ENSG00000120694

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380405 ENSG00000120694 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPH1 protein_coding protein_coding 72.7154 33.83081 124.5819 1.073555 2.605293 1.880374 19.849479 5.918817 38.92371 1.0994091 0.5530884 2.715203 0.24512500 0.1756000 0.3125333 0.13693333 3.918128e-02 3.040755e-51 FALSE TRUE
ENST00000435381 ENSG00000120694 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPH1 protein_coding protein_coding 72.7154 33.83081 124.5819 1.073555 2.605293 1.880374 2.312324 6.820542 0.00000 1.5075901 0.0000000 -9.415856 0.06582083 0.2020333 0.0000000 -0.20203333 1.472938e-29 3.040755e-51 FALSE TRUE
ENST00000602786 ENSG00000120694 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPH1 protein_coding nonsense_mediated_decay 72.7154 33.83081 124.5819 1.073555 2.605293 1.880374 17.930178 9.636569 28.58190 0.7628222 1.1290753 1.567519 0.26215417 0.2844000 0.2294667 -0.05493333 1.733019e-01 3.040755e-51 FALSE TRUE
ENST00000630972 ENSG00000120694 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPH1 protein_coding protein_coding 72.7154 33.83081 124.5819 1.073555 2.605293 1.880374 18.325524 9.558213 23.04429 0.5937163 4.0851423 1.268714 0.26962917 0.2820000 0.1847000 -0.09730000 1.250208e-01 3.040755e-51 FALSE TRUE
MSTRG.8556.8 ENSG00000120694 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPH1 protein_coding   72.7154 33.83081 124.5819 1.073555 2.605293 1.880374 6.399341 0.000000 16.98593 0.0000000 0.7202257 10.730973 0.06775417 0.0000000 0.1365000 0.13650000 3.040755e-51 3.040755e-51 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120694 E001 0.6277178 0.0300989432 8.625284e-01 9.153484e-01 13 31134973 31134973 1 - 0.176 0.213 0.342
ENSG00000120694 E002 110.5249399 0.0012907510 4.024599e-03 1.321034e-02 13 31134974 31136624 1651 - 1.945 2.080 0.452
ENSG00000120694 E003 19.5446711 0.0010680409 6.034395e-03 1.870110e-02 13 31136625 31136627 3 - 1.177 1.421 0.856
ENSG00000120694 E004 174.9059876 0.0138389689 2.316424e-05 1.415155e-04 13 31136628 31136750 123 - 2.088 2.382 0.980
ENSG00000120694 E005 583.5644211 0.0064000842 8.950444e-12 1.879653e-10 13 31136751 31136972 222 - 2.606 2.906 0.998
ENSG00000120694 E006 583.3871945 0.0037357690 7.019671e-14 2.037781e-12 13 31136973 31137117 145 - 2.619 2.884 0.882
ENSG00000120694 E007 632.3273852 0.0039947720 7.856116e-18 3.910451e-16 13 31137118 31137367 250 - 2.639 2.943 1.010
ENSG00000120694 E008 727.6632408 0.0021616193 1.474657e-10 2.529604e-09 13 31137368 31137524 157 - 2.742 2.927 0.613
ENSG00000120694 E009 738.2107143 0.0012442829 1.766722e-08 2.080822e-07 13 31138407 31138538 132 - 2.761 2.903 0.472
ENSG00000120694 E010 417.1564101 0.0005485056 5.082883e-04 2.190933e-03 13 31138539 31138568 30 - 2.527 2.621 0.316
ENSG00000120694 E011 677.6709946 0.0003771332 1.797966e-08 2.113810e-07 13 31138781 31138900 120 - 2.731 2.847 0.384
ENSG00000120694 E012 629.0935001 0.0003080207 1.055494e-05 6.978439e-05 13 31139000 31139107 108 - 2.705 2.800 0.316
ENSG00000120694 E013 2.5132508 0.0064061796 3.597592e-01 5.040849e-01 13 31139108 31139182 75 - 0.523 0.356 -0.880
ENSG00000120694 E014 707.9698649 0.0001322251 1.229015e-03 4.739220e-03 13 31140184 31140309 126 - 2.764 2.832 0.225
ENSG00000120694 E015 7.1761928 0.0501309383 7.886673e-01 8.647107e-01 13 31140310 31141121 812 - 0.866 0.825 -0.160
ENSG00000120694 E016 723.6771356 0.0001463393 6.077945e-02 1.279407e-01 13 31141122 31141259 138 - 2.795 2.780 -0.048
ENSG00000120694 E017 602.3327883 0.0002307019 1.270945e-02 3.522961e-02 13 31143792 31143923 132 - 2.719 2.689 -0.099
ENSG00000120694 E018 773.6437701 0.0010670121 3.620859e-07 3.293772e-06 13 31145563 31145768 206 - 2.842 2.747 -0.314
ENSG00000120694 E019 557.4684359 0.0018231365 7.922120e-05 4.241886e-04 13 31147959 31148092 134 - 2.699 2.607 -0.307
ENSG00000120694 E020 471.8172681 0.0030219500 4.046255e-03 1.327085e-02 13 31148374 31148480 107 - 2.624 2.546 -0.259
ENSG00000120694 E021 782.3696368 0.0017551393 8.163841e-09 1.023164e-07 13 31149954 31150182 229 - 2.853 2.724 -0.429
ENSG00000120694 E022 826.1721560 0.0053620504 2.988600e-09 4.055449e-08 13 31150947 31151191 245 - 2.891 2.683 -0.694
ENSG00000120694 E023 7.0101592 0.0068720641 1.017746e-03 4.020110e-03 13 31151192 31151608 417 - 0.930 0.356 -2.566
ENSG00000120694 E024 573.5503875 0.0022544869 1.418107e-13 3.943287e-12 13 31151609 31151742 134 - 2.732 2.527 -0.683
ENSG00000120694 E025 28.3918970 0.0006768809 2.115144e-11 4.174038e-10 13 31151743 31152501 759 - 1.494 0.784 -2.573
ENSG00000120694 E026 458.3007844 0.0065828194 1.622438e-04 8.016223e-04 13 31152852 31152951 100 - 2.624 2.477 -0.491
ENSG00000120694 E027 9.5292496 0.0017162875 1.779324e-06 1.399342e-05 13 31153979 31154632 654 - 1.061 0.213 -4.050
ENSG00000120694 E028 496.9498999 0.0001585176 2.318700e-13 6.263663e-12 13 31154633 31154755 123 - 2.657 2.522 -0.449
ENSG00000120694 E029 219.8613384 0.0001886930 5.515519e-08 5.888411e-07 13 31155514 31155514 1 - 2.307 2.156 -0.504
ENSG00000120694 E030 464.2286433 0.0001363250 1.250638e-23 1.189406e-21 13 31155515 31155654 140 - 2.640 2.438 -0.673
ENSG00000120694 E031 288.5460811 0.0008319076 4.219333e-18 2.153975e-16 13 31158806 31158863 58 - 2.442 2.188 -0.848
ENSG00000120694 E032 548.4693291 0.0078283079 1.538852e-06 1.226879e-05 13 31161476 31161981 506 - 2.713 2.507 -0.686
ENSG00000120694 E033 17.7969737 0.0144728589 2.160274e-02 5.485551e-02 13 31161982 31162388 407 - 1.259 0.996 -0.947