ENSG00000120798

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330677 ENSG00000120798 HEK293_OSMI2_2hA HEK293_TMG_2hB NR2C1 protein_coding protein_coding 15.16563 5.39291 21.80552 1.41038 1.022685 2.013546 1.2552994 0.5346508 1.049466 0.11883437 0.08654003 0.9599336 0.09848333 0.10163333 0.047966667 -0.05366667 0.009641784 0.009641784 FALSE  
ENST00000333003 ENSG00000120798 HEK293_OSMI2_2hA HEK293_TMG_2hB NR2C1 protein_coding protein_coding 15.16563 5.39291 21.80552 1.41038 1.022685 2.013546 1.3382203 0.7004861 2.622248 0.11314209 0.10226415 1.8894171 0.09143333 0.13873333 0.121133333 -0.01760000 0.853947459 0.009641784 FALSE  
ENST00000393101 ENSG00000120798 HEK293_OSMI2_2hA HEK293_TMG_2hB NR2C1 protein_coding protein_coding 15.16563 5.39291 21.80552 1.41038 1.022685 2.013546 0.2995743 0.3348236 0.184689 0.06893488 0.09651531 -0.8246872 0.02523750 0.06506667 0.008933333 -0.05613333 0.045010202 0.009641784 FALSE  
ENST00000549617 ENSG00000120798 HEK293_OSMI2_2hA HEK293_TMG_2hB NR2C1 protein_coding retained_intron 15.16563 5.39291 21.80552 1.41038 1.022685 2.013546 1.5804803 1.1719593 1.641790 1.17195931 0.27217289 0.4828500 0.12950000 0.14306667 0.074666667 -0.06840000 0.545918646 0.009641784    
ENST00000552861 ENSG00000120798 HEK293_OSMI2_2hA HEK293_TMG_2hB NR2C1 protein_coding retained_intron 15.16563 5.39291 21.80552 1.41038 1.022685 2.013546 2.0049513 0.6051424 2.810700 0.15507006 0.13854809 2.1970607 0.12805417 0.11270000 0.128966667 0.01626667 0.712595264 0.009641784 TRUE  
MSTRG.7803.4 ENSG00000120798 HEK293_OSMI2_2hA HEK293_TMG_2hB NR2C1 protein_coding   15.16563 5.39291 21.80552 1.41038 1.022685 2.013546 3.0991979 0.6615180 5.467025 0.33228614 0.71214682 3.0278946 0.17830417 0.16733333 0.249666667 0.08233333 0.749213641 0.009641784 FALSE  
MSTRG.7803.5 ENSG00000120798 HEK293_OSMI2_2hA HEK293_TMG_2hB NR2C1 protein_coding   15.16563 5.39291 21.80552 1.41038 1.022685 2.013546 2.3409800 0.9314894 2.605578 0.16631967 0.30085120 1.4741131 0.15154583 0.17963333 0.118900000 -0.06073333 0.164794910 0.009641784 TRUE  
MSTRG.7803.8 ENSG00000120798 HEK293_OSMI2_2hA HEK293_TMG_2hB NR2C1 protein_coding   15.16563 5.39291 21.80552 1.41038 1.022685 2.013546 1.1142402 0.1213229 2.545524 0.07430879 1.01842205 4.2824283 0.05824167 0.01876667 0.121600000 0.10283333 0.157922121 0.009641784 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120798 E001 56.0640863 0.0013349759 1.085516e-01 2.034062e-01 12 95020229 95021892 1664 - 1.660 1.762 0.346
ENSG00000120798 E002 5.9946146 0.0027525772 1.770368e-01 2.973930e-01 12 95021893 95021920 28 - 0.828 0.626 -0.828
ENSG00000120798 E003 16.0631565 0.0032411886 9.165858e-01 9.512782e-01 12 95021921 95021940 20 - 1.159 1.182 0.081
ENSG00000120798 E004 30.8388217 0.0344016056 7.732266e-02 1.551934e-01 12 95021941 95022052 112 - 1.367 1.594 0.779
ENSG00000120798 E005 121.2495291 0.0098951277 2.837144e-03 9.784970e-03 12 95022053 95022333 281 - 1.960 2.156 0.655
ENSG00000120798 E006 68.9683980 0.0018363560 1.561670e-01 2.700332e-01 12 95022334 95022403 70 - 1.751 1.838 0.294
ENSG00000120798 E007 78.7394840 0.0003703791 5.850065e-01 7.087939e-01 12 95025150 95025255 106 - 1.820 1.858 0.128
ENSG00000120798 E008 3.7931139 0.0945365057 3.853917e-01 5.295778e-01 12 95025256 95025349 94 - 0.648 0.474 -0.804
ENSG00000120798 E009 2.4357437 0.0062214190 6.815808e-01 7.852282e-01 12 95026833 95026868 36 - 0.472 0.554 0.394
ENSG00000120798 E010 2.5613246 0.0098975806 8.998979e-02 1.751237e-01 12 95028106 95028386 281 - 0.559 0.217 -2.020
ENSG00000120798 E011 55.5980685 0.0004795188 9.449204e-02 1.821156e-01 12 95028387 95028457 71 - 1.656 1.758 0.346
ENSG00000120798 E012 52.7098679 0.0004762125 8.735303e-02 1.711228e-01 12 95028458 95028509 52 - 1.631 1.738 0.361
ENSG00000120798 E013 30.8560189 0.0006440095 1.721034e-01 2.909335e-01 12 95028510 95028524 15 - 1.405 1.514 0.375
ENSG00000120798 E014 0.1817044 0.0465020740 1.125033e-01   12 95030409 95030417 9 - 0.000 0.217 10.510
ENSG00000120798 E015 9.1413157 0.0436696235 5.576397e-07 4.889303e-06 12 95030418 95030629 212 - 0.631 1.370 2.775
ENSG00000120798 E016 12.2298617 0.0014288426 1.051640e-05 6.957086e-05 12 95030630 95030873 244 - 0.906 1.349 1.598
ENSG00000120798 E017 74.5643451 0.0007287003 3.828663e-02 8.788561e-02 12 95031349 95031488 140 - 1.782 1.891 0.370
ENSG00000120798 E018 77.0368340 0.0023392318 2.338386e-01 3.669408e-01 12 95040476 95040597 122 - 1.804 1.877 0.243
ENSG00000120798 E019 0.0000000       12 95040598 95040598 1 -      
ENSG00000120798 E020 70.6921782 0.0004224617 1.427722e-01 2.518091e-01 12 95049068 95049127 60 - 1.764 1.846 0.279
ENSG00000120798 E021 78.7573222 0.0003866777 6.171300e-01 7.350088e-01 12 95049128 95049233 106 - 1.833 1.821 -0.038
ENSG00000120798 E022 2.3366426 0.1051916747 5.551239e-01 6.840145e-01 12 95049234 95049492 259 - 0.496 0.362 -0.711
ENSG00000120798 E023 102.0205252 0.0003390068 9.340337e-03 2.713214e-02 12 95051762 95051943 182 - 1.961 1.862 -0.334
ENSG00000120798 E024 62.4625731 0.0009517022 2.630901e-02 6.456922e-02 12 95057553 95057643 91 - 1.754 1.640 -0.384
ENSG00000120798 E025 80.2386308 0.0005243048 2.309588e-05 1.411343e-04 12 95057731 95057878 148 - 1.876 1.671 -0.693
ENSG00000120798 E026 32.4017164 0.0022094958 7.622168e-01 8.458573e-01 12 95057879 95058309 431 - 1.450 1.440 -0.035
ENSG00000120798 E027 40.3902977 0.0006424956 3.554960e-02 8.270821e-02 12 95058310 95058347 38 - 1.573 1.439 -0.457
ENSG00000120798 E028 30.6401600 0.0112530971 3.421557e-01 4.861503e-01 12 95058348 95058352 5 - 1.450 1.372 -0.269
ENSG00000120798 E029 52.6069003 0.0044619437 3.653430e-01 5.096621e-01 12 95058353 95058408 56 - 1.669 1.621 -0.165
ENSG00000120798 E030 33.2600405 0.0027784623 6.931592e-01 7.942284e-01 12 95058409 95058419 11 - 1.467 1.450 -0.061
ENSG00000120798 E031 56.5464758 0.0004080624 1.560104e-02 4.184938e-02 12 95058420 95058489 70 - 1.714 1.585 -0.438
ENSG00000120798 E032 41.1718630 0.0008284737 3.509748e-03 1.175419e-02 12 95059906 95059919 14 - 1.591 1.397 -0.668
ENSG00000120798 E033 63.1466415 0.0004194511 1.402161e-01 2.483198e-01 12 95059920 95059984 65 - 1.750 1.683 -0.227
ENSG00000120798 E034 102.5833674 0.0003343225 2.912265e-01 4.320708e-01 12 95062508 95062738 231 - 1.951 1.920 -0.105
ENSG00000120798 E035 1.1887270 0.0121078980 7.750136e-01 8.550247e-01 12 95062850 95062887 38 - 0.297 0.360 0.393
ENSG00000120798 E036 0.0000000       12 95066928 95067330 403 -      
ENSG00000120798 E037 30.6672304 0.0006396235 3.316631e-02 7.813831e-02 12 95067331 95067336 6 - 1.465 1.309 -0.540
ENSG00000120798 E038 42.5188558 0.0005551086 7.482060e-02 1.512402e-01 12 95067337 95067391 55 - 1.593 1.488 -0.361
ENSG00000120798 E039 0.0000000       12 95072640 95073017 378 -      
ENSG00000120798 E040 57.9004830 0.0006215099 8.889478e-03 2.600421e-02 12 95073380 95073628 249 - 1.726 1.586 -0.479