ENSG00000120662

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239852 ENSG00000120662 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRF1 protein_coding nonsense_mediated_decay 5.399648 2.157523 7.556826 0.3350611 0.3389508 1.803641 0.4003923 0.07751219 0.5543622 0.02680596 0.10590549 2.68906558 0.08155417 0.03616667 0.07370000 0.037533333 0.49888068 0.01159449 TRUE TRUE
ENST00000379480 ENSG00000120662 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRF1 protein_coding protein_coding 5.399648 2.157523 7.556826 0.3350611 0.3389508 1.803641 0.3582147 0.15548944 0.5285189 0.05881325 0.08056681 1.70225771 0.07697917 0.07233333 0.07010000 -0.002233333 0.95158497 0.01159449 FALSE TRUE
ENST00000452359 ENSG00000120662 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRF1 protein_coding protein_coding 5.399648 2.157523 7.556826 0.3350611 0.3389508 1.803641 0.6319851 0.05508565 0.8978200 0.05508565 0.06749867 3.80199490 0.09234583 0.02046667 0.11910000 0.098633333 0.01413354 0.01159449 FALSE FALSE
ENST00000480434 ENSG00000120662 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRF1 protein_coding protein_coding 5.399648 2.157523 7.556826 0.3350611 0.3389508 1.803641 0.9111746 0.56989122 0.9827969 0.13166998 0.17329125 0.77571632 0.16487500 0.25683333 0.12893333 -0.127900000 0.04035967 0.01159449 FALSE TRUE
ENST00000492827 ENSG00000120662 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRF1 protein_coding processed_transcript 5.399648 2.157523 7.556826 0.3350611 0.3389508 1.803641 0.4744234 0.24559287 0.6922804 0.05885384 0.11550979 1.45819964 0.10402500 0.11133333 0.09123333 -0.020100000 0.81096245 0.01159449   FALSE
ENST00000498245 ENSG00000120662 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRF1 protein_coding processed_transcript 5.399648 2.157523 7.556826 0.3350611 0.3389508 1.803641 0.5283203 0.19559796 0.8913434 0.10348777 0.08618339 2.13225093 0.08592083 0.07853333 0.11933333 0.040800000 0.70185099 0.01159449   FALSE
MSTRG.8642.4 ENSG00000120662 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRF1 protein_coding   5.399648 2.157523 7.556826 0.3350611 0.3389508 1.803641 0.5949278 0.45778529 0.4632421 0.23629375 0.23238601 0.01673198 0.10827500 0.24310000 0.06003333 -0.183066667 0.76946694 0.01159449 FALSE TRUE
MSTRG.8642.8 ENSG00000120662 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRF1 protein_coding   5.399648 2.157523 7.556826 0.3350611 0.3389508 1.803641 0.3864819 0.19573456 0.4428484 0.12169849 0.02221599 1.13824403 0.09340000 0.08793333 0.05873333 -0.029200000 0.92257525 0.01159449 TRUE TRUE
MSTRG.8642.9 ENSG00000120662 HEK293_OSMI2_2hA HEK293_TMG_2hB MTRF1 protein_coding   5.399648 2.157523 7.556826 0.3350611 0.3389508 1.803641 0.1264819 0.00000000 0.4106471 0.00000000 0.13255821 5.39453839 0.02597083 0.00000000 0.05550000 0.055500000 0.01159449 0.01159449 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120662 E001 5.2327936 0.0034132042 0.630298039 0.74548043 13 41216369 41216872 504 - 0.747 0.816 0.273
ENSG00000120662 E002 1.4695075 0.0142879453 0.769434092 0.85109465 13 41216873 41216873 1 - 0.369 0.425 0.312
ENSG00000120662 E003 3.1859328 0.0548805608 0.830689399 0.89379624 13 41216874 41216974 101 - 0.608 0.574 -0.153
ENSG00000120662 E004 3.0020489 0.0058132955 0.291702834 0.43260109 13 41216975 41217057 83 - 0.518 0.688 0.759
ENSG00000120662 E005 1.7799237 0.0133058332 0.165113031 0.28184902 13 41217058 41217059 2 - 0.332 0.576 1.273
ENSG00000120662 E006 3.1481651 0.0069312673 0.169520732 0.28756689 13 41217060 41217121 62 - 0.518 0.735 0.951
ENSG00000120662 E007 7.1870494 0.0086783982 0.549643079 0.67935119 13 41217122 41217228 107 - 0.863 0.941 0.296
ENSG00000120662 E008 0.3666179 0.0294903998 0.434850082 0.57711687 13 41220537 41220643 107 - 0.076 0.192 1.541
ENSG00000120662 E009 11.8700215 0.0077687867 0.283630908 0.42377873 13 41223256 41223354 99 - 1.039 1.155 0.419
ENSG00000120662 E010 16.2780791 0.0046668747 0.484031991 0.62205103 13 41226432 41226568 137 - 1.180 1.246 0.233
ENSG00000120662 E011 0.3686942 0.0292708623 0.435191498 0.57743592 13 41226569 41226569 1 - 0.076 0.192 1.540
ENSG00000120662 E012 3.1589646 0.0428993845 0.604654364 0.72510292 13 41227000 41227121 122 - 0.609 0.509 -0.459
ENSG00000120662 E013 2.4345952 0.0061757194 0.024434112 0.06071974 13 41227122 41227245 124 - 0.369 0.735 1.729
ENSG00000120662 E014 19.1859026 0.0039612603 0.163230503 0.27937310 13 41233890 41234007 118 - 1.227 1.344 0.412
ENSG00000120662 E015 17.6893332 0.0011970074 0.779900104 0.85851462 13 41240261 41240433 173 - 1.241 1.218 -0.082
ENSG00000120662 E016 0.3697384 0.0274424043 0.037286547 0.08601099 13 41252282 41252283 2 - 0.000 0.324 11.855
ENSG00000120662 E017 11.9052633 0.0016547835 0.005326083 0.01681945 13 41252284 41252644 361 - 0.973 1.246 0.985
ENSG00000120662 E018 13.1796985 0.0016407035 0.835122058 0.89680850 13 41252645 41252663 19 - 1.121 1.102 -0.071
ENSG00000120662 E019 17.0483278 0.0115034040 0.725011592 0.81835622 13 41252664 41252704 41 - 1.212 1.245 0.118
ENSG00000120662 E020 19.4099469 0.0010715620 0.514894026 0.64961659 13 41252705 41252752 48 - 1.255 1.310 0.191
ENSG00000120662 E021 20.6385060 0.0009596891 0.658647901 0.76769044 13 41252949 41253030 82 - 1.307 1.273 -0.121
ENSG00000120662 E022 18.7175240 0.0010363811 0.187581952 0.31070188 13 41254529 41254620 92 - 1.286 1.172 -0.404
ENSG00000120662 E023 1.3370082 0.0130345680 0.280921924 0.42077986 13 41257673 41257755 83 - 0.403 0.191 -1.464
ENSG00000120662 E024 0.8909948 0.0137138279 0.603755784 0.72446604 13 41257756 41257796 41 - 0.291 0.191 -0.786
ENSG00000120662 E025 0.0000000       13 41257797 41257797 1 -      
ENSG00000120662 E026 48.4535338 0.0025087211 0.040505192 0.09194853 13 41260493 41260915 423 - 1.685 1.569 -0.395
ENSG00000120662 E027 3.7653505 0.0274069963 0.620346304 0.73754108 13 41261333 41261432 100 - 0.666 0.578 -0.385
ENSG00000120662 E028 7.1297509 0.0024105632 0.629263889 0.74465711 13 41261433 41261690 258 - 0.852 0.914 0.238
ENSG00000120662 E029 11.8672793 0.0159662571 0.251823637 0.38811611 13 41261691 41261825 135 - 1.108 0.969 -0.508
ENSG00000120662 E030 3.0739438 0.0341228499 0.942725822 0.96803462 13 41262048 41262214 167 - 0.587 0.576 -0.053
ENSG00000120662 E031 12.5193163 0.0252894841 0.403970025 0.54773308 13 41262215 41262331 117 - 1.054 1.159 0.379
ENSG00000120662 E032 6.1111927 0.0032184386 0.219458562 0.34973768 13 41262411 41262481 71 - 0.863 0.688 -0.700
ENSG00000120662 E033 1.2910239 0.0104231039 0.966751515 0.98315587 13 41263273 41263274 2 - 0.332 0.324 -0.046
ENSG00000120662 E034 9.6398732 0.0018438417 0.010994502 0.03114906 13 41263275 41263484 210 - 1.061 0.735 -1.244
ENSG00000120662 E035 14.4661906 0.0018863005 0.600728884 0.72192413 13 41263485 41263566 82 - 1.169 1.120 -0.174
ENSG00000120662 E036 3.4072548 0.0066165106 0.006462758 0.01982646 13 41263567 41263681 115 - 0.716 0.192 -2.923
ENSG00000120662 E037 0.2214452 0.0390112715 0.159333843   13 41264411 41264442 32 - 0.000 0.192 10.886