ENSG00000121005

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262207 ENSG00000121005 HEK293_OSMI2_2hA HEK293_TMG_2hB CRISPLD1 protein_coding protein_coding 4.389469 1.132756 7.9203 0.1195557 0.693802 2.794858 3.240280 1.132756 5.377318 0.1195557 0.06355026 2.237050 0.8598042 1 0.6877333 -0.3122667 3.491746e-07 3.482996e-07 FALSE TRUE
ENST00000520277 ENSG00000121005 HEK293_OSMI2_2hA HEK293_TMG_2hB CRISPLD1 protein_coding protein_coding 4.389469 1.132756 7.9203 0.1195557 0.693802 2.794858 1.060496 0.000000 2.317467 0.0000000 0.55889612 7.862617 0.1294792 0 0.2851667 0.2851667 3.482996e-07 3.482996e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000121005 E001 7.174921 0.0023219562 9.447144e-01 9.693040e-01 8 74984505 74984601 97 + 0.832 0.826 -0.025
ENSG00000121005 E002 7.842471 0.0020969007 4.257758e-02 9.577643e-02 8 74984602 74984627 26 + 0.910 0.585 -1.324
ENSG00000121005 E003 18.643640 0.0009608035 6.476451e-03 1.986214e-02 8 74984628 74984752 125 + 1.250 0.946 -1.100
ENSG00000121005 E004 26.464550 0.0007613258 1.769615e-02 4.647962e-02 8 74984753 74984869 117 + 1.378 1.163 -0.758
ENSG00000121005 E005 18.903778 0.0010290957 1.111664e-01 2.072603e-01 8 74984870 74984920 51 + 1.232 1.068 -0.587
ENSG00000121005 E006 45.757631 0.0035889040 7.154156e-02 1.459011e-01 8 74985926 74986117 192 + 1.598 1.470 -0.437
ENSG00000121005 E007 43.614639 0.0005677122 7.440356e-02 1.505788e-01 8 74986118 74986245 128 + 1.578 1.459 -0.408
ENSG00000121005 E008 0.000000       8 75000154 75000173 20 +      
ENSG00000121005 E009 0.000000       8 75000174 75000409 236 +      
ENSG00000121005 E010 34.615143 0.0006361671 5.401350e-02 1.162872e-01 8 75012433 75012551 119 + 1.483 1.336 -0.510
ENSG00000121005 E011 31.222434 0.0006600637 5.103962e-01 6.456182e-01 8 75012890 75013022 133 + 1.424 1.377 -0.165
ENSG00000121005 E012 36.663295 0.0006298094 9.440412e-01 9.689336e-01 8 75013987 75014102 116 + 1.481 1.480 -0.004
ENSG00000121005 E013 33.086123 0.0093793859 1.559819e-01 2.697722e-01 8 75014812 75014912 101 + 1.462 1.336 -0.435
ENSG00000121005 E014 43.957232 0.0005714439 2.742528e-01 4.133824e-01 8 75016565 75016705 141 + 1.570 1.500 -0.238
ENSG00000121005 E015 29.288890 0.0008663414 4.346041e-01 5.769273e-01 8 75016881 75016941 61 + 1.373 1.437 0.222
ENSG00000121005 E016 28.757267 0.0081375886 5.534183e-01 6.825744e-01 8 75017047 75017113 67 + 1.370 1.425 0.191
ENSG00000121005 E017 37.252553 0.0006019469 2.465350e-01 3.818976e-01 8 75017320 75017450 131 + 1.473 1.555 0.283
ENSG00000121005 E018 25.746870 0.0011321685 8.783095e-01 9.258515e-01 8 75019870 75019913 44 + 1.333 1.350 0.059
ENSG00000121005 E019 32.500065 0.0007144416 8.921669e-01 9.351153e-01 8 75020007 75020079 73 + 1.432 1.426 -0.020
ENSG00000121005 E020 38.058014 0.0006726340 9.987359e-01 1.000000e+00 8 75025546 75025621 76 + 1.496 1.500 0.015
ENSG00000121005 E021 43.973710 0.0005333876 5.718632e-01 6.980824e-01 8 75029387 75029517 131 + 1.548 1.588 0.137
ENSG00000121005 E022 128.889009 0.0013147305 1.179036e-09 1.723095e-08 8 75032191 75034558 2368 + 1.965 2.182 0.726