ENSG00000120992

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316963 ENSG00000120992 HEK293_OSMI2_2hA HEK293_TMG_2hB LYPLA1 protein_coding protein_coding 51.00078 15.92807 93.74144 4.164049 3.331661 2.556364 32.359590 13.9815877 61.280135 3.01961327 2.8453190 2.131095 0.68627500 0.896333333 0.6532667 -0.24306667 2.132032e-03 5.764604e-18 FALSE TRUE
ENST00000520718 ENSG00000120992 HEK293_OSMI2_2hA HEK293_TMG_2hB LYPLA1 protein_coding processed_transcript 51.00078 15.92807 93.74144 4.164049 3.331661 2.556364 3.121513 0.1269748 4.829315 0.07423531 0.7225023 5.142820 0.08007500 0.008266667 0.0517000 0.04343333 4.519013e-03 5.764604e-18   FALSE
MSTRG.31514.8 ENSG00000120992 HEK293_OSMI2_2hA HEK293_TMG_2hB LYPLA1 protein_coding   51.00078 15.92807 93.74144 4.164049 3.331661 2.556364 6.831329 0.0000000 11.218254 0.00000000 1.8240172 10.132918 0.07599167 0.000000000 0.1187667 0.11876667 5.764604e-18 5.764604e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120992 E001 0.4448795 0.1017597914 4.569806e-03 1.473769e-02 8 54046367 54046367 1 - 0.000 0.511 14.717
ENSG00000120992 E002 1111.1117904 0.0046871634 4.324971e-16 1.711978e-14 8 54046368 54047406 1039 - 2.863 3.163 0.997
ENSG00000120992 E003 417.7842629 0.0025243096 1.692671e-03 6.259692e-03 8 54047407 54047791 385 - 2.477 2.639 0.541
ENSG00000120992 E004 359.3593870 0.0008915913 2.053519e-01 3.328653e-01 8 54047792 54047962 171 - 2.441 2.472 0.104
ENSG00000120992 E005 482.0710963 0.0001922072 5.988054e-05 3.308694e-04 8 54047963 54048118 156 - 2.577 2.561 -0.054
ENSG00000120992 E006 1.0415798 0.1393524592 2.836351e-01 4.237816e-01 8 54051011 54051011 1 - 0.296 0.000 -11.421
ENSG00000120992 E007 327.3210993 0.0002198234 8.600448e-04 3.473643e-03 8 54051012 54051071 60 - 2.409 2.392 -0.056
ENSG00000120992 E008 316.3475728 0.0001583504 9.462114e-03 2.744246e-02 8 54051072 54051124 53 - 2.391 2.393 0.010
ENSG00000120992 E009 219.8789100 0.0003987337 4.874147e-02 1.069298e-01 8 54051125 54051146 22 - 2.232 2.238 0.019
ENSG00000120992 E010 201.6046958 0.0006250613 1.213048e-02 3.384711e-02 8 54051147 54051188 42 - 2.199 2.181 -0.061
ENSG00000120992 E011 0.5933762 0.0224038798 5.558959e-01 6.846808e-01 8 54052654 54052654 1 - 0.192 0.000 -10.612
ENSG00000120992 E012 307.3360993 0.0001511132 8.954838e-07 7.511478e-06 8 54052655 54052741 87 - 2.390 2.327 -0.208
ENSG00000120992 E013 168.0296202 0.0002018480 1.908037e-03 6.940973e-03 8 54052742 54052756 15 - 2.126 2.083 -0.142
ENSG00000120992 E014 7.6114609 0.0021545866 4.374166e-02 9.791692e-02 8 54052757 54052898 142 - 0.877 0.607 -1.104
ENSG00000120992 E015 14.0737342 0.0163734335 4.359264e-03 1.414610e-02 8 54053198 54053668 471 - 1.122 0.746 -1.423
ENSG00000120992 E016 15.7162003 0.0010988970 8.540997e-02 1.680699e-01 8 54054453 54055059 607 - 1.140 1.006 -0.488
ENSG00000120992 E017 239.0337176 0.0001682875 2.285513e-05 1.397758e-04 8 54055060 54055101 42 - 2.281 2.222 -0.197
ENSG00000120992 E018 211.6818308 0.0001953578 1.164570e-05 7.622451e-05 8 54055102 54055133 32 - 2.231 2.158 -0.244
ENSG00000120992 E019 258.8089324 0.0001932457 6.497961e-06 4.507742e-05 8 54062254 54062324 71 - 2.317 2.254 -0.208
ENSG00000120992 E020 197.6949318 0.0010997084 4.958795e-04 2.144129e-03 8 54063328 54063375 48 - 2.199 2.143 -0.189
ENSG00000120992 E021 6.2676789 0.0795377855 8.027998e-01 8.744149e-01 8 54065333 54065450 118 - 0.768 0.794 0.105
ENSG00000120992 E022 196.8857812 0.0018891736 2.914375e-04 1.344927e-03 8 54065748 54065813 66 - 2.199 2.119 -0.269
ENSG00000120992 E023 3.7018786 0.0042812039 4.328546e-01 5.753144e-01 8 54080253 54080329 77 - 0.609 0.516 -0.424
ENSG00000120992 E024 1.2084086 0.0144324778 7.248725e-01 8.182735e-01 8 54100224 54100347 124 - 0.295 0.246 -0.355
ENSG00000120992 E025 2.0972133 0.0120226769 7.355747e-01 8.263161e-01 8 54100350 54100907 558 - 0.426 0.402 -0.134
ENSG00000120992 E026 158.4907471 0.0059983156 1.281045e-01 2.315260e-01 8 54100908 54100939 32 - 2.097 2.072 -0.083
ENSG00000120992 E027 6.1387431 0.0025937492 1.542919e-01 2.674890e-01 8 54101350 54101754 405 - 0.789 0.607 -0.759
ENSG00000120992 E028 174.1074778 0.0074205162 6.352437e-02 1.325663e-01 8 54101755 54102017 263 - 2.141 2.095 -0.153
ENSG00000120992 E029 0.4418608 0.0257239617 8.665148e-01 9.180630e-01 8 54102033 54102106 74 - 0.151 0.000 -10.196