ENSG00000120756

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000457734 ENSG00000120756 HEK293_OSMI2_2hA HEK293_TMG_2hB PLS1 protein_coding protein_coding 7.174894 1.730083 11.25218 0.05962742 0.1295425 2.694258 4.9100276 1.5298794 7.4456009 0.11039520 0.4768959 2.2755073 0.73877917 0.88233333 0.66100000 -0.22133333 9.942719e-03 1.470965e-07 FALSE TRUE
ENST00000476044 ENSG00000120756 HEK293_OSMI2_2hA HEK293_TMG_2hB PLS1 protein_coding protein_coding 7.174894 1.730083 11.25218 0.05962742 0.1295425 2.694258 1.4911713 0.0000000 2.6563949 0.00000000 0.4322226 8.0587466 0.11309583 0.00000000 0.23653333 0.23653333 1.470965e-07 1.470965e-07 FALSE TRUE
ENST00000483507 ENSG00000120756 HEK293_OSMI2_2hA HEK293_TMG_2hB PLS1 protein_coding retained_intron 7.174894 1.730083 11.25218 0.05962742 0.1295425 2.694258 0.2579985 0.1597318 0.3075583 0.07922726 0.1097822 0.9037643 0.05354583 0.09556667 0.02743333 -0.06813333 2.869733e-01 1.470965e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120756 E001 2.0379919 0.0069503795 0.978621192 0.99076472 3 142596393 142596415 23 + 0.386 0.420 0.188
ENSG00000120756 E002 2.6377108 0.0154983054 0.656397450 0.76598786 3 142596416 142596417 2 + 0.470 0.420 -0.259
ENSG00000120756 E003 7.1669706 0.0227537391 0.177113870 0.29747569 3 142596418 142596431 14 + 0.819 0.630 -0.778
ENSG00000120756 E004 9.8167726 0.0056274601 0.482783624 0.62089316 3 142596432 142596437 6 + 0.918 0.876 -0.160
ENSG00000120756 E005 9.8167726 0.0056274601 0.482783624 0.62089316 3 142596438 142596439 2 + 0.918 0.876 -0.160
ENSG00000120756 E006 12.9418361 0.0014372587 0.176543558 0.29675126 3 142596440 142596454 15 + 1.037 0.921 -0.431
ENSG00000120756 E007 20.9608398 0.0009026966 0.103745857 0.19621769 3 142596455 142596509 55 + 1.230 1.121 -0.389
ENSG00000120756 E008 1.3995631 0.0096885266 0.195433257 0.32050350 3 142597237 142597348 112 + 0.250 0.537 1.646
ENSG00000120756 E009 0.0000000       3 142619453 142619638 186 +      
ENSG00000120756 E010 0.0000000       3 142623386 142623406 21 +      
ENSG00000120756 E011 0.0000000       3 142623407 142623562 156 +      
ENSG00000120756 E012 0.2955422 0.0295045950 0.223338536   3 142627816 142627908 93 + 0.053 0.258 2.644
ENSG00000120756 E013 1.4907137 0.0120373847 0.608628687 0.72830245 3 142645296 142645580 285 + 0.337 0.259 -0.525
ENSG00000120756 E014 0.1451727 0.0429123794 1.000000000   3 142656897 142657180 284 + 0.053 0.001 -6.730
ENSG00000120756 E015 0.0000000       3 142664122 142664201 80 +      
ENSG00000120756 E016 15.7554748 0.0011823247 0.229187317 0.36146830 3 142664202 142664209 8 + 1.113 1.032 -0.292
ENSG00000120756 E017 30.3704239 0.0007214289 0.033519071 0.07881063 3 142664210 142664307 98 + 1.385 1.258 -0.445
ENSG00000120756 E018 47.8169655 0.0013916332 0.036518804 0.08456538 3 142669390 142669553 164 + 1.569 1.482 -0.296
ENSG00000120756 E019 42.5815738 0.0005495244 0.015611229 0.04186905 3 142670993 142671122 130 + 1.525 1.405 -0.412
ENSG00000120756 E020 42.5323731 0.0277568668 0.721354066 0.81576855 3 142676157 142676289 133 + 1.498 1.537 0.135
ENSG00000120756 E021 36.8459741 0.0017276017 0.806967264 0.87738117 3 142678032 142678113 82 + 1.438 1.482 0.153
ENSG00000120756 E022 56.0155276 0.0004672212 0.664950849 0.77268443 3 142684006 142684171 166 + 1.608 1.698 0.306
ENSG00000120756 E023 48.1551309 0.0040817238 0.838865668 0.89928895 3 142684253 142684395 143 + 1.553 1.603 0.172
ENSG00000120756 E024 38.3487292 0.0071820780 0.222168806 0.35299674 3 142686284 142686376 93 + 1.474 1.432 -0.145
ENSG00000120756 E025 21.2657886 0.0236148024 0.065460988 0.13581037 3 142689618 142689629 12 + 1.248 1.063 -0.661
ENSG00000120756 E026 51.4733401 0.0005047424 0.801549938 0.87354240 3 142689630 142689813 184 + 1.581 1.629 0.164
ENSG00000120756 E027 39.3232809 0.0007363440 0.891634679 0.93478498 3 142694469 142694547 79 + 1.462 1.516 0.185
ENSG00000120756 E028 50.9038319 0.0006297179 0.013893776 0.03798557 3 142697953 142698067 115 + 1.599 1.493 -0.363
ENSG00000120756 E029 2.0888048 0.0115487340 0.050292027 0.10968243 3 142698068 142698438 371 + 0.310 0.705 1.970
ENSG00000120756 E030 49.9024578 0.0005207098 0.033896122 0.07954432 3 142703868 142704001 134 + 1.586 1.505 -0.280
ENSG00000120756 E031 40.6626329 0.0007901191 0.932828066 0.96167627 3 142704463 142704586 124 + 1.477 1.547 0.238
ENSG00000120756 E032 40.1751544 0.0110619692 0.816990057 0.88422893 3 142711501 142711625 125 + 1.473 1.555 0.282
ENSG00000120756 E033 163.2091831 0.0439788619 0.004825494 0.01544528 3 142711872 142713664 1793 + 2.014 2.334 1.073