ENSG00000120647

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000239830 ENSG00000120647 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC77 protein_coding protein_coding 14.28148 9.425759 16.17961 0.7701253 1.102557 0.778858 3.928994 1.640652 4.521313 0.3387032 0.2756932 1.456893 0.2649000 0.1746667 0.2802000 0.1055333 0.121613853 0.0001320781 FALSE TRUE
ENST00000412006 ENSG00000120647 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC77 protein_coding protein_coding 14.28148 9.425759 16.17961 0.7701253 1.102557 0.778858 6.608829 3.114547 8.365731 0.6942864 0.4225193 1.422568 0.4428708 0.3261667 0.5244333 0.1982667 0.135337956 0.0001320781 FALSE TRUE
ENST00000537286 ENSG00000120647 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC77 protein_coding processed_transcript 14.28148 9.425759 16.17961 0.7701253 1.102557 0.778858 1.543153 3.276443 0.270625 0.5371944 0.1578976 -3.549811 0.1403583 0.3429000 0.0162000 -0.3267000 0.000246053 0.0001320781   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120647 E001 0.0000000       12 389273 389347 75 +      
ENSG00000120647 E002 0.0000000       12 389348 389349 2 +      
ENSG00000120647 E003 0.2998086 0.0291137588 6.036153e-01   12 389350 389361 12 + 0.089 0.166 1.040
ENSG00000120647 E004 3.6473549 0.0085291019 7.185848e-02 1.464367e-01 12 389362 389394 33 + 0.514 0.789 1.185
ENSG00000120647 E005 4.0859934 0.0052797362 8.808410e-02 1.722130e-01 12 389395 389418 24 + 0.571 0.820 1.045
ENSG00000120647 E006 6.5187304 0.0178221104 5.448272e-01 6.752447e-01 12 389419 389461 43 + 0.824 0.905 0.313
ENSG00000120647 E007 6.1268553 0.1900616445 4.729353e-01 6.119562e-01 12 389462 389486 25 + 0.807 0.885 0.301
ENSG00000120647 E008 1.5363299 0.0979302806 9.112121e-01 9.476115e-01 12 389487 389527 41 + 0.412 0.380 -0.181
ENSG00000120647 E009 0.8877700 0.0168540882 1.806960e-03 6.621338e-03 12 389972 390125 154 + 0.000 0.523 12.728
ENSG00000120647 E010 0.6256415 0.0175598919 7.437252e-01 8.322926e-01 12 395124 395221 98 + 0.225 0.166 -0.542
ENSG00000120647 E011 6.6040312 0.0982275019 3.317961e-01 4.754317e-01 12 401637 401643 7 + 0.928 0.776 -0.586
ENSG00000120647 E012 7.4971023 0.1217213416 2.691591e-01 4.076376e-01 12 401644 401650 7 + 0.983 0.805 -0.678
ENSG00000120647 E013 11.9211839 0.0210973166 9.315254e-03 2.706958e-02 12 401651 401661 11 + 1.197 0.874 -1.185
ENSG00000120647 E014 25.6700715 0.0198488477 6.300598e-03 1.940261e-02 12 401662 401684 23 + 1.497 1.234 -0.914
ENSG00000120647 E015 36.3132000 0.0120066061 2.518079e-03 8.817466e-03 12 405511 405564 54 + 1.633 1.393 -0.825
ENSG00000120647 E016 15.6907315 0.0011245646 5.441366e-02 1.169773e-01 12 409368 409421 54 + 1.261 1.087 -0.620
ENSG00000120647 E017 0.0000000       12 409422 409781 360 +      
ENSG00000120647 E018 100.1928750 0.0005193628 1.901088e-04 9.216988e-04 12 411747 411978 232 + 2.036 1.900 -0.457
ENSG00000120647 E019 79.2321088 0.0004080431 1.098443e-03 4.298633e-03 12 418494 418636 143 + 1.933 1.800 -0.449
ENSG00000120647 E020 0.7718584 0.0155017031 7.404229e-01 8.298491e-01 12 418637 418881 245 + 0.225 0.286 0.457
ENSG00000120647 E021 65.6072501 0.0019766932 1.385131e-02 3.789013e-02 12 428769 428865 97 + 1.847 1.727 -0.405
ENSG00000120647 E022 61.7947683 0.0051026832 9.706977e-02 1.859994e-01 12 430664 430736 73 + 1.811 1.718 -0.315
ENSG00000120647 E023 70.8988697 0.0016005606 3.245830e-02 7.673173e-02 12 431866 431954 89 + 1.872 1.774 -0.328
ENSG00000120647 E024 48.9560298 0.0007724219 1.303443e-01 2.346360e-01 12 433174 433210 37 + 1.706 1.629 -0.262
ENSG00000120647 E025 70.9865854 0.0006910685 2.211597e-01 3.518154e-01 12 433211 433322 112 + 1.857 1.807 -0.169
ENSG00000120647 E026 2.4983858 0.0175093361 9.577212e-01 9.774932e-01 12 433407 433480 74 + 0.514 0.524 0.049
ENSG00000120647 E027 69.3516117 0.0006534711 7.909259e-01 8.662903e-01 12 438335 438460 126 + 1.824 1.840 0.053
ENSG00000120647 E028 55.6078047 0.0005406884 1.798682e-01 3.010123e-01 12 438461 438554 94 + 1.712 1.780 0.231
ENSG00000120647 E029 1.1876829 0.0108817556 1.871714e-01 3.101845e-01 12 438555 438611 57 + 0.413 0.166 -1.766
ENSG00000120647 E030 77.4743071 0.0003939221 8.658214e-02 1.699359e-01 12 440617 440742 126 + 1.852 1.925 0.247
ENSG00000120647 E031 83.3490745 0.0035460692 2.562705e-01 3.932292e-01 12 440844 440996 153 + 1.886 1.945 0.197
ENSG00000120647 E032 258.7576471 0.0009510763 2.537816e-20 1.681642e-18 12 441774 442642 869 + 2.308 2.523 0.716