ENSG00000120697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239891 ENSG00000120697 HEK293_OSMI2_2hA HEK293_TMG_2hB ALG5 protein_coding protein_coding 50.83072 25.40074 78.6772 4.415856 2.190644 1.630691 16.041678 9.539620 31.807567 0.9954902 3.69064382 1.73630832 0.3082500 0.39403333 0.4075667 0.01353333 0.972985311 0.002353396 FALSE  
ENST00000680671 ENSG00000120697 HEK293_OSMI2_2hA HEK293_TMG_2hB ALG5 protein_coding protein_coding 50.83072 25.40074 78.6772 4.415856 2.190644 1.630691 11.187850 1.961320 15.235577 1.9613202 3.55114543 2.95115676 0.1818917 0.05746667 0.1953000 0.13783333 0.139192502 0.002353396 FALSE  
ENST00000681893 ENSG00000120697 HEK293_OSMI2_2hA HEK293_TMG_2hB ALG5 protein_coding protein_coding 50.83072 25.40074 78.6772 4.415856 2.190644 1.630691 13.713332 8.197897 17.276959 2.4481433 6.42093908 1.07459956 0.2797250 0.31006667 0.2157333 -0.09433333 0.626474989 0.002353396 FALSE  
MSTRG.8613.25 ENSG00000120697 HEK293_OSMI2_2hA HEK293_TMG_2hB ALG5 protein_coding   50.83072 25.40074 78.6772 4.415856 2.190644 1.630691 1.643032 1.669683 1.587824 0.2063185 0.08409549 -0.07208042 0.0432750 0.07113333 0.0202000 -0.05093333 0.002353396 0.002353396 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120697 E001 5.0752230 0.0038030065 4.228097e-02 9.523813e-02 13 36949738 36949838 101 - 0.662 0.930 1.067
ENSG00000120697 E002 5.0450340 0.0115644204 1.098997e-01 2.053959e-01 13 36949839 36949840 2 - 0.681 0.903 0.881
ENSG00000120697 E003 5.6372644 0.0096237954 1.460497e-01 2.563172e-01 13 36949841 36949845 5 - 0.735 0.930 0.759
ENSG00000120697 E004 7.3043839 0.0090170145 2.339140e-01 3.670317e-01 13 36949846 36949847 2 - 0.853 1.000 0.555
ENSG00000120697 E005 8.3717699 0.0032159668 6.958965e-02 1.426732e-01 13 36949848 36949848 1 - 0.878 1.080 0.753
ENSG00000120697 E006 9.9603226 0.0030993683 7.384651e-03 2.221799e-02 13 36949849 36949852 4 - 0.913 1.191 1.017
ENSG00000120697 E007 16.8773911 0.0020629012 2.134133e-01 3.425502e-01 13 36949853 36949861 9 - 1.198 1.302 0.366
ENSG00000120697 E008 44.4119661 0.0005746331 7.902202e-05 4.232649e-04 13 36949862 36949900 39 - 1.564 1.772 0.704
ENSG00000120697 E009 92.0125604 0.0017258960 2.543698e-06 1.934859e-05 13 36949901 36949930 30 - 1.879 2.074 0.653
ENSG00000120697 E010 88.7012528 0.0009672933 9.422611e-07 7.861042e-06 13 36949931 36949932 2 - 1.864 2.058 0.652
ENSG00000120697 E011 87.2057356 0.0031949167 3.417813e-05 2.004192e-04 13 36949933 36949933 1 - 1.857 2.049 0.646
ENSG00000120697 E012 89.3586094 0.0031448192 6.062006e-05 3.345361e-04 13 36949934 36949941 8 - 1.871 2.055 0.618
ENSG00000120697 E013 182.7309696 0.0049731341 1.311470e-03 5.015526e-03 13 36949942 36949993 52 - 2.196 2.332 0.455
ENSG00000120697 E014 214.4095541 0.0002386839 1.306186e-04 6.614975e-04 13 36949994 36950024 31 - 2.285 2.378 0.311
ENSG00000120697 E015 214.0700280 0.0002719428 1.050948e-04 5.455963e-04 13 36950025 36950057 33 - 2.283 2.379 0.319
ENSG00000120697 E016 6.7948720 0.0472690980 6.754723e-01 7.807485e-01 13 36950058 36952513 2456 - 0.853 0.925 0.272
ENSG00000120697 E017 294.5802249 0.0002004220 7.606349e-02 1.532144e-01 13 36952514 36952599 86 - 2.442 2.477 0.117
ENSG00000120697 E018 3.3308108 0.0321360708 1.992426e-03 7.202868e-03 13 36952600 36953026 427 - 0.394 0.900 2.232
ENSG00000120697 E019 0.9672673 0.0159490479 8.368210e-01 8.979559e-01 13 36963994 36964714 721 - 0.266 0.302 0.249
ENSG00000120697 E020 4.7663702 0.0906346141 7.218934e-01 8.161252e-01 13 36964715 36965574 860 - 0.768 0.659 -0.446
ENSG00000120697 E021 358.5640752 0.0001607590 1.048375e-01 1.978557e-01 13 36965575 36965726 152 - 2.529 2.556 0.092
ENSG00000120697 E022 5.0001876 0.0031424626 5.058896e-01 6.415975e-01 13 36967672 36967807 136 - 0.798 0.700 -0.396
ENSG00000120697 E023 1.2544922 0.0108647759 2.669973e-01 4.052675e-01 13 36967808 36968056 249 - 0.394 0.177 -1.557
ENSG00000120697 E024 173.1636301 0.0012237558 2.464817e-01 3.818337e-01 13 36971977 36972036 60 - 2.211 2.240 0.098
ENSG00000120697 E025 2.9903810 0.0434773728 3.983168e-01 5.420505e-01 13 36975761 36975853 93 - 0.521 0.657 0.608
ENSG00000120697 E026 0.0000000       13 36984243 36984399 157 -      
ENSG00000120697 E027 0.0000000       13 36984400 36985626 1227 -      
ENSG00000120697 E028 348.4057911 0.0008738010 3.889671e-02 8.898950e-02 13 36985627 36985740 114 - 2.542 2.484 -0.192
ENSG00000120697 E029 1.5283913 0.1199647904 2.204786e-01 3.509893e-01 13 36989412 36989483 72 - 0.463 0.177 -1.923
ENSG00000120697 E030 364.6136276 0.0001410044 6.480801e-08 6.827762e-07 13 36989484 36989555 72 - 2.579 2.465 -0.379
ENSG00000120697 E031 255.0220238 0.0001739753 9.414434e-04 3.759245e-03 13 36989556 36989576 21 - 2.416 2.332 -0.280
ENSG00000120697 E032 1.7673295 0.0082495683 8.155686e-03 2.417685e-02 13 36989577 36993603 4027 - 0.548 0.000 -11.302
ENSG00000120697 E033 351.8549552 0.0002117855 8.947737e-07 7.506186e-06 13 36993604 36993672 69 - 2.561 2.453 -0.360
ENSG00000120697 E034 2.2488425 0.0063327359 1.452220e-01 2.551436e-01 13 36993673 36994988 1316 - 0.573 0.302 -1.452
ENSG00000120697 E035 310.8678924 0.0002172730 2.215029e-08 2.561378e-07 13 36994989 36995035 47 - 2.513 2.382 -0.437
ENSG00000120697 E036 2.0003262 0.0088549948 9.215459e-01 9.544705e-01 13 36995036 36995424 389 - 0.462 0.478 0.078
ENSG00000120697 E037 200.4367188 0.0034773245 5.589598e-04 2.380918e-03 13 36995425 36995426 2 - 2.328 2.173 -0.518
ENSG00000120697 E038 380.8483846 0.0053248066 1.277675e-02 3.538974e-02 13 36995427 36995596 170 - 2.596 2.474 -0.407
ENSG00000120697 E039 0.6319842 0.0295716910 9.002474e-01 9.403488e-01 13 36995597 36995616 20 - 0.213 0.177 -0.336
ENSG00000120697 E040 133.3555641 0.0151808934 7.569293e-02 1.526111e-01 13 36999235 36999352 118 - 2.151 2.000 -0.505
ENSG00000120697 E041 1.9445745 0.0077523400 8.756465e-03 2.567577e-02 13 36999592 36999644 53 - 0.266 0.700 2.248
ENSG00000120697 E042 23.0476684 0.0098565871 1.124801e-14 3.672071e-13 13 36999932 37000261 330 - 1.021 1.673 2.278
ENSG00000120697 E043 9.6288068 0.0019114986 1.568117e-06 1.247952e-05 13 37000697 37000763 67 - 0.768 1.269 1.855
ENSG00000120697 E044 16.3524246 0.0664516716 1.538641e-02 4.136677e-02 13 37000905 37001233 329 - 1.079 1.396 1.120