ENSG00000120594

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377238 ENSG00000120594 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXDC2 protein_coding processed_transcript 1.507853 0.8632987 2.497962 0.03061274 0.06854254 1.521968 0.02716001 0.00000000 0.1699570 0.00000000 0.1699570 4.169580 0.01454583 0.000000000 0.07126667 0.07126667 1.00000000 0.00494699 FALSE TRUE
ENST00000377242 ENSG00000120594 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXDC2 protein_coding protein_coding 1.507853 0.8632987 2.497962 0.03061274 0.06854254 1.521968 0.64198964 0.39689922 0.8890546 0.02831326 0.2377948 1.143737 0.42795417 0.459633333 0.35216667 -0.10746667 0.67326125 0.00494699 FALSE TRUE
ENST00000377252 ENSG00000120594 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXDC2 protein_coding protein_coding 1.507853 0.8632987 2.497962 0.03061274 0.06854254 1.521968 0.15657993 0.00580463 0.4950629 0.00580463 0.1084528 4.998044 0.08440417 0.007066667 0.20060000 0.19353333 0.00494699 0.00494699 FALSE TRUE
MSTRG.3621.4 ENSG00000120594 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXDC2 protein_coding   1.507853 0.8632987 2.497962 0.03061274 0.06854254 1.521968 0.66132723 0.46059481 0.9438875 0.03364780 0.1127175 1.019334 0.46472083 0.533333333 0.37593333 -0.15740000 0.26453517 0.00494699 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120594 E001 0.4804688 0.0222853135 9.467153e-01 9.705478e-01 10 19815846 19815894 49 + 0.157 0.172 0.154
ENSG00000120594 E002 6.6593074 0.0047637109 1.761183e-01 2.961704e-01 10 19816239 19816431 193 + 0.795 0.967 0.658
ENSG00000120594 E003 4.7489873 0.0117480902 5.452626e-01 6.756429e-01 10 19816432 19816433 2 + 0.711 0.802 0.366
ENSG00000120594 E004 12.1355578 0.0180727499 4.580422e-01 5.983596e-01 10 19816434 19816565 132 + 1.067 1.151 0.300
ENSG00000120594 E005 33.2805918 0.0136900250 7.586444e-01 8.431919e-01 10 19816566 19817191 626 + 1.527 1.504 -0.080
ENSG00000120594 E006 20.6062847 0.0010322458 7.645629e-01 8.476069e-01 10 20001775 20001986 212 + 1.328 1.310 -0.063
ENSG00000120594 E007 0.0000000       10 20043320 20043418 99 +      
ENSG00000120594 E008 20.9972216 0.0008613571 1.507719e-01 2.627306e-01 10 20046869 20047015 147 + 1.281 1.394 0.394
ENSG00000120594 E009 16.2254809 0.0187443973 5.939270e-01 7.162352e-01 10 20068170 20068239 70 + 1.188 1.247 0.210
ENSG00000120594 E010 21.5441068 0.0158713355 1.820526e-01 3.037850e-01 10 20143295 20143417 123 + 1.276 1.407 0.454
ENSG00000120594 E011 19.8970401 0.0200585036 1.217446e-01 2.224189e-01 10 20147784 20147902 119 + 1.240 1.400 0.560
ENSG00000120594 E012 20.6223480 0.0352711957 4.594738e-02 1.019381e-01 10 20164468 20164567 100 + 1.223 1.462 0.830
ENSG00000120594 E013 17.5404772 0.0038833193 3.827461e-02 8.786334e-02 10 20176999 20177094 96 + 1.187 1.367 0.630
ENSG00000120594 E014 17.7202705 0.0017417693 2.623934e-01 4.001806e-01 10 20177328 20177409 82 + 1.223 1.320 0.341
ENSG00000120594 E015 18.0985032 0.0010429552 3.815826e-01 5.258846e-01 10 20211669 20211729 61 + 1.234 1.310 0.267
ENSG00000120594 E016 27.5888409 0.0009214312 4.186819e-01 5.619176e-01 10 20217426 20217576 151 + 1.413 1.472 0.205
ENSG00000120594 E017 15.3038286 0.0014184085 1.478198e-01 2.587185e-01 10 20219064 20219102 39 + 1.135 1.267 0.467
ENSG00000120594 E018 23.3440985 0.0009006728 3.928488e-03 1.294218e-02 10 20245345 20245505 161 + 1.276 1.486 0.728
ENSG00000120594 E019 31.0112056 0.0006510892 1.445148e-05 9.249916e-05 10 20279703 20279984 282 + 1.370 1.641 0.927
ENSG00000120594 E020 84.1802522 0.0013190093 3.724238e-11 7.058986e-10 10 20279985 20284183 4199 + 1.993 1.711 -0.948
ENSG00000120594 E021 109.0227829 0.0003922937 1.599531e-08 1.898424e-07 10 20284184 20289856 5673 + 2.080 1.890 -0.635