.285323e-01 16 50153306 50153648 343 + 0.910 0.856 -0.206
ENSG00000121274 E007 10.3814289 0.0018792379 3.230921e-01 4.664197e-01 16 50153649 50153674 26 + 0.959 0.900 -0.220
ENSG00000121274 E008 11.8501077 0.0014595852 1.365217e-01 2.432184e-01 16 50153675 50153743 69 + 1.020 0.900 -0.446
ENSG00000121274 E009 6.6734641 0.0195820957 1.165684e-01 2.150517e-01 16 50153744 50153746 3 + 0.821 0.610 -0.869
ENSG00000121274 E010 49.7720198 0.0005411651 7.203390e-06 4.945318e-05 16 50153747 50154160 414 + 1.628 1.383 -0.839
ENSG00000121274 E011 37.8737341 0.0006123379 2.018138e-03 7.282443e-03 16 50154161 50154259 99 + 1.503 1.339 -0.567
ENSG00000121274 E012 43.3626343 0.0005061156 1.905665e-03 6.933010e-03 16 50211323 50211446 124 + 1.558 1.410 -0.508
ENSG00000121274 E013 22.4546620 0.0009970088 1.061009e-02 3.023357e-02 16 50214221 50214225 5 + 1.284 1.100 -0.656
ENSG00000121274 E014 32.3431757 0.0215734041 7.394009e-02 1.498153e-01 16 50214226 50214267 42 + 1.428 1.294 -0.466
ENSG00000121274 E015 48.4480433 0.0005594422 2.748091e-03 9.516298e-03 16 50216075 50216195 121 + 1.599 1.471 -0.437
ENSG00000121274 E016 47.8121039 0.0073738762 2.041184e-03 7.354017e-03 16 50217556 50217663 108 + 1.602 1.422 -0.618
ENSG00000121274 E017 56.3186833 0.0003932505 9.772084e-02 1.870208e-01 16 50222306 50222434 129 + 1.650 1.630 -0.066
ENSG00000121274 E018 90.1881445 0.0003268856 2.445181e-02 6.075336e-02 16 50223174 50223387 214 + 1.850 1.824 -0.090
ENSG00000121274 E019 0.5901540 0.0197678475 7.054031e-01 8.037707e-01 16 50223388 50223400 13 + 0.150 0.248 0.906
ENSG00000121274 E020 79.4766954 0.0013428062 4.155173e-01 5.588977e-01 16 50224657 50224783 127 + 1.785 1.823 0.129
ENSG00000121274 E021 76.0395484 0.0003351070 5.778988e-02 1.228373e-01 16 50224891 50224994 104 + 1.776 1.758 -0.059
ENSG00000121274 E022 0.1472490 0.0447336567 1.000000e+00   16 50224995 50225011 17 + 0.056 0.000 -9.246
ENSG00000121274 E023 52.0448737 0.0006913742 3.509771e-02 8.183031e-02 16 50225098 50225238 141 + 1.619 1.562 -0.193
ENSG00000121274 E024 53.7197542 0.0008683499 1.548623e-01 2.682349e-01 16 50225239 50225285 47 + 1.623 1.614 -0.031
ENSG00000121274 E025 102.1009527 0.0013971786 4.819521e-04 2.091116e-03 16 50227839 50228003 165 + 1.911 1.819 -0.312
ENSG00000121274 E026 63.8895178 0.0005278254 8.667044e-04 3.497147e-03 16 50229152 50229197 46 + 1.717 1.598 -0.407
ENSG00000121274 E027 461.3020379 0.0041506561 5.894305e-22 4.672211e-20 16 50229198 50234925 5728 + 2.475 2.790 1.049
ENSG00000121274 E028 1.3567018 0.0109882367 7.310836e-01 8.228273e-01 16 50234926 50235310 385 + 0.292 0.405 0.685