ENSG00000120963

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000517844 ENSG00000120963 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF706 protein_coding protein_coding 48.23922 56.20519 42.30114 1.387061 1.944925 -0.4099224 28.142630 35.10002 20.693900 1.3404206 2.4838159 -0.7619805 0.5777458 0.6244000 0.4857333 -0.13866667 0.04878557 5.121714e-05   FALSE
MSTRG.31929.2 ENSG00000120963 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF706 protein_coding   48.23922 56.20519 42.30114 1.387061 1.944925 -0.4099224 9.902867 11.69368 9.959397 0.6482362 0.9221732 -0.2313846 0.2061833 0.2077667 0.2383000 0.03053333 0.76529012 5.121714e-05 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120963 E001 2.5974895 0.1877017908 5.795060e-02 1.231223e-01 8 101177878 101177994 117 - 0.783 0.318 -2.229
ENSG00000120963 E002 1.5332094 0.2829957786 1.020836e-01 1.936772e-01 8 101177995 101177996 2 - 0.614 0.189 -2.514
ENSG00000120963 E003 6.1682492 0.1077747250 2.266897e-03 8.051009e-03 8 101177997 101178387 391 - 1.129 0.530 -2.384
ENSG00000120963 E004 89.9197416 0.0306720561 9.168199e-05 4.828981e-04 8 101197052 101198725 1674 - 2.131 1.787 -1.154
ENSG00000120963 E005 17.3540554 0.0028776656 1.192031e-04 6.102322e-04 8 101198726 101198923 198 - 1.435 1.110 -1.140
ENSG00000120963 E006 7.3489649 0.0027706298 3.232844e-01 4.665915e-01 8 101198924 101198932 9 - 0.982 0.859 -0.466
ENSG00000120963 E007 7.1264730 0.0028364598 7.221566e-01 8.163447e-01 8 101198933 101198936 4 - 0.926 0.875 -0.193
ENSG00000120963 E008 7.5619024 0.0038593195 7.870788e-01 8.636657e-01 8 101198937 101198937 1 - 0.946 0.905 -0.152
ENSG00000120963 E009 7.7134179 0.0066090364 6.720778e-01 7.781731e-01 8 101198938 101198938 1 - 0.964 0.905 -0.223
ENSG00000120963 E010 286.9484979 0.0002000124 3.811382e-06 2.786458e-05 8 101198939 101199159 221 - 2.387 2.477 0.300
ENSG00000120963 E011 247.8098243 0.0001963575 5.948824e-04 2.514529e-03 8 101199160 101199194 35 - 2.335 2.405 0.232
ENSG00000120963 E012 278.5964110 0.0002027176 1.616983e-02 4.309809e-02 8 101199195 101199239 45 - 2.404 2.447 0.142
ENSG00000120963 E013 344.5418291 0.0001400849 3.898795e-03 1.285979e-02 8 101199990 101200035 46 - 2.495 2.540 0.152
ENSG00000120963 E014 400.5813242 0.0001443473 3.278227e-01 4.712959e-01 8 101200036 101200097 62 - 2.584 2.592 0.026
ENSG00000120963 E015 4.0005493 0.0042778510 1.490273e-01 2.603586e-01 8 101200098 101200123 26 - 0.811 0.600 -0.879
ENSG00000120963 E016 3.1367288 0.0469311450 1.252201e-03 4.816864e-03 8 101200124 101200288 165 - 0.883 0.317 -2.628
ENSG00000120963 E017 4.4060819 0.0243542600 3.215996e-04 1.467250e-03 8 101200768 101201004 237 - 0.983 0.420 -2.401
ENSG00000120963 E018 4.1350017 0.0068737015 3.070900e-03 1.047483e-02 8 101201220 101201606 387 - 0.926 0.500 -1.780
ENSG00000120963 E019 248.5690551 0.0001846403 7.983724e-01 8.713168e-01 8 101201607 101201614 8 - 2.392 2.377 -0.051
ENSG00000120963 E020 418.7038300 0.0001428924 5.820981e-01 7.065172e-01 8 101201615 101201715 101 - 2.608 2.608 -0.001
ENSG00000120963 E021 252.8683552 0.0001825140 6.810030e-01 7.848282e-01 8 101201716 101201743 28 - 2.391 2.390 -0.001
ENSG00000120963 E022 15.7945483 0.0011752850 2.080388e-01 3.361278e-01 8 101202333 101202447 115 - 1.279 1.163 -0.410
ENSG00000120963 E023 2.9204763 0.0052210750 2.361318e-01 3.696941e-01 8 101202448 101202452 5 - 0.691 0.501 -0.852
ENSG00000120963 E024 32.4350699 0.0006258196 4.658305e-17 2.085800e-15 8 101202453 101204649 2197 - 1.767 1.243 -1.800
ENSG00000120963 E025 6.3782229 0.1773458459 8.695534e-01 9.201459e-01 8 101204650 101204693 44 - 0.926 0.807 -0.459
ENSG00000120963 E026 3.8310495 0.0610777435 4.164395e-01 5.597924e-01 8 101204694 101204779 86 - 0.756 0.603 -0.644
ENSG00000120963 E027 6.9491288 0.0024063529 1.297735e-03 4.969117e-03 8 101204780 101205210 431 - 1.091 0.704 -1.482
ENSG00000120963 E028 1.9573486 0.0073369223 5.544645e-01 6.834465e-01 8 101205211 101205329 119 - 0.525 0.419 -0.530
ENSG00000120963 E029 284.8341623 0.0003116016 9.977877e-02 1.901440e-01 8 101205435 101205732 298 - 2.469 2.424 -0.151
ENSG00000120963 E030 0.2965864 0.0991307457 3.374424e-01   8 101205854 101206193 340 - 0.000 0.186 9.611