ENSG00000121067

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347630 ENSG00000121067 HEK293_OSMI2_2hA HEK293_TMG_2hB SPOP protein_coding protein_coding 26.72441 19.20174 35.54448 2.120415 0.1730847 0.8880433 0.4163514 1.241984 0.000000 0.4645574 0.0000000 -6.9680720 0.02133333 0.06133333 0.00000000 -0.06133333 4.314339e-12 2.228017e-21 FALSE TRUE
ENST00000504102 ENSG00000121067 HEK293_OSMI2_2hA HEK293_TMG_2hB SPOP protein_coding protein_coding 26.72441 19.20174 35.54448 2.120415 0.1730847 0.8880433 13.5361098 13.858013 16.189052 1.8388279 0.3051047 0.2241483 0.54276250 0.71983333 0.45556667 -0.26426667 2.712457e-05 2.228017e-21 FALSE TRUE
ENST00000505581 ENSG00000121067 HEK293_OSMI2_2hA HEK293_TMG_2hB SPOP protein_coding protein_coding 26.72441 19.20174 35.54448 2.120415 0.1730847 0.8880433 1.2211236 0.000000 3.367470 0.0000000 0.3472872 8.3997990 0.03282500 0.00000000 0.09483333 0.09483333 2.228017e-21 2.228017e-21 FALSE FALSE
MSTRG.14639.4 ENSG00000121067 HEK293_OSMI2_2hA HEK293_TMG_2hB SPOP protein_coding   26.72441 19.20174 35.54448 2.120415 0.1730847 0.8880433 6.4813404 1.656046 9.954228 0.6222336 0.8482276 2.5803296 0.21421250 0.08866667 0.27983333 0.19116667 1.489205e-02 2.228017e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121067 E001 0.1482932 0.0411597534 3.734053e-01   17 49598884 49598885 2 - 0.000 0.139 10.505
ENSG00000121067 E002 200.8684002 0.0031294001 4.889515e-12 1.071119e-10 17 49598886 49599496 611 - 2.164 2.429 0.886
ENSG00000121067 E003 140.2230865 0.0033219380 2.145247e-07 2.044216e-06 17 49599497 49599526 30 - 2.035 2.261 0.756
ENSG00000121067 E004 128.3510007 0.0029903558 1.870321e-05 1.167969e-04 17 49599527 49599546 20 - 2.019 2.207 0.629
ENSG00000121067 E005 170.5052134 0.0035565499 7.087995e-11 1.282643e-09 17 49599547 49599623 77 - 2.090 2.362 0.906
ENSG00000121067 E006 424.0186597 0.0018485565 1.761068e-05 1.105904e-04 17 49599624 49599989 366 - 2.571 2.690 0.399
ENSG00000121067 E007 101.5886422 0.0022166878 3.439264e-01 4.879841e-01 17 49599990 49600005 16 - 1.990 2.037 0.157
ENSG00000121067 E008 162.2112904 0.0002312107 3.811511e-01 5.254543e-01 17 49600006 49600088 83 - 2.199 2.235 0.121
ENSG00000121067 E009 100.1192255 0.0002760217 8.715582e-01 9.213758e-01 17 49600089 49600092 4 - 2.005 2.011 0.021
ENSG00000121067 E010 206.5710435 0.0001938086 2.220913e-01 3.529075e-01 17 49600093 49600202 110 - 2.300 2.342 0.139
ENSG00000121067 E011 196.1431705 0.0002369931 7.660507e-01 8.486603e-01 17 49600203 49600278 76 - 2.287 2.306 0.063
ENSG00000121067 E012 148.4049542 0.0002830696 1.156532e-01 2.137661e-01 17 49600279 49600308 30 - 2.193 2.158 -0.117
ENSG00000121067 E013 293.1573864 0.0001521438 2.468902e-01 3.822935e-01 17 49600309 49600522 214 - 2.478 2.467 -0.039
ENSG00000121067 E014 10.7038836 0.0015484864 3.250375e-02 7.681138e-02 17 49600523 49601631 1109 - 1.159 0.952 -0.754
ENSG00000121067 E015 3.9607859 0.0040249017 3.464793e-02 8.098238e-02 17 49601681 49601864 184 - 0.819 0.515 -1.299
ENSG00000121067 E016 244.5789683 0.0002063088 1.278532e-01 2.311881e-01 17 49601865 49602007 143 - 2.405 2.383 -0.075
ENSG00000121067 E017 5.6058560 0.0028821050 2.593144e-02 6.380568e-02 17 49602008 49602398 391 - 0.932 0.644 -1.146
ENSG00000121067 E018 1.5886424 0.0103370216 4.016523e-01 5.453438e-01 17 49607068 49607249 182 - 0.471 0.330 -0.783
ENSG00000121067 E019 228.1494662 0.0022265971 2.547869e-01 3.915682e-01 17 49607250 49607372 123 - 2.375 2.345 -0.099
ENSG00000121067 E020 146.5913814 0.0011638791 6.713168e-01 7.775771e-01 17 49607874 49607929 56 - 2.159 2.181 0.075
ENSG00000121067 E021 148.3323193 0.0009427740 6.056408e-01 7.259987e-01 17 49611280 49611337 58 - 2.180 2.173 -0.023
ENSG00000121067 E022 146.7508848 0.0002386749 1.072455e-01 2.014569e-01 17 49611338 49611380 43 - 2.189 2.153 -0.119
ENSG00000121067 E023 168.8401812 0.0002079045 9.482778e-05 4.976961e-04 17 49611381 49611457 77 - 2.275 2.179 -0.320
ENSG00000121067 E024 0.3268771 0.0301387073 8.366749e-01   17 49612779 49612941 163 - 0.107 0.140 0.440
ENSG00000121067 E025 0.5169874 0.0217681645 4.185880e-01 5.618395e-01 17 49618504 49618563 60 - 0.107 0.245 1.440
ENSG00000121067 E026 235.4087502 0.0001694369 6.386831e-08 6.736629e-07 17 49618981 49619108 128 - 2.427 2.314 -0.380
ENSG00000121067 E027 213.4282268 0.0007017260 1.048777e-05 6.940324e-05 17 49619234 49619318 85 - 2.383 2.276 -0.358
ENSG00000121067 E028 171.2595100 0.0006343828 6.954759e-03 2.110660e-02 17 49619319 49619385 67 - 2.271 2.204 -0.225
ENSG00000121067 E029 0.1482932 0.0411597534 3.734053e-01   17 49620621 49620670 50 - 0.000 0.139 10.528
ENSG00000121067 E030 166.3547272 0.0026616976 2.852382e-02 6.906460e-02 17 49621946 49622024 79 - 2.258 2.186 -0.241
ENSG00000121067 E031 107.3946909 0.0003278314 2.432972e-03 8.560906e-03 17 49622025 49622049 25 - 2.080 1.988 -0.311
ENSG00000121067 E032 86.7991567 0.0046687630 1.978750e-03 7.160669e-03 17 49622050 49622067 18 - 2.009 1.861 -0.499
ENSG00000121067 E033 0.5964967 0.0212581617 4.599368e-01 6.000034e-01 17 49622206 49622283 78 - 0.264 0.139 -1.148
ENSG00000121067 E034 0.8995276 0.2375504763 2.758410e-01 4.152278e-01 17 49622414 49622732 319 - 0.381 0.138 -1.908
ENSG00000121067 E035 170.1918350 0.0080543493 1.065784e-02 3.035140e-02 17 49622733 49622876 144 - 2.289 2.160 -0.434
ENSG00000121067 E036 0.0000000       17 49636197 49636313 117 -      
ENSG00000121067 E037 13.8749765 0.0013093592 1.153715e-01 2.133951e-01 17 49636759 49636809 51 - 1.236 1.105 -0.465
ENSG00000121067 E038 0.1472490 0.0431599561 6.440821e-01   17 49646116 49646630 515 - 0.107 0.000 -9.928
ENSG00000121067 E039 0.0000000       17 49646926 49647122 197 -      
ENSG00000121067 E040 8.4706744 0.0020351332 3.000159e-03 1.026530e-02 17 49668027 49668078 52 - 1.105 0.773 -1.253
ENSG00000121067 E041 14.2986061 0.0012733085 8.963209e-01 9.377246e-01 17 49675895 49676016 122 - 1.175 1.198 0.081
ENSG00000121067 E042 107.1094685 0.0023374944 5.373803e-04 2.299797e-03 17 49677933 49678163 231 - 2.093 1.960 -0.446