ENSG00000120709

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239906 ENSG00000120709 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM53C protein_coding protein_coding 52.75114 79.14047 41.41783 3.498464 0.7133935 -0.9339976 41.273741 53.05253 37.48778 5.870916 0.7661539 -0.5008883 0.8091000 0.6668 0.905 0.2382 5.651436e-07 7.739248e-29 FALSE TRUE
ENST00000513056 ENSG00000120709 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM53C protein_coding protein_coding 52.75114 79.14047 41.41783 3.498464 0.7133935 -0.9339976 7.564787 22.01592 0.00000 2.920226 0.0000000 -11.1049866 0.1097792 0.2815 0.000 -0.2815 7.739248e-29 7.739248e-29 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120709 E001 0.1451727 0.043431121 2.478159e-01   5 138331935 138331969 35 + 0.144 0.000 -25.346
ENSG00000120709 E002 6.9672538 0.045440913 7.981185e-01 8.711581e-01 5 138332105 138332185 81 + 0.839 0.925 0.332
ENSG00000120709 E003 9.3350517 0.057017389 7.530726e-01 8.391210e-01 5 138333433 138333528 96 + 0.948 1.040 0.341
ENSG00000120709 E004 0.1515154 0.043493138 2.474511e-01   5 138333677 138333739 63 + 0.144 0.000 -25.352
ENSG00000120709 E005 0.1482932 0.041982433 1.000000e+00   5 138335088 138335138 51 + 0.000 0.103 23.979
ENSG00000120709 E006 9.5356694 0.083203471 9.748361e-01 9.883323e-01 5 138335385 138335485 101 + 0.908 1.066 0.588
ENSG00000120709 E007 0.8899480 0.018609351 7.616809e-01 8.455004e-01 5 138336789 138336807 19 + 0.252 0.257 0.040
ENSG00000120709 E008 7.5652082 0.004715772 9.234003e-01 9.557171e-01 5 138336874 138337146 273 + 0.839 0.945 0.405
ENSG00000120709 E009 0.8115992 0.016400583 2.302764e-01 3.627903e-01 5 138337511 138337553 43 + 0.338 0.187 -1.132
ENSG00000120709 E010 3.9375139 0.004858392 2.288796e-02 5.750736e-02 5 138337554 138337852 299 + 0.813 0.598 -0.896
ENSG00000120709 E011 20.9050093 0.003159122 2.875650e-01 4.280632e-01 5 138338015 138338265 251 + 1.290 1.332 0.149
ENSG00000120709 E012 13.1654070 0.011470745 8.284615e-01 8.922100e-01 5 138338266 138338266 1 + 1.066 1.169 0.371
ENSG00000120709 E013 205.4743075 0.014421722 6.052530e-03 1.874840e-02 5 138338267 138338307 41 + 2.312 2.286 -0.088
ENSG00000120709 E014 8.7650866 0.001919696 2.047932e-02 5.250066e-02 5 138341181 138341183 3 + 1.050 0.918 -0.492
ENSG00000120709 E015 300.9707817 0.008728570 3.230354e-04 1.473020e-03 5 138341184 138341264 81 + 2.482 2.449 -0.109
ENSG00000120709 E016 436.5506521 0.003735626 9.963892e-09 1.229486e-07 5 138341265 138341413 149 + 2.654 2.604 -0.167
ENSG00000120709 E017 14.2169320 0.018312407 2.472713e-09 3.408382e-08 5 138341414 138341808 395 + 1.425 0.902 -1.875
ENSG00000120709 E018 258.2040677 0.004406230 2.061444e-06 1.598847e-05 5 138341809 138341866 58 + 2.423 2.378 -0.148
ENSG00000120709 E019 29.4050689 0.004355981 1.244117e-14 4.037934e-13 5 138341867 138343023 1157 + 1.679 1.268 -1.418
ENSG00000120709 E020 5.5198146 0.004534236 1.407702e-04 7.068432e-04 5 138343709 138343749 41 + 1.002 0.626 -1.486
ENSG00000120709 E021 772.5027666 0.002154221 1.683019e-08 1.989287e-07 5 138344825 138345395 571 + 2.869 2.871 0.006
ENSG00000120709 E022 375.5986980 0.003802375 2.030642e-05 1.257392e-04 5 138345396 138345609 214 + 2.563 2.555 -0.027
ENSG00000120709 E023 5199.5695780 0.006214091 2.110447e-10 3.519833e-09 5 138346702 138349729 3028 + 3.540 3.768 0.756