ENSG00000120868

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333991 ENSG00000120868 HEK293_OSMI2_2hA HEK293_TMG_2hB APAF1 protein_coding protein_coding 4.261404 2.156673 6.351691 0.224993 0.1173478 1.553929 0.05345438 0.2032244 0.0000000 0.20322439 0.0000000 -4.4143006 0.02726667 0.08320000 0.00000000 -0.08320000 5.566563e-01 2.12387e-24 FALSE TRUE
ENST00000357310 ENSG00000120868 HEK293_OSMI2_2hA HEK293_TMG_2hB APAF1 protein_coding protein_coding 4.261404 2.156673 6.351691 0.224993 0.1173478 1.553929 0.96036930 0.1595608 1.4544851 0.09502417 0.3789643 3.1105191 0.19725417 0.06646667 0.22703333 0.16056667 1.570639e-01 2.12387e-24 FALSE TRUE
ENST00000547666 ENSG00000120868 HEK293_OSMI2_2hA HEK293_TMG_2hB APAF1 protein_coding processed_transcript 4.261404 2.156673 6.351691 0.224993 0.1173478 1.553929 0.37414432 0.9761830 0.0000000 0.05030872 0.0000000 -6.6237834 0.16305417 0.46093333 0.00000000 -0.46093333 2.123870e-24 2.12387e-24   FALSE
ENST00000547743 ENSG00000120868 HEK293_OSMI2_2hA HEK293_TMG_2hB APAF1 protein_coding protein_coding 4.261404 2.156673 6.351691 0.224993 0.1173478 1.553929 0.05848247 0.0000000 0.3246134 0.00000000 0.1120453 5.0644231 0.01064583 0.00000000 0.05170000 0.05170000 1.685221e-02 2.12387e-24 FALSE TRUE
ENST00000550527 ENSG00000120868 HEK293_OSMI2_2hA HEK293_TMG_2hB APAF1 protein_coding protein_coding 4.261404 2.156673 6.351691 0.224993 0.1173478 1.553929 0.42109690 0.2050439 0.3775559 0.11129742 0.1907236 0.8497728 0.11491667 0.09746667 0.05863333 -0.03883333 8.952837e-01 2.12387e-24 FALSE TRUE
ENST00000551964 ENSG00000120868 HEK293_OSMI2_2hA HEK293_TMG_2hB APAF1 protein_coding protein_coding 4.261404 2.156673 6.351691 0.224993 0.1173478 1.553929 2.28455654 0.4949476 4.0747454 0.27236931 0.3238891 3.0160406 0.45889583 0.24143333 0.64380000 0.40236667 3.189698e-01 2.12387e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120868 E001 3.7114316 0.0047020125 4.119353e-03 1.347653e-02 12 98645290 98645299 10 + 0.669 0.000 -11.873
ENSG00000120868 E002 21.2262791 0.0008709505 6.089737e-02 1.281458e-01 12 98645300 98645670 371 + 1.280 1.098 -0.646
ENSG00000120868 E003 22.9642614 0.0008058090 7.052823e-02 1.442184e-01 12 98645671 98645835 165 + 1.312 1.146 -0.589
ENSG00000120868 E004 0.0000000       12 98648316 98648318 3 +      
ENSG00000120868 E005 13.5822540 0.0026778705 5.576911e-02 1.192955e-01 12 98648319 98648352 34 + 1.110 0.875 -0.874
ENSG00000120868 E006 11.8536357 0.0086759296 4.207250e-02 9.485991e-02 12 98648353 98648354 2 + 1.064 0.781 -1.068
ENSG00000120868 E007 12.4575073 0.0284997074 4.912161e-02 1.075894e-01 12 98648355 98648359 5 + 1.086 0.780 -1.151
ENSG00000120868 E008 25.8698554 0.0008733392 1.383272e-02 3.784677e-02 12 98648360 98648497 138 + 1.370 1.146 -0.791
ENSG00000120868 E009 27.5492314 0.0011502297 2.554706e-03 8.926640e-03 12 98648626 98648782 157 + 1.402 1.123 -0.982
ENSG00000120868 E010 14.4783422 0.0013373018 6.710427e-02 1.385473e-01 12 98648783 98648815 33 + 1.130 0.915 -0.791
ENSG00000120868 E011 0.5911862 0.0172671820 5.268950e-01 6.600734e-01 12 98648816 98648932 117 + 0.201 0.000 -11.964
ENSG00000120868 E012 32.1213415 0.0006443567 2.253953e-03 8.011346e-03 12 98649487 98649684 198 + 1.465 1.208 -0.896
ENSG00000120868 E013 25.8145470 0.0007942225 7.401404e-02 1.499395e-01 12 98659160 98659343 184 + 1.362 1.208 -0.540
ENSG00000120868 E014 17.6402420 0.0009904168 6.448783e-02 1.341970e-01 12 98662456 98662568 113 + 1.211 1.016 -0.704
ENSG00000120868 E015 18.7106279 0.0075645204 5.323398e-02 1.149033e-01 12 98662675 98662806 132 + 1.235 1.016 -0.784
ENSG00000120868 E016 28.4861110 0.0011691915 3.378949e-03 1.137628e-02 12 98665553 98665791 239 + 1.412 1.146 -0.934
ENSG00000120868 E017 26.2902239 0.0649128439 1.193950e-02 3.338651e-02 12 98666190 98666357 168 + 1.392 0.996 -1.407
ENSG00000120868 E018 24.5122137 0.0257469781 9.733964e-03 2.810868e-02 12 98667513 98667644 132 + 1.357 1.020 -1.199
ENSG00000120868 E019 0.4460135 0.0367000307 7.805733e-01 8.590024e-01 12 98670861 98670972 112 + 0.159 0.000 -11.441
ENSG00000120868 E020 22.1304325 0.0141626663 2.851153e-03 9.827025e-03 12 98670973 98671086 114 + 1.322 0.951 -1.332
ENSG00000120868 E021 27.2502035 0.0012558919 1.117477e-01 2.081270e-01 12 98671535 98671719 185 + 1.379 1.245 -0.465
ENSG00000120868 E022 22.2496819 0.0008241510 8.277398e-01 8.917217e-01 12 98677425 98677551 127 + 1.273 1.263 -0.037
ENSG00000120868 E023 28.2882397 0.0026515049 1.719506e-01 2.907387e-01 12 98680277 98680402 126 + 1.392 1.280 -0.390
ENSG00000120868 E024 28.3953761 0.0007417604 1.303634e-03 4.989082e-03 12 98683143 98683274 132 + 1.417 1.123 -1.034
ENSG00000120868 E025 28.5644096 0.0008882411 1.090088e-03 4.270347e-03 12 98686748 98686873 126 + 1.422 1.123 -1.051
ENSG00000120868 E026 27.2075874 0.0009763500 7.396756e-02 1.498613e-01 12 98699408 98699495 88 + 1.378 1.227 -0.529
ENSG00000120868 E027 23.5736906 0.0013704954 9.736286e-02 1.864441e-01 12 98699496 98699569 74 + 1.318 1.168 -0.531
ENSG00000120868 E028 19.9413209 0.0009422155 8.497758e-03 2.503226e-02 12 98703371 98703499 129 + 1.267 0.985 -1.013
ENSG00000120868 E029 32.0354163 0.0146174345 1.271391e-03 4.881663e-03 12 98706485 98706610 126 + 1.473 1.123 -1.226
ENSG00000120868 E030 25.2209798 0.0090740181 1.058161e-01 1.993300e-01 12 98708585 98708704 120 + 1.351 1.189 -0.568
ENSG00000120868 E031 27.1765302 0.0007490219 3.448508e-01 4.889455e-01 12 98712319 98712435 117 + 1.368 1.296 -0.251
ENSG00000120868 E032 0.7416694 0.0178138500 8.788386e-01 9.261642e-01 12 98712436 98712761 326 + 0.201 0.236 0.295
ENSG00000120868 E033 24.6487787 0.0007744800 9.277452e-01 9.585435e-01 12 98715427 98715552 126 + 1.309 1.326 0.060
ENSG00000120868 E034 22.4654978 0.0008950890 3.884714e-01 5.325465e-01 12 98723193 98723268 76 + 1.256 1.341 0.297
ENSG00000120868 E035 15.0764021 0.0037729809 6.313616e-02 1.319335e-01 12 98723269 98723312 44 + 1.063 1.263 0.712
ENSG00000120868 E036 29.0295341 0.0007708317 6.322759e-02 1.320866e-01 12 98723639 98723764 126 + 1.345 1.496 0.519
ENSG00000120868 E037 30.9789493 0.0036713703 3.387609e-01 4.826444e-01 12 98725415 98725540 126 + 1.389 1.475 0.297
ENSG00000120868 E038 17.2442307 0.0091520445 8.384583e-01 8.990192e-01 12 98727173 98727191 19 + 1.157 1.189 0.114
ENSG00000120868 E039 22.7882117 0.0008159171 7.474222e-01 8.349339e-01 12 98727192 98727278 87 + 1.273 1.311 0.133
ENSG00000120868 E040 16.1118575 0.0011189365 6.311686e-01 7.462492e-01 12 98727279 98727316 38 + 1.130 1.188 0.209
ENSG00000120868 E041 107.2019742 0.0002885147 1.042250e-02 2.980126e-02 12 98732420 98733647 1228 + 1.912 2.024 0.376
ENSG00000120868 E042 163.6283494 0.0004214208 8.857808e-24 8.566029e-22 12 98733648 98734845 1198 + 2.040 2.347 1.026
ENSG00000120868 E043 47.7670919 0.0102380195 1.778015e-06 1.398519e-05 12 98734846 98735020 175 + 1.499 1.855 1.209
ENSG00000120868 E044 44.3889311 0.0239975358 2.778183e-05 1.665143e-04 12 98735021 98735433 413 + 1.448 1.858 1.396