ENSG00000120616

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319778 ENSG00000120616 HEK293_OSMI2_2hA HEK293_TMG_2hB EPC1 protein_coding protein_coding 6.663098 3.652295 9.921729 0.432232 0.3832066 1.439297 3.6579027 2.43645341 5.8885977 0.18318615 0.20412221 1.2696802 0.56666250 0.67390000 0.59373333 -0.08016667 3.175306e-01 4.939122e-07 FALSE TRUE
ENST00000375110 ENSG00000120616 HEK293_OSMI2_2hA HEK293_TMG_2hB EPC1 protein_coding protein_coding 6.663098 3.652295 9.921729 0.432232 0.3832066 1.439297 0.8012817 0.00000000 1.0253821 0.00000000 0.14835695 6.6940195 0.10110417 0.00000000 0.10473333 0.10473333 4.939122e-07 4.939122e-07 FALSE TRUE
ENST00000469059 ENSG00000120616 HEK293_OSMI2_2hA HEK293_TMG_2hB EPC1 protein_coding protein_coding 6.663098 3.652295 9.921729 0.432232 0.3832066 1.439297 0.3353448 0.21831914 0.3150707 0.11042019 0.04809025 0.5097018 0.05801250 0.05476667 0.03146667 -0.02330000 5.973337e-01 4.939122e-07 TRUE FALSE
ENST00000479380 ENSG00000120616 HEK293_OSMI2_2hA HEK293_TMG_2hB EPC1 protein_coding retained_intron 6.663098 3.652295 9.921729 0.432232 0.3832066 1.439297 0.3144249 0.04813933 0.6603356 0.02598613 0.22775355 3.5272971 0.03764583 0.01246667 0.06506667 0.05260000 7.138107e-02 4.939122e-07 TRUE TRUE
ENST00000480402 ENSG00000120616 HEK293_OSMI2_2hA HEK293_TMG_2hB EPC1 protein_coding protein_coding 6.663098 3.652295 9.921729 0.432232 0.3832066 1.439297 0.3903633 0.59862815 0.3840140 0.05000344 0.09860010 -0.6273142 0.08580000 0.17006667 0.03946667 -0.13060000 1.616563e-03 4.939122e-07 TRUE FALSE
ENST00000492710 ENSG00000120616 HEK293_OSMI2_2hA HEK293_TMG_2hB EPC1 protein_coding retained_intron 6.663098 3.652295 9.921729 0.432232 0.3832066 1.439297 0.4570205 0.20144157 0.5701587 0.20144157 0.44561976 1.4561886 0.05941667 0.04536667 0.05436667 0.00900000 8.606219e-01 4.939122e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120616 E001 105.3246779 0.0007456278 2.837604e-11 5.488825e-10 10 32267751 32268480 730 - 1.915 2.144 0.769
ENSG00000120616 E002 74.2796316 0.0003673801 3.654517e-04 1.640493e-03 10 32268481 32268930 450 - 1.797 1.941 0.486
ENSG00000120616 E003 61.0905247 0.0005700497 8.335988e-02 1.648274e-01 10 32268931 32269135 205 - 1.742 1.820 0.263
ENSG00000120616 E004 60.7128677 0.0004745925 2.040721e-02 5.234625e-02 10 32271554 32271713 160 - 1.729 1.834 0.353
ENSG00000120616 E005 65.0030643 0.0044138795 1.661203e-01 2.831627e-01 10 32271714 32271917 204 - 1.767 1.836 0.234
ENSG00000120616 E006 45.1646343 0.0033532080 2.784456e-01 4.181253e-01 10 32272026 32272167 142 - 1.613 1.673 0.202
ENSG00000120616 E007 0.4449813 0.0213648388 8.132478e-01 8.815889e-01 10 32272168 32272249 82 - 0.146 0.184 0.402
ENSG00000120616 E008 5.9256243 0.0156937081 6.515316e-01 7.623839e-01 10 32273014 32273082 69 - 0.833 0.761 -0.284
ENSG00000120616 E009 3.9402888 0.0454413814 2.056937e-01 3.332853e-01 10 32273083 32273162 80 - 0.733 0.493 -1.064
ENSG00000120616 E010 41.5803560 0.0005959381 9.313342e-02 1.800227e-01 10 32273163 32273281 119 - 1.627 1.522 -0.358
ENSG00000120616 E011 3.7077263 0.0561744446 8.670187e-01 9.184251e-01 10 32273922 32274038 117 - 0.662 0.620 -0.179
ENSG00000120616 E012 2.3721290 0.0073468504 9.608737e-01 9.793601e-01 10 32281859 32284697 2839 - 0.505 0.494 -0.055
ENSG00000120616 E013 76.3698998 0.0004226991 3.544762e-04 1.597356e-03 10 32284698 32285050 353 - 1.902 1.736 -0.560
ENSG00000120616 E014 3.1932957 0.0053186743 4.566237e-02 1.014138e-01 10 32285051 32286693 1643 - 0.681 0.314 -1.844
ENSG00000120616 E015 51.4441767 0.0104616933 5.198241e-02 1.126972e-01 10 32286694 32286842 149 - 1.729 1.576 -0.519
ENSG00000120616 E016 1.6629549 0.0082713770 1.374346e-01 2.445071e-01 10 32286843 32286925 83 - 0.477 0.185 -1.918
ENSG00000120616 E017 35.8094266 0.0006060527 6.907902e-01 7.923814e-01 10 32286926 32287015 90 - 1.544 1.515 -0.098
ENSG00000120616 E018 52.9474041 0.0023197410 4.278799e-02 9.616181e-02 10 32287098 32287274 177 - 1.736 1.615 -0.410
ENSG00000120616 E019 49.1470778 0.0013831270 2.908612e-04 1.342693e-03 10 32291163 32291322 160 - 1.728 1.508 -0.747
ENSG00000120616 E020 0.7469680 0.0171176120 1.577993e-01 2.721947e-01 10 32291323 32292495 1173 - 0.301 0.000 -10.136
ENSG00000120616 E021 43.8191473 0.0005704694 1.035304e-02 2.963394e-02 10 32292496 32292644 149 - 1.665 1.508 -0.534
ENSG00000120616 E022 41.4192879 0.0100646664 7.545220e-02 1.522440e-01 10 32292988 32293194 207 - 1.635 1.488 -0.503
ENSG00000120616 E023 32.4010113 0.0068999704 2.793215e-02 6.788011e-02 10 32293592 32293737 146 - 1.539 1.357 -0.627
ENSG00000120616 E024 36.8128485 0.0041816743 7.508349e-06 5.131066e-05 10 32305772 32305931 160 - 1.632 1.289 -1.179
ENSG00000120616 E025 12.9623735 0.0013574882 7.190799e-10 1.096752e-08 10 32345112 32345562 451 - 0.857 1.422 2.034
ENSG00000120616 E026 4.2542874 0.0124994364 7.016326e-02 1.436360e-01 10 32345563 32345623 61 - 0.602 0.865 1.078
ENSG00000120616 E027 45.0850990 0.0018481451 1.433026e-01 2.525112e-01 10 32346763 32347218 456 - 1.611 1.691 0.273
ENSG00000120616 E028 0.0000000       10 32377113 32377435 323 -      
ENSG00000120616 E029 3.9944021 0.0040670828 1.257251e-03 4.834129e-03 10 32378491 32378798 308 - 0.792 0.184 -3.297