ENSG00000120942

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376804 ENSG00000120942 HEK293_OSMI2_2hA HEK293_TMG_2hB UBIAD1 protein_coding protein_coding 28.52997 35.74828 25.8244 1.151258 0.6842121 -0.4689836 1.550638 1.313956 1.836753 0.3046005 0.1793781 0.4801352 0.0561125 0.03656667 0.0715 0.03493333 1.304706e-01 2.473769e-10 FALSE TRUE
ENST00000376810 ENSG00000120942 HEK293_OSMI2_2hA HEK293_TMG_2hB UBIAD1 protein_coding protein_coding 28.52997 35.74828 25.8244 1.151258 0.6842121 -0.4689836 24.524845 33.045739 20.587812 1.1603200 0.2729643 -0.6824097 0.8538042 0.92426667 0.7978 -0.12646667 2.473769e-10 2.473769e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120942 E001 239.7374951 0.0030669848 2.105016e-01 3.391293e-01 1 11273198 11273527 330 + 2.365 2.352 -0.041
ENSG00000120942 E002 579.2165779 0.0010701783 9.752137e-01 9.885617e-01 1 11273528 11273888 361 + 2.717 2.749 0.104
ENSG00000120942 E003 268.3370877 0.0033841836 6.248154e-01 7.410564e-01 1 11273889 11273933 45 + 2.372 2.420 0.160
ENSG00000120942 E004 406.9477655 0.0013004405 9.833775e-01 9.936843e-01 1 11273934 11274060 127 + 2.564 2.595 0.103
ENSG00000120942 E005 359.6587883 0.0014743554 8.595132e-01 9.133759e-01 1 11285644 11285732 89 + 2.509 2.544 0.116
ENSG00000120942 E006 1954.1928549 0.0032787660 4.236572e-02 9.538707e-02 1 11285733 11288434 2702 + 3.224 3.288 0.212
ENSG00000120942 E007 0.7696683 0.0161174328 2.957166e-01 4.368645e-01 1 11292049 11292147 99 + 0.350 0.180 -1.276
ENSG00000120942 E008 9.1204355 0.0018992047 1.108094e-04 5.715857e-04 1 11293467 11293626 160 + 1.201 0.822 -1.401
ENSG00000120942 E009 1.3412721 0.1052589466 5.024904e-01 6.385475e-01 1 11293721 11293838 118 + 0.424 0.307 -0.689
ENSG00000120942 E010 119.2915301 0.0004185794 2.490955e-36 6.600056e-34 1 11294873 11296049 1177 + 2.270 1.888 -1.278