ENSG00000120805

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261636 ENSG00000120805 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL1 protein_coding protein_coding 40.07141 13.19604 72.56924 1.545376 2.659131 2.458359 11.177274 5.7949784 20.790882 1.0352842 0.6125947 1.841282 0.3084792 0.43370000 0.2867667 -0.14693333 0.0009573899 0.0009573899 FALSE TRUE
ENST00000539055 ENSG00000120805 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL1 protein_coding protein_coding 40.07141 13.19604 72.56924 1.545376 2.659131 2.458359 8.256261 3.0024295 14.533420 0.7029326 0.2511480 2.271367 0.2099000 0.22190000 0.2007333 -0.02116667 0.7732508514 0.0009573899 FALSE TRUE
ENST00000549283 ENSG00000120805 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL1 protein_coding processed_transcript 40.07141 13.19604 72.56924 1.545376 2.659131 2.458359 8.657284 0.9824958 22.761556 0.9824958 0.6634889 4.520028 0.1814458 0.08383333 0.3138333 0.23000000 0.1068167277 0.0009573899 FALSE FALSE
ENST00000551671 ENSG00000120805 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL1 protein_coding protein_coding 40.07141 13.19604 72.56924 1.545376 2.659131 2.458359 8.452213 2.9434531 9.886161 0.6342580 0.9830992 1.744466 0.2079667 0.22300000 0.1365667 -0.08643333 0.2894419458 0.0009573899 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120805 E001 518.3049224 0.0002308418 0.000982529 0.003900121 12 101393116 101394917 1802 - 2.646 2.704 0.193
ENSG00000120805 E002 72.5687609 0.0060870142 0.187874678 0.311064350 12 101394918 101394943 26 - 1.833 1.748 -0.286
ENSG00000120805 E003 302.1933068 0.0018646071 0.218059983 0.348079823 12 101394944 101395487 544 - 2.418 2.453 0.118
ENSG00000120805 E004 121.0692827 0.0010595627 0.261223194 0.398869369 12 101395488 101395506 19 - 2.023 2.069 0.155
ENSG00000120805 E005 195.3252041 0.0002168436 0.277413389 0.416975176 12 101395507 101395591 85 - 2.232 2.265 0.109
ENSG00000120805 E006 233.7094307 0.0002717859 0.061581513 0.129292308 12 101395592 101395670 79 - 2.304 2.355 0.169
ENSG00000120805 E007 3.7404972 0.0062040348 0.440585782 0.582264770 12 101396143 101396398 256 - 0.598 0.721 0.524
ENSG00000120805 E008 163.6067916 0.0002511688 0.293548227 0.434623623 12 101396399 101396413 15 - 2.154 2.188 0.114
ENSG00000120805 E009 328.3657033 0.0011506212 0.499071921 0.635413874 12 101396414 101396539 126 - 2.458 2.476 0.060
ENSG00000120805 E010 196.3850096 0.0012031322 0.347593968 0.491804345 12 101396540 101396577 38 - 2.232 2.261 0.098
ENSG00000120805 E011 0.6653823 0.0171392543 0.914796286 0.950050774 12 101400291 101400381 91 - 0.182 0.207 0.222
ENSG00000120805 E012 329.8877338 0.0001640326 0.000725393 0.002990393 12 101401062 101401173 112 - 2.482 2.406 -0.255
ENSG00000120805 E013 2.6593684 0.0054201172 0.220676118 0.351227201 12 101401174 101401486 313 - 0.578 0.346 -1.196
ENSG00000120805 E014 278.3532032 0.0003315725 0.002226165 0.007924322 12 101402865 101402946 82 - 2.410 2.332 -0.260
ENSG00000120805 E015 2.8108693 0.0055481826 0.558629526 0.686842078 12 101403142 101403255 114 - 0.558 0.451 -0.516
ENSG00000120805 E016 1.6942767 0.0580224548 0.298500113 0.439947338 12 101403416 101403699 284 - 0.438 0.207 -1.510
ENSG00000120805 E017 2.3270896 0.0063398745 0.335803070 0.479624275 12 101405656 101405843 188 - 0.438 0.606 0.804
ENSG00000120805 E018 203.0732127 0.0001951635 0.114515960 0.212137885 12 101405844 101405883 40 - 2.266 2.221 -0.150
ENSG00000120805 E019 245.8549351 0.0002875655 0.070159470 0.143631787 12 101405884 101405981 98 - 2.349 2.300 -0.162
ENSG00000120805 E020 1.9292386 0.0097508517 0.530981274 0.663488440 12 101407011 101407277 267 - 0.465 0.345 -0.656
ENSG00000120805 E021 1.4112044 0.0100962269 0.994893661 1.000000000 12 101407278 101407377 100 - 0.346 0.346 -0.002
ENSG00000120805 E022 3.2246426 0.0063019502 0.720042900 0.814718615 12 101407378 101407641 264 - 0.598 0.536 -0.283
ENSG00000120805 E023 161.2146372 0.0065825921 0.215515298 0.345035380 12 101407642 101407772 131 - 2.172 2.098 -0.250