ENSG00000120802

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266732 ENSG00000120802 HEK293_OSMI2_2hA HEK293_TMG_2hB TMPO protein_coding protein_coding 62.57475 26.98638 111.1642 4.444947 3.101871 2.041985 15.466822 7.539355 28.527629 1.40849847 0.5405362 1.918440 0.2359333 0.2777333 0.2567333 -0.0210000 4.859174e-01 2.907544e-17 FALSE TRUE
ENST00000548223 ENSG00000120802 HEK293_OSMI2_2hA HEK293_TMG_2hB TMPO protein_coding processed_transcript 62.57475 26.98638 111.1642 4.444947 3.101871 2.041985 3.844657 9.915430 1.676011 3.00297669 0.4388669 -2.557516 0.1437500 0.3520667 0.0149000 -0.3371667 2.907544e-17 2.907544e-17 FALSE TRUE
ENST00000556029 ENSG00000120802 HEK293_OSMI2_2hA HEK293_TMG_2hB TMPO protein_coding protein_coding 62.57475 26.98638 111.1642 4.444947 3.101871 2.041985 34.687983 7.512398 69.867244 0.06364789 1.8317234 3.215558 0.4719417 0.2934000 0.6287667 0.3353667 7.959697e-06 2.907544e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120802 E001 0.0000000       12 98512674 98513222 549 +      
ENSG00000120802 E002 5.1244724 0.0218835424 3.379301e-01 4.818087e-01 12 98513223 98515578 2356 + 0.697 0.622 -0.317
ENSG00000120802 E003 3.2612655 0.0047426718 5.575031e-03 1.748833e-02 12 98515579 98515589 11 + 0.593 0.000 -13.625
ENSG00000120802 E004 22.4771398 0.0010284469 6.478589e-07 5.603311e-06 12 98515590 98515617 28 + 1.300 0.819 -1.762
ENSG00000120802 E005 49.7934308 0.0024606540 2.539647e-04 1.191768e-03 12 98515618 98515629 12 + 1.603 1.461 -0.486
ENSG00000120802 E006 49.2127400 0.0010710470 2.048492e-04 9.847426e-04 12 98515630 98515630 1 + 1.598 1.462 -0.466
ENSG00000120802 E007 51.8938663 0.0020157175 1.210868e-04 6.189669e-04 12 98515631 98515631 1 + 1.622 1.473 -0.507
ENSG00000120802 E008 246.2580707 0.0005141063 4.546849e-12 1.000449e-10 12 98515632 98515785 154 + 2.281 2.184 -0.326
ENSG00000120802 E009 168.1589882 0.0025230348 6.710123e-04 2.792524e-03 12 98515786 98515814 29 + 2.107 2.084 -0.075
ENSG00000120802 E010 177.6238568 0.0084179812 1.255343e-02 3.485891e-02 12 98515815 98515851 37 + 2.129 2.106 -0.079
ENSG00000120802 E011 282.0915133 0.0080558045 4.443594e-03 1.438158e-02 12 98515852 98515963 112 + 2.330 2.301 -0.096
ENSG00000120802 E012 138.4718222 0.0033291573 9.150391e-03 2.665796e-02 12 98515964 98515970 7 + 2.019 2.017 -0.006
ENSG00000120802 E013 392.5963536 0.0106234011 1.553958e-05 9.881935e-05 12 98515971 98516146 176 + 2.487 2.361 -0.423
ENSG00000120802 E014 0.3030308 0.4125392255 1.000000e+00   12 98516252 98516517 266 + 0.103 0.000 -10.173
ENSG00000120802 E015 0.4407149 0.0212146083 5.142769e-01 6.489979e-01 12 98527529 98527884 356 + 0.102 0.255 1.588
ENSG00000120802 E016 0.5911862 0.0172671820 4.900571e-01 6.274108e-01 12 98527885 98527885 1 + 0.185 0.000 -11.165
ENSG00000120802 E017 489.2824439 0.0060389046 4.519835e-07 4.032348e-06 12 98527886 98528012 127 + 2.579 2.479 -0.336
ENSG00000120802 E018 0.2987644 0.0275511859 1.000000e+00   12 98528013 98528013 1 + 0.102 0.000 -10.166
ENSG00000120802 E019 627.1586150 0.0001666940 9.617340e-26 1.128858e-23 12 98531680 98531838 159 + 2.684 2.607 -0.254
ENSG00000120802 E020 4.4949407 0.0224178349 7.656508e-01 8.483513e-01 12 98531839 98532272 434 + 0.608 0.763 0.649
ENSG00000120802 E021 1314.3026594 0.0049777593 3.654327e-07 3.322302e-06 12 98532823 98535634 2812 + 2.927 3.223 0.984
ENSG00000120802 E022 411.9542923 0.0001279285 1.767125e-18 9.443628e-17 12 98537475 98537572 98 + 2.502 2.424 -0.263
ENSG00000120802 E023 7.4985749 0.0025760407 3.012147e-01 4.430004e-01 12 98537573 98537713 141 + 0.771 1.024 0.964
ENSG00000120802 E024 7.4939509 0.0028825949 2.257521e-03 8.022670e-03 12 98544202 98544229 28 + 0.867 0.414 -1.995
ENSG00000120802 E025 411.6376688 0.0001550096 1.350627e-17 6.524026e-16 12 98544230 98544349 120 + 2.502 2.427 -0.247
ENSG00000120802 E026 343.1236215 0.0001398736 3.590678e-21 2.629467e-19 12 98544442 98544537 96 + 2.430 2.307 -0.409
ENSG00000120802 E027 6.3046547 0.0027240719 1.117306e-01 2.080993e-01 12 98544639 98544950 312 + 0.781 0.623 -0.658
ENSG00000120802 E028 384.4372526 0.0002074811 2.131921e-14 6.682430e-13 12 98544951 98545061 111 + 2.470 2.410 -0.199
ENSG00000120802 E029 372.7688381 0.0006495148 9.682272e-09 1.197231e-07 12 98546359 98546447 89 + 2.451 2.425 -0.087
ENSG00000120802 E030 3170.3778406 0.0018159774 1.016630e-28 1.527339e-26 12 98547573 98550351 2779 + 3.311 3.600 0.960