ENSG00000120690

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239882 ENSG00000120690 HEK293_OSMI2_2hA HEK293_TMG_2hB ELF1 protein_coding protein_coding 4.909568 2.108951 7.340931 0.07944786 0.03908278 1.794577 1.1788193 1.089365 1.238525 0.1592607 0.36651079 0.1835543 0.3366917 0.5228333 0.1686000 -0.3542333 2.485727e-02 2.154031e-08 FALSE TRUE
ENST00000635415 ENSG00000120690 HEK293_OSMI2_2hA HEK293_TMG_2hB ELF1 protein_coding protein_coding 4.909568 2.108951 7.340931 0.07944786 0.03908278 1.794577 0.8536849 0.000000 1.756895 0.0000000 0.31466309 7.4650722 0.1055167 0.0000000 0.2393333 0.2393333 2.154031e-08 2.154031e-08 FALSE TRUE
MSTRG.8633.3 ENSG00000120690 HEK293_OSMI2_2hA HEK293_TMG_2hB ELF1 protein_coding   4.909568 2.108951 7.340931 0.07944786 0.03908278 1.794577 2.5602585 1.019585 4.306504 0.2327934 0.06510575 2.0677998 0.5172958 0.4771667 0.5866667 0.1095000 5.701783e-01 2.154031e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120690 E001 0.9985004 0.0126851412 4.008847e-02 9.119624e-02 13 40931924 40932027 104 - 0.139 0.510 2.565
ENSG00000120690 E002 15.2576932 0.0368612357 3.159491e-04 1.444532e-03 13 40932028 40932357 330 - 0.987 1.453 1.653
ENSG00000120690 E003 120.5941389 0.0044491747 5.588372e-11 1.028663e-09 13 40932358 40933351 994 - 1.945 2.219 0.918
ENSG00000120690 E004 25.9236067 0.0104729739 5.998989e-02 1.265847e-01 13 40933352 40933438 87 - 1.335 1.508 0.599
ENSG00000120690 E005 88.5542091 0.0006234382 1.309237e-01 2.354329e-01 13 40933439 40934028 590 - 1.922 1.881 -0.139
ENSG00000120690 E006 63.5699509 0.0032770623 5.261928e-02 1.138159e-01 13 40940921 40941370 450 - 1.792 1.706 -0.288
ENSG00000120690 E007 42.4638701 0.0005413711 9.058827e-04 3.634485e-03 13 40942952 40943144 193 - 1.641 1.454 -0.639
ENSG00000120690 E008 31.0392391 0.0023643779 2.735180e-02 6.671021e-02 13 40943842 40943925 84 - 1.503 1.359 -0.497
ENSG00000120690 E009 25.5106388 0.0013733311 5.545809e-02 1.187729e-01 13 40949806 40949901 96 - 1.421 1.289 -0.456
ENSG00000120690 E010 19.9723175 0.0191615964 5.167559e-01 6.512890e-01 13 40949902 40949973 72 - 1.299 1.249 -0.176
ENSG00000120690 E011 27.0779998 0.0007840177 2.377224e-01 3.715059e-01 13 40951329 40951436 108 - 1.427 1.359 -0.236
ENSG00000120690 E012 0.1515154 0.0433184635 1.000000e+00   13 40951584 40951701 118 - 0.075 0.000 -7.633
ENSG00000120690 E013 46.3588634 0.0038803463 8.812774e-02 1.722752e-01 13 40958836 40959016 181 - 1.656 1.567 -0.303
ENSG00000120690 E014 47.2623681 0.0096060391 3.129681e-02 7.447760e-02 13 40981983 40982282 300 - 1.676 1.540 -0.462
ENSG00000120690 E015 0.4502799 0.0314773477 4.054860e-01 5.491716e-01 13 40982858 40982899 42 - 0.195 0.000 -9.218
ENSG00000120690 E016 1.6619082 0.0095805385 7.813630e-01 8.595497e-01 13 41019228 41019316 89 - 0.366 0.429 0.346
ENSG00000120690 E017 36.8903703 0.0508928778 2.921488e-01 4.330914e-01 13 41060838 41061440 603 - 1.559 1.466 -0.318