ENSG00000120925

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319073 ENSG00000120925 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF170 protein_coding protein_coding 6.790652 2.558872 9.602769 0.3525411 0.2123533 1.903817 0.3350823 0.2220899 0.4914186 0.11737823 0.1677122 1.111332 0.05025417 0.08056667 0.05170000 -0.02886667 0.84793931 0.01464659 TRUE  
ENST00000527424 ENSG00000120925 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF170 protein_coding protein_coding 6.790652 2.558872 9.602769 0.3525411 0.2123533 1.903817 2.9349522 1.0661333 4.7838898 0.10183971 0.1450743 2.155340 0.45400000 0.42153333 0.49926667 0.07773333 0.45161840 0.01464659 FALSE  
ENST00000534961 ENSG00000120925 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF170 protein_coding protein_coding 6.790652 2.558872 9.602769 0.3525411 0.2123533 1.903817 0.3286751 0.1282111 0.2607756 0.07448944 0.1192177 0.970224 0.06940833 0.05246667 0.02666667 -0.02580000 0.84157196 0.01464659 FALSE  
ENST00000583919 ENSG00000120925 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF170 protein_coding miRNA 6.790652 2.558872 9.602769 0.3525411 0.2123533 1.903817 0.2268764 0.2318935 0.0000000 0.11799822 0.0000000 -4.596300 0.05044167 0.08556667 0.00000000 -0.08556667 0.01464659 0.01464659    
MSTRG.31460.7 ENSG00000120925 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF170 protein_coding   6.790652 2.558872 9.602769 0.3525411 0.2123533 1.903817 2.4252277 0.6555892 3.3670284 0.07707627 0.4604383 2.343050 0.27452083 0.25753333 0.34926667 0.09173333 0.39701488 0.01464659 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120925 E001 5.4558180 0.1249632905 0.0005193204 0.002232188 8 42849637 42850997 1361 - 0.484 1.153 2.693
ENSG00000120925 E002 0.0000000       8 42853297 42853300 4 -      
ENSG00000120925 E003 168.1016739 0.0028640356 0.7417870563 0.830826588 8 42853301 42855247 1947 - 2.168 2.168 0.000
ENSG00000120925 E004 32.0403621 0.0013254373 0.0290496216 0.070102078 8 42855248 42855706 459 - 1.489 1.332 -0.543
ENSG00000120925 E005 4.4996435 0.0150064253 0.4137415947 0.557158015 8 42855707 42855708 2 - 0.645 0.777 0.545
ENSG00000120925 E006 20.7164263 0.0241755722 0.0015384275 0.005761029 8 42855709 42855998 290 - 1.166 1.492 1.137
ENSG00000120925 E007 26.1851729 0.0009457316 0.0537680387 0.115845667 8 42855999 42856042 44 - 1.329 1.480 0.522
ENSG00000120925 E008 83.5876126 0.0003774917 0.2611244489 0.398752567 8 42856043 42856428 386 - 1.852 1.909 0.190
ENSG00000120925 E009 1.3392975 0.3785487396 0.8341633375 0.896139623 8 42861330 42861744 415 - 0.307 0.361 0.337
ENSG00000120925 E010 47.8022117 0.0011789148 0.4971828661 0.633728520 8 42861745 42861855 111 - 1.638 1.609 -0.099
ENSG00000120925 E011 28.8200791 0.0008975610 0.0593267088 0.125485865 8 42865416 42865465 50 - 1.444 1.306 -0.478
ENSG00000120925 E012 20.1136342 0.0009580063 0.0302527391 0.072462679 8 42865466 42865489 24 - 1.303 1.107 -0.697
ENSG00000120925 E013 37.7930510 0.0008242161 0.1896347319 0.313288490 8 42870004 42870112 109 - 1.548 1.470 -0.265
ENSG00000120925 E014 30.4023766 0.0006989860 0.1116474653 0.207975117 8 42873931 42874006 76 - 1.465 1.356 -0.375
ENSG00000120925 E015 36.1500778 0.0028516546 0.5543302410 0.683325810 8 42887728 42887848 121 - 1.501 1.552 0.174
ENSG00000120925 E016 24.3870494 0.0008676165 0.3119398359 0.454455779 8 42887849 42887871 23 - 1.365 1.292 -0.254
ENSG00000120925 E017 2.0974408 0.2774167669 0.7105718305 0.807716826 8 42889303 42889414 112 - 0.483 0.348 -0.735
ENSG00000120925 E018 0.5514428 0.0202462226 0.0049460311 0.015780968 8 42896197 42896253 57 - 0.000 0.457 12.362
ENSG00000120925 E019 3.5513016 0.0045116183 0.0158830568 0.042475966 8 42896254 42896483 230 - 0.484 0.858 1.599
ENSG00000120925 E020 22.6514425 0.0219068140 0.4202858808 0.563483431 8 42896484 42896723 240 - 1.335 1.249 -0.303
ENSG00000120925 E021 1.3745841 0.0250883892 0.4495270663 0.590724006 8 42897240 42897300 61 - 0.306 0.456 0.858