ENSG00000121057

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314126 ENSG00000121057 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP1 protein_coding protein_coding 59.3567 57.54126 52.75895 3.390834 1.663535 -0.1251581 1.694852 0.000000 2.844257 0.00000000 0.6511368 8.1569712 0.02840417 0.000000000 0.05330000 0.05330000 4.265288e-18 1.185319e-44 TRUE TRUE
ENST00000337714 ENSG00000121057 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP1 protein_coding protein_coding 59.3567 57.54126 52.75895 3.390834 1.663535 -0.1251581 33.914415 21.798093 42.682070 3.43312820 0.7081443 0.9691045 0.57695417 0.383066667 0.81083333 0.42776667 1.765597e-05 1.185319e-44 FALSE TRUE
ENST00000572557 ENSG00000121057 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP1 protein_coding protein_coding 59.3567 57.54126 52.75895 3.390834 1.663535 -0.1251581 12.120253 18.451311 0.000000 2.53885806 0.0000000 -10.8502893 0.20077083 0.319766667 0.00000000 -0.31976667 1.185319e-44 1.185319e-44 FALSE TRUE
ENST00000573326 ENSG00000121057 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP1 protein_coding nonsense_mediated_decay 59.3567 57.54126 52.75895 3.390834 1.663535 -0.1251581 4.972716 10.953937 1.198802 2.33129110 0.7501312 -3.1811165 0.08350833 0.187400000 0.02293333 -0.16446667 1.389149e-01 1.185319e-44 TRUE TRUE
MSTRG.14725.2 ENSG00000121057 HEK293_OSMI2_2hA HEK293_TMG_2hB AKAP1 protein_coding   59.3567 57.54126 52.75895 3.390834 1.663535 -0.1251581 2.165514 0.176435 3.144403 0.08835945 0.9414112 4.0806225 0.03637083 0.003266667 0.05933333 0.05606667 6.063268e-03 1.185319e-44 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121057 E001 0.5202097 0.0198509337 5.100100e-01 6.452681e-01 17 57085092 57085158 67 + 0.224 0.119 -1.102
ENSG00000121057 E002 1.8414119 0.0079846668 1.169402e-03 4.537144e-03 17 57085205 57085228 24 + 0.673 0.119 -3.563
ENSG00000121057 E003 2.7250198 0.0090976268 2.085857e-05 1.288359e-04 17 57085229 57085245 17 + 0.828 0.119 -4.190
ENSG00000121057 E004 76.8889121 0.0186901309 2.779289e-10 4.548444e-09 17 57085246 57085398 153 + 2.096 1.605 -1.656
ENSG00000121057 E005 0.0000000       17 57085714 57085716 3 +      
ENSG00000121057 E006 0.0000000       17 57085717 57085755 39 +      
ENSG00000121057 E007 0.0000000       17 57085756 57085773 18 +      
ENSG00000121057 E008 0.3299976 0.0274424043 2.301610e-01   17 57085774 57085866 93 + 0.000 0.211 12.872
ENSG00000121057 E009 0.3299976 0.0274424043 2.301610e-01   17 57085867 57085869 3 + 0.000 0.211 12.872
ENSG00000121057 E010 0.9921577 0.0126399445 4.937744e-01 6.307887e-01 17 57085870 57086074 205 + 0.224 0.353 0.895
ENSG00000121057 E011 0.5879639 0.0204144946 2.663819e-01 4.045648e-01 17 57086259 57086372 114 + 0.304 0.118 -1.691
ENSG00000121057 E012 3.3494377 0.0813915252 3.316309e-01 4.752776e-01 17 57086373 57086537 165 + 0.731 0.576 -0.663
ENSG00000121057 E013 0.4772466 0.0204479810 6.320368e-01 7.469633e-01 17 57095844 57095959 116 + 0.126 0.211 0.895
ENSG00000121057 E014 0.3666179 0.0263840951 9.414049e-01 9.671614e-01 17 57096536 57096577 42 + 0.126 0.119 -0.101
ENSG00000121057 E015 0.2214452 0.0403345876 5.296949e-01   17 57096578 57096590 13 + 0.000 0.119 11.878
ENSG00000121057 E016 0.2214452 0.0403345876 5.296949e-01   17 57096591 57096608 18 + 0.000 0.119 11.878
ENSG00000121057 E017 0.7331471 0.0157971689 4.667591e-02 1.032521e-01 17 57096609 57096725 117 + 0.000 0.353 13.874
ENSG00000121057 E018 0.5117019 0.0249671417 1.020580e-01 1.936479e-01 17 57096726 57096763 38 + 0.000 0.288 13.457
ENSG00000121057 E019 0.4031496 0.0253236537 2.273655e-01 3.592499e-01 17 57098437 57098574 138 + 0.000 0.212 12.877
ENSG00000121057 E020 0.0000000       17 57101594 57101730 137 +      
ENSG00000121057 E021 502.6757463 0.0031598223 1.228903e-09 1.789911e-08 17 57105441 57105876 436 + 2.789 2.613 -0.586
ENSG00000121057 E022 377.7027430 0.0003363869 4.958736e-09 6.477402e-08 17 57105877 57106022 146 + 2.629 2.528 -0.336
ENSG00000121057 E023 182.9038428 0.0030432764 7.160202e-03 2.163892e-02 17 57106023 57106023 1 + 2.308 2.220 -0.295
ENSG00000121057 E024 721.6335939 0.0012200942 7.861089e-06 5.348968e-05 17 57106024 57106410 387 + 2.899 2.820 -0.262
ENSG00000121057 E025 604.6452317 0.0006594563 1.177288e-02 3.298924e-02 17 57106411 57106718 308 + 2.798 2.766 -0.108
ENSG00000121057 E026 759.5594052 0.0003031583 1.997161e-03 7.217018e-03 17 57106719 57107124 406 + 2.896 2.865 -0.103
ENSG00000121057 E027 315.3230259 0.0001845891 1.136899e-01 2.109046e-01 17 57107125 57107178 54 + 2.507 2.490 -0.058
ENSG00000121057 E028 33.2999012 0.0006281954 1.992623e-02 5.133214e-02 17 57107946 57108048 103 + 1.596 1.471 -0.429
ENSG00000121057 E029 454.6265590 0.0001142955 7.660959e-01 8.486806e-01 17 57110025 57110158 134 + 2.651 2.662 0.034
ENSG00000121057 E030 459.8845069 0.0001573398 6.880220e-02 1.413875e-01 17 57111798 57111924 127 + 2.671 2.655 -0.053
ENSG00000121057 E031 458.4045573 0.0013026264 3.893269e-01 5.334376e-01 17 57112491 57112618 128 + 2.664 2.658 -0.020
ENSG00000121057 E032 219.7604468 0.0028033521 3.744359e-01 5.188480e-01 17 57114459 57114488 30 + 2.352 2.335 -0.057
ENSG00000121057 E033 486.6326892 0.0008944764 1.885375e-01 3.118977e-01 17 57114489 57114636 148 + 2.662 2.705 0.141
ENSG00000121057 E034 226.5816295 0.0001759556 5.967422e-02 1.260633e-01 17 57116111 57116132 22 + 2.320 2.381 0.202
ENSG00000121057 E035 495.2243456 0.0001213431 1.476172e-02 3.995376e-02 17 57116133 57116261 129 + 2.662 2.717 0.183
ENSG00000121057 E036 378.3446131 0.0001427293 1.959105e-01 3.211131e-01 17 57116860 57116927 68 + 2.555 2.595 0.131
ENSG00000121057 E037 439.2318685 0.0001360267 3.980739e-01 5.418172e-01 17 57118381 57118454 74 + 2.626 2.656 0.100
ENSG00000121057 E038 393.2655274 0.0001405326 1.158693e-01 2.140463e-01 17 57118982 57119044 63 + 2.569 2.613 0.147
ENSG00000121057 E039 337.5538666 0.0002297507 4.564024e-03 1.472158e-02 17 57120250 57120293 44 + 2.485 2.558 0.242
ENSG00000121057 E040 1593.6327665 0.0030674553 2.689876e-13 7.197583e-12 17 57120294 57121278 985 + 3.079 3.274 0.650
ENSG00000121057 E041 26.1965422 0.0007370081 3.857856e-02 8.841324e-02 17 57121279 57121310 32 + 1.341 1.497 0.541
ENSG00000121057 E042 5.4004947 0.0030301345 3.323010e-03 1.121465e-02 17 57121311 57121346 36 + 0.527 0.947 1.732
ENSG00000121057 E043 2.6831234 0.0062155675 6.454501e-01 7.575463e-01 17 57121525 57121587 63 + 0.606 0.545 -0.275
ENSG00000121057 E044 2.3926643 0.0279510064 9.635572e-01 9.810343e-01 17 57123186 57123294 109 + 0.527 0.544 0.084