ENSG00000120549

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376451 ENSG00000120549 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1217 protein_coding protein_coding 0.3004086 0.3322904 0.2303853 0.007071846 0.05909261 -0.5098718 0.03832536 0.12386877 0.00000000 0.03614095 0.000000000 -3.7427475 0.11838750 0.3685000 0.00000000 -0.368500000 0.01906268 0.01906268 FALSE TRUE
ENST00000376452 ENSG00000120549 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1217 protein_coding protein_coding 0.3004086 0.3322904 0.2303853 0.007071846 0.05909261 -0.5098718 0.01362145 0.00000000 0.02132776 0.00000000 0.021327758 1.6474415 0.03072917 0.0000000 0.06193333 0.061933333 0.63053613 0.01906268 FALSE TRUE
ENST00000376454 ENSG00000120549 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1217 protein_coding protein_coding 0.3004086 0.3322904 0.2303853 0.007071846 0.05909261 -0.5098718 0.04305204 0.04365498 0.02915433 0.04365498 0.021666750 -0.4545400 0.17240417 0.1362667 0.15526667 0.019000000 0.88603209 0.01906268 FALSE TRUE
ENST00000396445 ENSG00000120549 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1217 protein_coding protein_coding 0.3004086 0.3322904 0.2303853 0.007071846 0.05909261 -0.5098718 0.02337952 0.00000000 0.02078892 0.00000000 0.010659683 1.6224115 0.07336250 0.0000000 0.12540000 0.125400000 0.46884258 0.01906268 FALSE TRUE
ENST00000396446 ENSG00000120549 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1217 protein_coding protein_coding 0.3004086 0.3322904 0.2303853 0.007071846 0.05909261 -0.5098718 0.01076134 0.00000000 0.00000000 0.00000000 0.000000000 0.0000000 0.05050833 0.0000000 0.00000000 0.000000000   0.01906268 FALSE TRUE
ENST00000458595 ENSG00000120549 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1217 protein_coding protein_coding 0.3004086 0.3322904 0.2303853 0.007071846 0.05909261 -0.5098718 0.05951410 0.15758400 0.09294093 0.03189087 0.005873872 -0.7030676 0.20941667 0.4728000 0.46523333 -0.007566667 1.00000000 0.01906268 FALSE TRUE
ENST00000635163 ENSG00000120549 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA1217 protein_coding protein_coding 0.3004086 0.3322904 0.2303853 0.007071846 0.05909261 -0.5098718 0.02714949 0.00000000 0.05685617 0.00000000 0.056856167 2.7410606 0.07086667 0.0000000 0.16510000 0.165100000 0.71245477 0.01906268 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000120549 E001 0.0000000       10 23694746 23694781 36 +      
ENSG00000120549 E002 0.1482932 0.042787634 1.000000000   10 23694782 23695234 453 + 0.000 0.084 8.714
ENSG00000120549 E003 0.0000000       10 23877406 23877495 90 +      
ENSG00000120549 E004 0.0000000       10 24007225 24007374 150 +      
ENSG00000120549 E005 0.0000000       10 24042131 24042495 365 +      
ENSG00000120549 E006 0.1472490 0.043202391 0.209178155   10 24208791 24209137 347 + 0.174 0.000 -13.245
ENSG00000120549 E007 0.3299976 0.028247126 0.544182522   10 24209138 24209166 29 + 0.000 0.155 11.804
ENSG00000120549 E008 0.8469850 0.014797742 0.612141741 0.73114142 10 24209167 24209263 97 + 0.174 0.269 0.804
ENSG00000120549 E009 2.4711269 0.006662494 0.418421148 0.56168296 10 24219626 24219909 284 + 0.597 0.468 -0.611
ENSG00000120549 E010 0.0000000       10 24239195 24239337 143 +      
ENSG00000120549 E011 0.0000000       10 24254123 24255245 1123 +      
ENSG00000120549 E012 0.0000000       10 24255246 24255333 88 +      
ENSG00000120549 E013 0.0000000       10 24255334 24255596 263 +      
ENSG00000120549 E014 0.0000000       10 24367119 24367168 50 +      
ENSG00000120549 E015 1.8769220 0.008349476 0.288565420 0.42916129 10 24380869 24381005 137 + 0.539 0.360 -0.931
ENSG00000120549 E016 0.9620705 0.013696863 0.007270911 0.02192871 10 24381006 24381067 62 + 0.539 0.085 -3.516
ENSG00000120549 E017 0.8104533 0.015086921 0.644304990 0.75663779 10 24432995 24433193 199 + 0.298 0.216 -0.611
ENSG00000120549 E018 0.9179615 0.014903070 0.315665183 0.45843067 10 24438386 24438479 94 + 0.394 0.216 -1.197
ENSG00000120549 E019 0.0000000       10 24449433 24449764 332 +      
ENSG00000120549 E020 0.0000000       10 24466531 24466790 260 +      
ENSG00000120549 E021 5.8217184 0.003615519 0.592443430 0.71499229 10 24473228 24474060 833 + 0.839 0.774 -0.257
ENSG00000120549 E022 0.0000000       10 24494500 24494604 105 +      
ENSG00000120549 E023 0.0000000       10 24494974 24495146 173 +      
ENSG00000120549 E024 1.5522073 0.023364531 0.748165390 0.83548597 10 24495147 24495196 50 + 0.298 0.362 0.400
ENSG00000120549 E025 3.2483423 0.203781934 0.733647810 0.82482153 10 24501379 24501545 167 + 0.597 0.567 -0.133
ENSG00000120549 E026 2.3217739 0.021675740 0.570087073 0.69659862 10 24513259 24513347 89 + 0.394 0.499 0.546
ENSG00000120549 E027 1.6950141 0.009237208 0.125555732 0.22793937 10 24513348 24513434 87 + 0.174 0.467 1.973
ENSG00000120549 E028 1.9864037 0.026097298 0.295322924 0.43645985 10 24520123 24520253 131 + 0.298 0.497 1.121
ENSG00000120549 E029 2.4261867 0.006757049 0.458567938 0.59887717 10 24521782 24521929 148 + 0.394 0.527 0.680
ENSG00000120549 E030 5.6711439 0.003177064 0.107190259 0.20137916 10 24524323 24524764 442 + 0.597 0.833 0.974
ENSG00000120549 E031 2.2089933 0.007243862 0.064318691 0.13389650 10 24527936 24527942 7 + 0.174 0.527 2.266
ENSG00000120549 E032 3.7505305 0.005623304 0.086370968 0.16959702 10 24527943 24528119 177 + 0.394 0.688 1.391
ENSG00000120549 E033 0.4448795 0.546144864 0.567496788 0.69427947 10 24531830 24531832 3 + 0.000 0.206 11.978
ENSG00000120549 E034 2.9388216 0.045261840 0.788186249 0.86434769 10 24531833 24531993 161 + 0.597 0.552 -0.203
ENSG00000120549 E035 3.1562144 0.134588518 0.758860981 0.84334852 10 24533070 24533211 142 + 0.597 0.561 -0.164
ENSG00000120549 E036 1.8683997 0.061043908 0.144760750 0.25449837 10 24533212 24533237 26 + 0.174 0.471 1.992
ENSG00000120549 E037 2.6079677 0.007251885 0.182822066 0.30473294 10 24536774 24536893 120 + 0.648 0.435 -0.999
ENSG00000120549 E038 0.0000000       10 24542420 24542506 87 +      
ENSG00000120549 E039 0.0000000       10 24542507 24542542 36 +      
ENSG00000120549 E040 0.0000000       10 24542543 24542692 150 +      
ENSG00000120549 E041 0.8010032 0.079485963 0.197218887 0.32274737 10 24542693 24542770 78 + 0.394 0.156 -1.776
ENSG00000120549 E042 4.9231369 0.009269661 0.714506161 0.81069083 10 24542883 24543708 826 + 0.773 0.724 -0.197
ENSG00000120549 E043 1.1092177 0.012385439 0.142061192 0.25084881 10 24543709 24543980 272 + 0.473 0.216 -1.611
ENSG00000120549 E044 1.4339167 0.013906651 0.840295647 0.90028755 10 24543981 24544481 501 + 0.394 0.359 -0.198
ENSG00000120549 E045 3.4538213 0.004884574 0.217735050 0.34766661 10 24544981 24545103 123 + 0.735 0.554 -0.780
ENSG00000120549 E046 0.8449086 0.014816403 0.612146224 0.73114142 10 24545104 24545268 165 + 0.174 0.269 0.804
ENSG00000120549 E047 0.3299976 0.028247126 0.544182522   10 24545269 24545316 48 + 0.000 0.155 11.804
ENSG00000120549 E048 1.3212234 0.223750734 0.439062622 0.58085150 10 24545317 24545826 510 + 0.174 0.367 1.431
ENSG00000120549 E049 14.1481468 0.001703013 0.749180705 0.83620082 10 24545827 24547843 2017 + 1.140 1.116 -0.087
ENSG00000120549 E050 0.0000000       10 24547844 24547848 5 +