ENSG00000120705

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360541 ENSG00000120705 HEK293_OSMI2_2hA HEK293_TMG_2hB ETF1 protein_coding protein_coding 76.41421 28.59527 134.9308 2.704173 5.864004 2.237974 54.20259 26.4549087 91.02200 3.3225664 3.066598 1.782293 0.7890833 0.9202 0.6751667 -0.2450333 0.003934920 0.00393492 FALSE TRUE
ENST00000503014 ENSG00000120705 HEK293_OSMI2_2hA HEK293_TMG_2hB ETF1 protein_coding protein_coding 76.41421 28.59527 134.9308 2.704173 5.864004 2.237974 11.29271 0.1722042 22.94693 0.1722042 2.710434 6.977230 0.0900750 0.0065 0.1689333 0.1624333 0.005699183 0.00393492 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120705 E001 1008.8162974 0.0177164958 2.127379e-05 1.310780e-04 5 138506095 138506872 778 - 2.813 3.170 1.186
ENSG00000120705 E002 1967.4866408 0.0017221727 5.600541e-16 2.188092e-14 5 138506873 138507989 1117 - 3.147 3.380 0.774
ENSG00000120705 E003 1052.4054622 0.0018260948 5.083860e-04 2.191239e-03 5 138507990 138508387 398 - 2.897 3.055 0.524
ENSG00000120705 E004 753.4023658 0.0045551893 6.163669e-01 7.344323e-01 5 138508669 138508816 148 - 2.778 2.832 0.182
ENSG00000120705 E005 446.6421239 0.0031530622 7.395543e-01 8.292131e-01 5 138510565 138510629 65 - 2.549 2.613 0.214
ENSG00000120705 E006 402.0638946 0.0032167225 8.191005e-01 8.857641e-01 5 138511045 138511103 59 - 2.503 2.571 0.226
ENSG00000120705 E007 583.0931238 0.0002694887 9.752797e-05 5.104396e-04 5 138511104 138511200 97 - 2.678 2.686 0.026
ENSG00000120705 E008 10.0794553 0.0018913856 2.177559e-01 3.476970e-01 5 138511201 138511474 274 - 0.981 0.899 -0.310
ENSG00000120705 E009 441.9256078 0.0002157373 4.011543e-04 1.778842e-03 5 138511475 138511524 50 - 2.558 2.566 0.026
ENSG00000120705 E010 438.6162696 0.0009194686 7.917287e-03 2.357083e-02 5 138511525 138511604 80 - 2.553 2.567 0.046
ENSG00000120705 E011 8.4115270 0.0045711568 7.849576e-01 8.621195e-01 5 138512699 138512763 65 - 0.862 0.969 0.405
ENSG00000120705 E012 232.6771190 0.0003424579 8.832397e-02 1.725662e-01 5 138512764 138512771 8 - 2.276 2.310 0.113
ENSG00000120705 E013 761.9221877 0.0003430048 4.979367e-10 7.794795e-09 5 138512772 138512954 183 - 2.802 2.774 -0.092
ENSG00000120705 E014 511.6526336 0.0001309081 3.413222e-12 7.680541e-11 5 138513568 138513650 83 - 2.635 2.580 -0.184
ENSG00000120705 E015 424.9200330 0.0005172739 6.623422e-11 1.203518e-09 5 138513651 138513706 56 - 2.558 2.483 -0.250
ENSG00000120705 E016 691.0072110 0.0001517589 4.076882e-34 9.384605e-32 5 138517561 138517700 140 - 2.779 2.641 -0.457
ENSG00000120705 E017 706.2431032 0.0010110324 3.954431e-28 5.641228e-26 5 138518692 138518867 176 - 2.794 2.617 -0.588
ENSG00000120705 E018 13.4312600 0.0034631517 2.493085e-01 3.851014e-01 5 138529555 138529678 124 - 1.086 1.029 -0.206
ENSG00000120705 E019 0.9587596 0.0133274374 1.817522e-02 4.750937e-02 5 138541519 138541711 193 - 0.116 0.576 3.171
ENSG00000120705 E020 5.6099967 0.0032980098 8.011533e-01 8.732852e-01 5 138542634 138542704 71 - 0.736 0.767 0.125
ENSG00000120705 E021 16.1911667 0.0028746053 1.946610e-01 3.195718e-01 5 138542705 138542832 128 - 1.165 1.106 -0.213
ENSG00000120705 E022 371.0340603 0.0025572093 4.170228e-15 1.451474e-13 5 138542833 138542936 104 - 2.518 2.321 -0.658
ENSG00000120705 E023 194.5138841 0.0047260012 1.003283e-05 6.665107e-05 5 138543097 138543267 171 - 2.229 2.099 -0.436