ENSG00000121152

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000240423 ENSG00000121152 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPH protein_coding protein_coding 40.37148 31.58539 50.55474 0.9900549 1.339448 0.6784177 9.459234 9.745602 11.44420 0.4372127 0.5237051 0.2315744 0.2430500 0.3086333 0.2264000 -0.08223333 0.003256255 0.003256255 FALSE  
ENST00000435975 ENSG00000121152 HEK293_OSMI2_2hA HEK293_TMG_2hB NCAPH protein_coding protein_coding 40.37148 31.58539 50.55474 0.9900549 1.339448 0.6784177 27.501033 19.639160 35.02734 0.6873612 0.9238139 0.8344257 0.6679042 0.6220333 0.6928667 0.07083333 0.032434945 0.003256255 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121152 E001 2.8241195 0.0335720748 6.937816e-02 1.423318e-01 2 96334986 96335753 768 + 0.707 0.389 -1.498
ENSG00000121152 E002 6.8740789 0.0024241975 7.977833e-04 3.251461e-03 2 96335754 96335765 12 + 1.051 0.629 -1.656
ENSG00000121152 E003 34.9875108 0.0007108698 1.749571e-03 6.438944e-03 2 96335766 96335795 30 + 1.638 1.454 -0.629
ENSG00000121152 E004 39.1463586 0.0005464777 7.635959e-04 3.127534e-03 2 96335796 96335800 5 + 1.688 1.501 -0.637
ENSG00000121152 E005 42.7538630 0.0004897539 2.844949e-04 1.316834e-03 2 96335801 96335806 6 + 1.728 1.535 -0.658
ENSG00000121152 E006 67.2705932 0.0003845225 3.503803e-08 3.891797e-07 2 96335807 96335817 11 + 1.937 1.697 -0.810
ENSG00000121152 E007 134.8529653 0.0004737174 1.062784e-07 1.074278e-06 2 96335818 96335848 31 + 2.210 2.043 -0.558
ENSG00000121152 E008 3.0623105 0.0051176390 6.808746e-02 1.401909e-01 2 96341392 96341641 250 + 0.441 0.727 1.303
ENSG00000121152 E009 92.2446789 0.0005847771 7.988688e-05 4.272941e-04 2 96341642 96341674 33 + 2.039 1.892 -0.494
ENSG00000121152 E010 161.2512756 0.0019805986 1.524621e-05 9.714614e-05 2 96341675 96341713 39 + 2.280 2.130 -0.502
ENSG00000121152 E011 288.7257457 0.0021425180 1.367899e-05 8.803655e-05 2 96341714 96341894 181 + 2.522 2.391 -0.437
ENSG00000121152 E012 212.3896598 0.0012013451 3.396332e-04 1.538927e-03 2 96342050 96342140 91 + 2.377 2.275 -0.342
ENSG00000121152 E013 228.3764151 0.0061337637 4.145895e-02 9.373536e-02 2 96342756 96342848 93 + 2.402 2.312 -0.301
ENSG00000121152 E014 323.5837740 0.0030432749 1.651197e-03 6.124968e-03 2 96343166 96343304 139 + 2.558 2.456 -0.341
ENSG00000121152 E015 324.0137322 0.0005564845 6.807773e-05 3.708840e-04 2 96344105 96344229 125 + 2.552 2.466 -0.288
ENSG00000121152 E016 363.8116455 0.0001869418 1.754434e-01 2.952505e-01 2 96351831 96352020 190 + 2.574 2.551 -0.075
ENSG00000121152 E017 275.2684294 0.0005947912 6.934179e-01 7.944528e-01 2 96353306 96353397 92 + 2.438 2.451 0.043
ENSG00000121152 E018 0.2934659 0.0289684673 8.855702e-01   2 96353398 96353402 5 + 0.112 0.134 0.299
ENSG00000121152 E019 435.3524678 0.0001602854 4.615955e-02 1.023297e-01 2 96354183 96354388 206 + 2.656 2.625 -0.104
ENSG00000121152 E020 341.4210519 0.0001813754 3.137881e-01 4.564250e-01 2 96359045 96359193 149 + 2.545 2.528 -0.054
ENSG00000121152 E021 2.1883614 0.0072918123 6.968074e-02 1.428350e-01 2 96359194 96359452 259 + 0.626 0.319 -1.572
ENSG00000121152 E022 271.2695053 0.0001868990 4.487631e-01 5.900217e-01 2 96360143 96360249 107 + 2.444 2.431 -0.043
ENSG00000121152 E023 376.0086963 0.0004312738 6.284689e-01 7.440045e-01 2 96360588 96360710 123 + 2.582 2.576 -0.019
ENSG00000121152 E024 0.6695470 0.0180526496 2.301886e-01 3.626822e-01 2 96364480 96364480 1 + 0.112 0.319 1.884
ENSG00000121152 E025 432.0479998 0.0007452930 2.661857e-01 4.043531e-01 2 96364481 96364591 111 + 2.625 2.653 0.092
ENSG00000121152 E026 435.6015821 0.0002028100 7.099888e-02 1.449972e-01 2 96365876 96365968 93 + 2.624 2.659 0.118
ENSG00000121152 E027 470.1932906 0.0003377022 3.564921e-03 1.191222e-02 2 96365969 96366058 90 + 2.645 2.701 0.184
ENSG00000121152 E028 425.3011819 0.0004891818 4.447881e-07 3.973769e-06 2 96367257 96367373 117 + 2.577 2.678 0.338
ENSG00000121152 E029 363.1719021 0.0001436345 4.733868e-17 2.116223e-15 2 96368972 96369063 92 + 2.476 2.638 0.540
ENSG00000121152 E030 347.3601501 0.0002079981 3.309908e-17 1.509877e-15 2 96369425 96369500 76 + 2.453 2.622 0.565
ENSG00000121152 E031 925.6339346 0.0035719366 4.883972e-03 1.560714e-02 2 96373292 96377091 3800 + 2.924 3.009 0.283