ENSG00000120686

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239878 ENSG00000120686 HEK293_OSMI2_2hA HEK293_TMG_2hB UFM1 protein_coding protein_coding 18.44359 12.90093 28.21167 2.495153 1.202272 1.128211 11.437946 5.0659793 18.493762 0.4713574 0.5640466 1.8660605 0.57334167 0.42516667 0.65640000 0.23123333 0.10081535 2.300629e-05 FALSE FALSE
MSTRG.8602.1 ENSG00000120686 HEK293_OSMI2_2hA HEK293_TMG_2hB UFM1 protein_coding   18.44359 12.90093 28.21167 2.495153 1.202272 1.128211 3.776093 7.0045448 4.532204 2.4666889 0.2012379 -0.6269569 0.27836667 0.49890000 0.16170000 -0.33720000 0.01868487 2.300629e-05   FALSE
MSTRG.8602.2 ENSG00000120686 HEK293_OSMI2_2hA HEK293_TMG_2hB UFM1 protein_coding   18.44359 12.90093 28.21167 2.495153 1.202272 1.128211 1.419489 0.4695933 2.021480 0.1573409 0.6964611 2.0826476 0.06236667 0.04593333 0.07166667 0.02573333 0.64351260 2.300629e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120686 E001 0.147249 0.0458076883 1.000000e+00   13 38349701 38349801 101 + 0.112 0.000 -11.683
ENSG00000120686 E002 4.395168 0.0042892894 3.409927e-01 4.849197e-01 13 38349802 38349831 30 + 0.756 0.726 -0.121
ENSG00000120686 E003 8.879042 0.0022746061 2.746237e-01 4.138019e-01 13 38349832 38349848 17 + 1.029 0.968 -0.226
ENSG00000120686 E004 13.250377 0.0013757193 2.203116e-01 3.507961e-01 13 38349849 38349850 2 + 1.196 1.122 -0.262
ENSG00000120686 E005 62.277853 0.0028490488 4.482666e-02 9.988389e-02 13 38349851 38349885 35 + 1.853 1.758 -0.320
ENSG00000120686 E006 129.177780 0.0005413771 4.739734e-13 1.225005e-11 13 38349886 38349921 36 + 2.110 2.139 0.096
ENSG00000120686 E007 2.587369 0.2107562543 2.049183e-01 3.322989e-01 13 38349922 38349995 74 + 0.486 0.598 0.523
ENSG00000120686 E008 2.800398 0.1772288355 8.431283e-01 9.022823e-01 13 38349996 38349998 3 + 0.627 0.508 -0.544
ENSG00000120686 E009 172.482335 0.0046696098 4.285910e-09 5.647995e-08 13 38349999 38350055 57 + 2.227 2.262 0.117
ENSG00000120686 E010 5.355177 0.0030902057 4.986475e-01 6.351083e-01 13 38350056 38350227 172 + 0.921 0.663 -1.028
ENSG00000120686 E011 170.969114 0.0031534866 1.323443e-13 3.699060e-12 13 38354239 38354296 58 + 2.208 2.274 0.221
ENSG00000120686 E012 3.844033 0.0042757302 7.919938e-06 5.384563e-05 13 38354297 38354885 589 + 0.936 0.000 -16.382
ENSG00000120686 E013 114.913606 0.0006694152 3.507017e-27 4.607447e-25 13 38358093 38358132 40 + 1.986 2.150 0.549
ENSG00000120686 E014 101.493440 0.0008847197 4.432528e-09 5.831857e-08 13 38359301 38359333 33 + 2.010 2.024 0.046
ENSG00000120686 E015 12.996479 0.0013327230 2.314473e-06 1.775758e-05 13 38359334 38359781 448 + 1.368 0.663 -2.631
ENSG00000120686 E016 14.144931 0.0013629656 3.366869e-01 4.805569e-01 13 38360041 38360221 181 + 1.234 1.134 -0.358
ENSG00000120686 E017 917.946234 0.0257523795 1.396880e-07 1.380319e-06 13 38360711 38363619 2909 + 3.128 2.690 -1.457